Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker [0.03%]
非病毒性肝细胞癌的miRNA谱分析确定miR-1972为潜在的良好预后标志物
Venkata Ramana Mallela,Marie Rajtmajerová,Esraa Ali et al.
Venkata Ramana Mallela et al.
Background & aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-cat...
Progenitor cells, microglia, and non-coding RNAs: Orchestrators of glioblastoma pathogenesis and therapeutic resistance [0.03%]
前体细胞、小胶质细胞和非编码RNA：胶质母细胞瘤发病机制及治疗耐药性的调控者
Adil Husain,Firoz Ahmad,Sandeep Pandey et al.
Adil Husain et al.
Glioblastoma (GB) remains a major challenge owing to its extremely aggressive nature and resistance to conventional therapies. This review focuses on the intricate roles of progenitor cells, microglia, and non-coding RNAs (ncRNAs) in orches...
LncRNA MYO16-AS1 and MICAL2 axis sustains proliferation and migration in ovarian cancer cells and unveils a therapeutic vulnerability in patient-derived tumor organoids [0.03%]
长链非编码RNA MYO16-AS1和MICAL2轴维持卵巢癌细胞的增殖和迁移，并在患者来源肿瘤类器官中揭示了治疗弱点
Mohammad Ahmad,Lucie Thorel,Emilie Brotin et al.
Mohammad Ahmad et al.
Ovarian carcinoma (OC) exhibits a 5-year survival rate of below 40 %, mainly due to late-stage diagnosis and recurrence associated to resistance to chemotherapy. Long noncoding RNAs (lncRNAs) are involved in numerous cellular processes of c...
Emerging roles of tsRNAs in programmed cell death and disease therapeutics: challenges, opportunities, and future directions [0.03%]
tsRNA在程序性细胞死亡及疾病治疗中的新兴作用：挑战、机遇和未来方向
Zhe Li,Bo Zhang,Yanru Pan et al.
Zhe Li et al.
Programmed cell death (PCD), which includes various forms such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, plays a pivotal role in disease pathogenesis and progression. tRNA-derived small RNAs (tsRNAs) have emerged as...
The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis [0.03%]
血浆外泌体miR-15a-5p靶向CF修饰蛋白IGF1R调控肺泡上皮细胞自噬影响肺间质纤维化的机制研究
Yina Li,Nan Wang,Jinying Hu et al.
Yina Li et al.
Aims: This study investigates how plasma exosomal miRNAs regulate core fucosylation (CF)-modified targets to influence autophagy and fibrosis in idiopathic pulmonary fibrosis (IPF), aiming to identify novel therapeutic st...
Xia Cai,Hui Shan,Jiaojiao Wang et al.
Xia Cai et al.
Small RNAs (sRNAs) are widely used by bacteria to regulate diverse biological processes. Although they are generally considered "non-coding", some sRNAs (called dual-function sRNAs) have been found to encode small proteins, which are usuall...
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging [0.03%]
5' tiRNA-Glu-TTC靶向TRPV3并激活PI3K/AKT信号通路以调节皮肤光老化
Zhuohong Xu,Lihao Liu,Xiaoxi Dai et al.
Zhuohong Xu et al.
tRNA-derived small RNAs (tsRNAs), a class of non-coding RNAs (ncRNAs), have garnered increasing research interest for their potential roles in various biological processes. Among these, 5'tiRNA-Glu-TTC has been implicated in aging, but its ...
Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 [0.03%]
长非编码RNA LINC00339通过结合PARP1调节CDC42促进骨质疏松的发展
Dong-Li Zhu,Yan Zhang,Xiao-Yu Zhang et al.
Dong-Li Zhu et al.
Background: Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Our previous investigation provided preliminary evidence that single nucleot...
LncRNA MIR155HG suppresses cell apoptosis by activating autophagy via miR-7036b-3p/GPNMB axis and AMPK/mTOR signaling in spinal cord injury [0.03%]
长链非编码RNA MIR155HG通过miR-7036b-3p/GPNMB轴和AMPK/mTOR信号抑制脊髓损伤中的细胞凋亡
Ruoxi Liu,Jintao Ye,Sihua Huang
Ruoxi Liu
Background: Long non-coding RNAs (lncRNAs) participate in spinal cord injury (SCI) development through regulating autophagy and neuronal apoptosis. Previously, MIR155HG was identified as an upregulated lncRNA in rat bladd...
Dual role of lncRNA OTUD6B-AS1 in immune evasion and ferroptosis resistance: A prognostic and therapeutic biomarker in breast cancer [0.03%]
长链非编码RNA OTUD6B-AS1在免疫逃逸和铁死亡抵抗中的双重作用：乳腺癌预后和治疗生物标志物
Jia-Ning Zhang,Zi-Lu Yi,Xi-Rui Zhou et al.
Jia-Ning Zhang et al.
Background: Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in tumorigenesis and therapeutic resistance. This study investigates the prognostic significance and dual biological functions of lncRNA OTUD6B...