Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia [0.03%]
治疗多发性骨髓瘤和急性髓系白血病的CAR-T细胞新靶点和新技术
Sabrina Prommersberger,Hardikkumar Jetani,Sophia Danhof et al.
Sabrina Prommersberger et al.
Armin Ghobadi
Armin Ghobadi
Non-Hodgkin Lymphoma (NHL) is the most common hematologic malignancy. More than 20,000 people in United States, more than 37,000 people in Europe and more than 199,000 people worldwide die of NHL every year. Recent advances in immunotherape...
Caroline Lonez,Alain Hendlisz,Leila Shaza et al.
Caroline Lonez et al.
Celyad recently initiated several clinical trials with the CYAD-01 product, a natural killer group 2D (NKG2D)-based chimeric antigen receptor (CAR), in both solid and hematologic tumor types. This review discusses the unique properties of C...
Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations [0.03%]
与法国医疗卫生体系和监管制度相关的自体CAR-T细胞采集和给药注意事项
Christian Chabannon,Jérôme Larghero
Christian Chabannon
Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation that prevails in the USA or in certain Asian countries. Multiple reasons explain w...
Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy [0.03%]
嵌合抗原受体CD19CAR-T细胞治疗后的细胞因子释放综合征和神经毒性的特点及其机制探究
Jordan Gauthier,Cameron J Turtle
Jordan Gauthier
T-cells engineered to express CD19-specific chimeric antigen receptors (CD19 CAR-T cells) can achieve high response rates in patients with refractory/relapsed (R/R) CD19+ hematologic malignancies. Nonetheless, the efficacy of CD19-specific ...
Assessment of EGFR mutation status in Tunisian patients with pulmonary adenocarcinoma [0.03%]
突尼斯肺腺癌患者EGFR基因状态的评估
A Arfaoui Toumi,A Blel,R Aloui et al.
A Arfaoui Toumi et al.
Background: Despite recent advances, non-small cell lung cancer carries a grim prognosis. For appropriate treatment selection, the updated guidelines recommend broad molecular profiling for all patients with pulmonary ade...
X-linked hyper-IgM syndrome associated with pulmonary manifestations: A very rare case of functional mutation in CD40L gene in Iran [0.03%]
与肺部表现相关的X连锁高IgM综合征：伊朗CD40L基因功能突变的一个非常罕见的病例
Mehdi Torabizadeh,Mohammad Nabavi,Masoud Zadkarami et al.
Mehdi Torabizadeh et al.
Hyper IgM (HIGM) syndromes are a complex of primary immunodeficiency disorders. A 4-years-old boy with recurrent fever and chills, dyspnea, sort throat for a month was admitted to emergency department. In the current case, whole exome seque...
Infusion of in vivo expanded cord blood lymphocytes: A new strategy to control residual disease? [0.03%]
体内扩增的脐血淋巴细胞输注：控制残留病的新策略？
S Lamure,J Delage,L Vincent et al.
S Lamure et al.
Sinusoidal obstruction syndrome/veno-occlusive disease complication in lymphoma patients treated with oxaliplatin-based regimen: A case series report [0.03%]
奥沙利铂治疗淋巴瘤患者后出现肝窦阻塞综合征/血管闭塞性疾病：病例系列报告
E Bernichon,E Daguenet,C Molla et al.
E Bernichon et al.
Aim: SOS/VOD is a relevant clinical syndrome that usually appears early after hematopoietic stem cell transplantation. The purpose of this article was to report a case series of SOS/VOD in non-susceptible patients and dra...
T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients [0.03%]
阿尔及利亚克罗恩病患者中AT16L1基因T300A突变体的检测
I Aida,Y Meddour,H Kadiri et al.
I Aida et al.
The T300A variant is among the most Crohn's disease (CD) associated genetic variants. The aim of our study is to bring a first insight about the contribution of the T300A variant in a cohort of Algerian CD. In a case/control design, 118 Alg...