Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease [0.03%]
Jekyll或Hyde：miR-145-5p在人类健康和疾病中的多面作用
Md Sohanur Rahman,Suvankar Ghorai,Kingshuk Panda et al.
Md Sohanur Rahman et al.
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate gene expression by recognizing com...
Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances [0.03%]
非编码RNA在脂肪肉瘤发生发展中的作用及转化治疗前景挑战与机遇并存
Zhi Xiong Chong,Wan Yong Ho,Swee Keong Yeap
Zhi Xiong Chong
Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) can bind various cel...
Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications [0.03%]
非编码RNA与肺癌中PI3K信号通路的调控：最新研究进展及潜在临床应用
Mehrdad Hashemi,Asal Abolghasemi Fard,Bita Pakshad et al.
Mehrdad Hashemi et al.
Lung cancer (LC) is one of the most common causes of cancer-related death worldwide. It has been demonstrated that the prognosis of current drug treatments is affected by a variety of factors, including late stage, tumor recurrence, inacces...
LncRNA RNF144A-AS1 gene polymorphisms and their influence on lung cancer patients in the Chinese Han population [0.03%]
长链非编码RNA基因RNF144A-AS1多态性及其对中国汉族人群肺癌患者的影响研究
Hongjiao Wu,Yuning Xie,Ang Li et al.
Hongjiao Wu et al.
Lung cancer is primarily classified as NSCLC, which is distinguished by a wide range of genetic variations. This study focused on RNF144A-AS1, a relatively unexplored lncRNA, to explore the impact of its genetic polymorphisms on the suscept...
Glycolysis regulated exosomal LINC01214 inhibited CD8+ T cell function and induced anti-PD1 resistance in melanoma via modulating miR-4492/PPP1R11 axis [0.03%]
糖酵解调控的外泌体LINC01214通过调节miR-4492 / PPP1R11轴抑制CD8+T细胞功能并诱导黑色素瘤中的抗PD1耐药性
Zhi Ding,Baojin Wu,Junyi Yang et al.
Zhi Ding et al.
Background: Long non-coding RNAs (lncRNAs) can be incorporated into exosomes to mediate the intercellular communication, regulating the occurrence, development, and immunosuppression of cancers. T cell dysfunction has bee...
Emerging role of endogenous peptides encoded by non-coding RNAs in cancer biology [0.03%]
由非编码RNA编码的内源性肽在癌症生物学中的作用不容忽视
Anna Lucia Tornesello,Andrea Cerasuolo,Noemy Starita et al.
Anna Lucia Tornesello et al.
Non-coding RNAs have long been recognized for their regulatory roles in various cellular processes, including cancer development and progression. Recent advancements have shed light on a novel aspect of non-coding RNA biology, revealing the...
tsRNA in head and neck tumors: Opportunities and challenges in the field [0.03%]
头颈部肿瘤中的tsRNA：领域内的机遇与挑战
Zhuo Wu,Yufeng Xu,Changzeng Zhou et al.
Zhuo Wu et al.
Transfer RNA-derived small RNAs (tsRNAs) are a newly recognized class of small non-coding RNAs that are implicated in a variety of cancers, including head and neck tumors. Studies have identified tsRNAs with differential expression profiles...
Study on molecular mechanism of intervertebral disc degeneration by single cell hdWGCNA combined with transcriptome sequencing [0.03%]
单细胞HDWGCNA联合转录组测序研究椎间盘退变的分子机制
Xuan Zhao,Qijun Wang,Wei Wang et al.
Xuan Zhao et al.
Background: Intervertebral disc degeneration (IVDD) is one of the important causes of lower back pain, seriously affecting people's health and quality of life. This research employs single-cell analysis to identify the sp...
Molecular insight of miRNA-217 role in the pathogenesis of myocardial infarction: Promising diagnostic biomarker and therapeutic target [0.03%]
miRNA-217在心肌梗死发病机制中的分子作用机制：极具潜力的诊断生物标志物和治疗靶点
Mai A Zaafan,Amr M Abdelhamid
Mai A Zaafan
Background: Globally, myocardial infarction (MI) is one of the main causes of death. This study aims to investigate the role of miR-217 in the pathogenesis through targeting MAPK and PI3K/AKT signaling pathways in experim...
Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis [0.03%]
机械敏感长链非编码RNA H19通过靶向miR-148a促进创伤性关节炎软骨细胞自噬，但不是细胞焦亡
Xuchang Zhou,Hong Cao,Tao Liao et al.
Xuchang Zhou et al.
Objective: Investigating whether mechanosensitive lncRNA H19 can directly target miR-148a to alleviate cartilage damage in post-traumatic osteoarthritis (PTOA). ...