CD28 pathway blockade to transplant tolerance: Expanding the landscape of immune regulation [0.03%]
阻断CD28途径以实现移植耐受：扩大免疫调节领域
Mohammad Afzal Khan
Mohammad Afzal Khan
The immune system maintains a delicate balance between self-tolerance and protective immunity, but in transplantation this equilibrium shifts toward alloimmune activation, making regulatory T-cell function and costimulatory control central ...
An updated meta-analysis of umbilical cord blood to treat cerebral palsy: distinguishing cord blood infusions from mesenchymal stromal cell therapy [0.03%]
有关脐带血治疗脑瘫的最新荟萃分析：脐带血输注与间充质基质细胞疗法的区别
An Duong,Risa Shorr,David S Allan
An Duong
Treatment with umbilical cord blood (UCB) for cerebral palsy (CP) remains promising but experimental and unproven. An updated meta-analysis is needed to assess the efficacy of UCB mononuclear cells (MNCs) in comparison to UCB-derived mesenc...
Unusual expression of peripheral blood Alzheimer's markers, inflammatory cytokines, and cholinergic biomarkers in chronic kidney disease patients with cognitive dysfunction: Therapeutic impact of recombinant human erythropoietin (rHuEPO) [0.03%]
慢性肾脏病患者认知功能障碍外周血阿尔茨海默病生物标志物、炎症细胞因子和胆碱能生物标志物的非典型表达：重组人促红细胞生成素(rHuEPO)的治疗作用
Vinoth Kumar Ganesan
Vinoth Kumar Ganesan
Background: Patients with chronic kidney disease (CKD) are at a significantly increased risk of developing Alzheimer's disease (AD) and cognitive dysfunction compared to the general population. While recombinant human ery...
Efficacy and safety of Venetoclax combined with Azacitidine in the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation - a single-center retrospective study [0.03%]
伏立诺他联合阿扎胞苷治疗allo-HSCT后复发急性髓系白血病的疗效及安全性研究——单中心回顾分析
Ruijun Dong,Pengyu Zhang,Bide Zhao et al.
Ruijun Dong et al.
Background: Venetoclax in combination with azacitidine (VEN-AZA) has become the standard of care for acute myeloid leukemia (AML) patients who are elderly or unfit to receive intense chemotherapy. However, the efficacy an...
Necrotic locally advanced nasal NK/T-cell lymphoma: the timely diagnostic challenge [0.03%]
坏死型晚期鼻NK/T细胞淋巴瘤的及时诊断挑战
Réda Garidi,Hassina Aftisse,Nacera Taguelmint et al.
Réda Garidi et al.
Extranodal NK/T-cell lymphoma (ENKTCL) is an aggressive and heterogeneous disease. It is a rare non-Hodgkin lymphoma observed primarily in Asian and south-American. countries. Most patients with ENKTCL present with early-stage disease. Here...
Attenuated Salmonella as a PD-1/PD-L1 SiRNA delivery system for colorectal cancer, hepatocellular carcinoma, and melanoma: A systematic review [0.03%]
attenuated salmonella递送pd-1/pd-l1 sirna治疗结直肠癌、肝细胞癌和黑色素瘤的系统评价
Omar El-Kholy,Madeline Guy,Ahmed Adham R Elsayed et al.
Omar El-Kholy et al.
Background: Melanoma, colorectal cancer (CRC), and hepatocellular cancer (HCC) overexpress the PD-1/PD-L1 pathway to evade the immune response. Immune Checkpoint Inhibitors (ICIs) suppress this mechanism but lack specific...
Haoran Zhang,Yulun Wu,Qingqing Xiao et al.
Haoran Zhang et al.
Neutrophils extracellular traps (NETs), released by neutrophils, play a core role in the occurrence and development of atherosclerosis (AS) lesions, which components damage endothelium, destabilize plaques by inducing vascular smooth muscle...
Preclinical evidence of anti-CD19 CAR-T cell in vitro and in vivo efficacy against CD19-expressing acute myeloid leukemia [0.03%]
针对急性髓系白血病小鼠模型的抗CD19嵌合抗原受体T细胞的体外及体内疗效的前期证据
Misa Eugene Norbert,Alexis Cuffel,Jérémie Martinet et al.
Misa Eugene Norbert et al.
Objective: Chimeric antigen receptor-modified T cell (CAR-T) therapy has demonstrated remarkable efficacy against refractory B-cell malignancies. This approach is more challenging in non-B-cell hematological malignancies ...
Real-world treatment and long-term outcomes after autologous stem cell transplantation in first line for myeloma in France and Algeria before the daratumumab era [0.03%]
法国和阿尔及利亚达雷木单抗时代前的一线自体干细胞移植治疗多发性骨髓瘤的现实世界治疗及长期结局
Emilie Martin,Stéphane Morisset,Mohamad Sobh et al.
Emilie Martin et al.
Introduction: Despite numerous therapeutic advances, first line standard care for eligible multiple myeloma (MM) patients still include high-dose melphalan and autologous stem cell transplantation (ASCT). ...
IL-10+ regulatory B lymphocytes are impacted by intradermal PBMCs therapy in patients with unexplained recurrent pregnancy loss (uRPL) [0.03%]
外周血单个核细胞治疗对不明原因反复流产患者体内IL-10+调节性B淋巴细胞的影响
Lida Aslanian-Kalkhoran,Mohammad Sadegh Soltani-Zangbar,Ali Aghebati-Maleki et al.
Lida Aslanian-Kalkhoran et al.
Background: Following the confirmation of studies on the improvement of pregnancy outcomes after treatment with lymphocytes, this project aimed to assess the effectiveness of this treatment method in patients with unexpla...