Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells [0.03%]
人正常和癌细胞中小核仁RNA滞留转录本的特征分析
Guglielmo Rambaldelli,Sidra Asghar,Giulia Venturi et al.
Guglielmo Rambaldelli et al.
Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained introns of specific mRNA isoforms expr...
Uremic toxins levels are associated with miR-223 in chronic kidney disease-associated anemia [0.03%]
慢性肾脏病相关性贫血患者尿毒症毒素水平与miR-223的相关性研究
Emma Brisot,Pierre-Marie Leprêtre,Eya Hamza et al.
Emma Brisot et al.
Chronic kidney disease (CKD) poses a significant threat, with increased rates of cardiovascular and all-cause mortality. Anemia, common in CKD, is associated with accumulation of uremic toxins in the bloodstream. We previously demonstrated ...
CircRNA-based AntimiR therapy: A novel approach to hypertension treatment [0.03%]
基于环状circRNA的抗高血压疗法：一种治疗高血压的新方法
Vahideh Tarhriz,Kamran Hosseini,Leila Abkhooie et al.
Vahideh Tarhriz et al.
The increasing recognition of the types and functions of non-coding RNAs has opened new avenues for their use as novel therapeutic strategies in the treatment of chronic diseases such as hypertension. While most preclinical and clinical stu...
Xiaoyu Ma,Jiesi Xu,Guoping Li
Xiaoyu Ma
Cell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death. The relationship be...
Circ_0054633 silencing suppresses hyperglycemia-induced extracellular matrix accumulation in renal mesangial cells by regulating MiR-136-5p/SMAD3 signaling [0.03%]
circ_0054633通过调控miR-136-5p/SMAD3信号抑制高糖诱导的肾系膜细胞外基质蓄积
Qing Jiang,Hongxin Chen,Ke Wang et al.
Qing Jiang et al.
Diabetic kidney disease (DKD) is the most common complication of diabetes mellitus (DM), with excessive deposition of the extracellular matrix (ECM) produced by glomerular mesangial cells being its critical hallmark. circ_0054633, a circula...
Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells [0.03%]
棕榈酸通过降低肝癌细胞中LDLR依赖性摄取巨噬细胞源外泌体而减少胆固醇摄取
Bootsakorn Boonkaew,Nantawat Satthawiwat,Bianca C Pachane et al.
Bootsakorn Boonkaew et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by a complicated interaction of lipotoxicity and inflammation in the liver, yet the mechanisms linking these phenomena remain incompletely understood. In this...
The role of non-coding RNA regulates stem cell programmed death in disease therapy [0.03%]
非编码RNA在调控干细胞程序性死亡的疾病治疗作用
Ziling Liao,Weidong Liu,Lei Wang et al.
Ziling Liao et al.
Programmed cell death (PCD), an essential and inevitable phenomenon, is integral to organismal development. It not only maintains cellular homeostasis but also prevents aberrant cell proliferation, thereby protecting normal growth and devel...
The mechanism by which MALAT1/CREG1 regulates premature rupture of fetal membrane through autophagy mediated differentiation of amniotic fibroblasts [0.03%]
lncRNA MALAT1/CREG1通过自噬介导的羊膜成纤维细胞分化在胎膜早破的发生发展中的机制研究
Xiaomei Huang,Ting Huang,Aixing Chen et al.
Xiaomei Huang et al.
Background: Premature rupture of fetal membrane (PROM) is one of the main causes of premature delivery. The amniotic membrane plays a major role in bearing weight, and amniotic fibroblasts play an important role. The purp...
HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis [0.03%]
HNRNPC通过阻碍Nrf2/GPX4轴介导的铁死亡来稳定mRNA N6-甲基腺苷修饰的AC145207.5以加速结直肠癌肿瘤发生发展
Dan Liu,Shanshan Lin,Yueben Hu et al.
Dan Liu et al.
Ferroptosis is an apoptosis-independent cell death pathway characterized by heightened lipid peroxidation, which shows promise for tumor suppression. Despite extensive research on long non-coding RNAs (LncRNAs) in ferroptosis, their role in...
LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p [0.03%]
LINC02679通过靶向miR-5004-3p调节TRIML2促进胃癌增殖和侵袭
Yingying Wang,Wenbo Liu,Xiaohan Zhao et al.
Yingying Wang et al.
As a key protein, Tripartite motif family-like 2 (TRIML2) is crucial to the p53-mediated apoptosis and is correlated with tumorigenesis. Emerging evidence showed that long non-coding RNAs (lncRNAs) play roles in the malignant progression of...