Establishing hemoglobin A, F, A2 reference intervals in neonatal cord blood and clinical decision values for β-thalassemia genetic testing [0.03%]
新生儿脐带血中HbA、HbF和HbA2的参考区间及β-地中海贫血基因筛查的临床决策值确定
Sha Li,Jinye Xie,Yuan Tian et al.
Sha Li et al.
Objective: Reference intervals for hemoglobin fractions in neonatal cord blood have been reported; however, there is no consensus on population-specific reference intervals (RIs) and laboratory-derived clinical decision v...
Nanoparticle albumin-bound paclitaxel (nab-Paclitaxel): Bridging pharmacology and translational medicine in breast cancer [0.03%]
纳米白蛋白结合型紫杉醇（nab-紫杉醇）：乳腺癌药理与转化医学的桥梁
Ali G Alkhathami,Abdulrahman T Ahmed,Ahmed Hussein et al.
Ali G Alkhathami et al.
Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) represents a significant advancement in breast cancer therapy by enhancing drug delivery and minimizing solvent-related toxicity. Utilizing albumin-mediated transcytosis, nab-paclitaxel...
Integrating CAR-T cells with other immunotherapies for improved efficacy in cancer patients [0.03%]
将CAR-T细胞与其它免疫疗法结合以提高癌症患者的疗效
Gagandeep Singh,Lata Kumari,Dipansh Katoch et al.
Gagandeep Singh et al.
Chimeric Antigen Receptor (CAR) T cell therapy is a novel cum innovative treatment for cancer patients, especially the ones dealing with blood cancers. However, solid tumours remain an area where this therapy is not so effective. The challe...
Lipid nanoparticle mediated delivery of Anti-CD19 CAR mRNA to umbilical blood cord NK cells for targeting CD19⁺ primary B-ALL cells [0.03%]
脂质纳米颗粒介导的抗CD19嵌合抗原受体mRNA向脐带血NK细胞递送，以靶向CD19⁺原始B-急性淋巴细胞白血病细胞
Hossein Salehi-Shadkami,Mosslim Sedghi,Shima Tavoosi et al.
Hossein Salehi-Shadkami et al.
Chimeric antigen receptor natural killer (CAR-NK) cell therapy is recognized as a promising modality for the treatment of hematologic malignancies, particularly B-cell malignancies. In this study, we developed "off-the-shelf" anti-CD19 CAR-...
David B Olawade,Yinka Julianah Adeniji,Faithful A Olatunbosun et al.
David B Olawade et al.
Anemia affects over 1.6 billion people globally, representing a significant public health challenge, particularly in low- and middle-income countries where traditional diagnostic methods face barriers including invasive procedures, skilled ...
The efficacy and safety of anti-CD38 monoclonal antibodies in transplant-ineligible newly diagnosed multiple myeloma: A systematic review and meta-analysis of randomized controlled trials [0.03%]
抗CD38单克隆抗体在不适宜移植的新诊多发性骨髓瘤患者中疗效和安全性的系统评价和 Meta 分析
Turkan Aliyeva,Haroon Alamy,Feras Ahmad Ibrahim Ahmad et al.
Turkan Aliyeva et al.
Background: Treatment of transplant-ineligible newly diagnosed multiple myeloma (TIE-NDMM) remains challenging due to age, frailty, and comorbidities. Anti-CD38 monoclonal antibodies, particularly daratumumab, have emerge...
A systematic review of published clinical studies using cell-derived extracellular vesicles: A focus on efficacy in COVID-19 and wound healing [0.03%]
细胞来源的外泌体临床研究系统性回顾：重点聚焦新冠和伤口愈合疗效
An Duong,Philippe Giguère,Risa Shorr et al.
An Duong et al.
Background: Extracellular vesicles (EVs) are nano-sized membrane-bound particles released from cells and offer promise in cell-based regenerative therapy. Preclinical research has propelled the launch of clinical trials w...
A novel complex mutation affecting two codons in the exon 10 hotspot region of the MPL gene [0.03%]
MPL基因外显子10热点区域影响两个密码子的新杂合突变体
Giovanni Iaquinta,Alessandro Laganà,Caterina Tatarelli et al.
Giovanni Iaquinta et al.
Italian expert consensus recommendations for the safe administration of high-dose methotrexate in children with cancer and for the use of glucarpidase to manage delayed methotrexate elimination and/or high-dose methotrexate-induced acute kidney injury [0.03%]
儿童高剂量甲氨蝶呤安全使用的意大利专家共识以及迟发性甲氨蝶呤蓄积和/或高剂量甲氨蝶呤引起的急性肾损伤的处理建议
Nicolò Peccatori,Gianluigi Ardissino,Simone Cesaro et al.
Nicolò Peccatori et al.
Background: High-dose methotrexate (HD-MTX) is used to treat various malignancies in adults and children. However, HD-MTX can lead to severe toxicity, which can require the use of glucarpidase, a recombinant enzyme that r...