A fault tree analysis of early treatment failure in Acute myeloid leukemia [0.03%]
急性髓系白血病早期治疗失败的故障树分析
Mobina Shrestha,Salina Dahal,Vishal Mandal
Mobina Shrestha
Risk assessment in AML is mainly based on cytogenetic and molecular classification. Even with these systems, induction failure and early death remain common, especially in older patients. In clinical practice, patients often do poorly when ...
Nanogels as innovative drug carriers for RNA-based skin cancer therapy: mechanistic insights and RNA encapsulation [0.03%]
纳米凝胶作为基于RNA的皮肤癌治疗的创新药物载体：机制见解和RNA封装
Nehmat Ghaboura,Muhammad Afzal,Fahad A Al-Abbasi et al.
Nehmat Ghaboura et al.
This review examines the potential application of nanogels as novel drug carriers for RNA-based therapy in the treatment of skin cancer. Relevant information was obtained from reputable scientific databases, including peer-reviewed articles...
Generalized skeletal sclerosis as a potential late effect of total body irradiation after allogeneic hematopoietic stem cell transplantation: A case report [0.03%]
全身照射后异基因造血干细胞移植的远期效应——报告一例 generalized skeletal sclerosis 病例
Bakoubassé Aïssata Son,Lucie Lemeunier,Yazid Belkacemi et al.
Bakoubassé Aïssata Son et al.
High bone mineral density (BMD) is common and sometimes an incidental finding. The causes are numerous. Among them, none has previously been attributed to total body irradiation (TBI). We present the case of a 56-year-old female patient wit...
Impact of the rest period between sequential chemotherapy and conditioning regimen prior to allogeneic hematopoietic stem cell transplantation for high-risk myeloid malignancies [0.03%]
序贯化疗与清淋前的间歇期对高危髓系肿瘤异基因造血干细胞移植后结局的影响
Valentin Amenta,Anne Sonet,Elodie Collinge et al.
Valentin Amenta et al.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment for relapsed/refractory acute myeloid leukemia (r/rAML), high-risk myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN). S...
Role of IGF2BP3 as a prognostic biomarker in chronic myeloid leukemia progression and disease stratification [0.03%]
IGF2BP3作为慢性髓系白血病进展和疾病分层的预后生物标志物的作用
Pragati Chauhan,Saba Ubaid,Mohammad Kashif et al.
Pragati Chauhan et al.
Background: Chronic Myeloid Leukemia (CML) progresses through chronic, accelerated, and blast crisis phases, posing challenges for disease stratification and predicting therapeutic response. IGF2BP3 (Insulin-like Growth F...
Oral CXCR4 inhibition with mavorixafor: Emerging therapeutic applications in WHIM syndrome, chronic neutropenia, oncology, and stem cell mobilization [0.03%]
口服CXCR4抑制剂马伏瑞沙芬在WHIM综合征、慢性中性粒细胞减少症、肿瘤学和造血干细胞动员中的新疗法及应用前景
Loi Huynh,Chi Huu Nguyen
Loi Huynh
The CXCR4/CXCL12 signaling axis plays a central role in regulating immune cell trafficking, hematopoietic homeostasis, and organogenesis. However, dysregulation of this axis contributes to the pathogenesis of numerous disorders, highlightin...
Identification of prognosis-related metabolism genes in hepatocellular carcinoma: constructing a multi-gene model for risk stratification [0.03%]
肝癌相关代谢基因的识别：构建风险分层多基因模型
Zihan Cai,Chunxiao Huang,Xiaomei Yi et al.
Zihan Cai et al.
Objective: Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with poor prognosis. This study identifies metabolism-related genes (MRGs) associated with HCC prognosis, develops a multi-gene prognostic model base...
Cladribine, low-dose cytarabine, and venetoclax in newly diagnosed and relapsed/refractory acute myeloid leukemia: A global perspective [0.03%]
新型及复发/难治性急性髓系白血病的克拉屈滨、低剂量阿糖胞苷和维奈克拉治疗：全球视角
Iman Abou Dalle,Abdallah Yassine,Ali Awada et al.
Iman Abou Dalle et al.
Purpose: The combination of cladribine (CLAD), low-dose cytarabine (LDAC), and venetoclax (CLAD-LDAC-venetoclax) has demonstrated promising efficacy in acute myeloid leukemia (AML) but remains underutilized globally. Sinc...
A comprehensive review on artificial intelligence driven approaches for vaccine development: Current advances, challenges, and future prospects [0.03%]
人工智能驱动的疫苗开发方法综述：当前进展、挑战和未来前景
Jyoti Gupta,Reetesh Kumar
Jyoti Gupta
Artificial intelligence (AI) has emerged as an exemplified tool in the field of modern biomedical technology. The unprecedent COVID-19 pandemic and other infectious disease crises have highlighted the critical need for rapid and accurate va...
Zesen Han,Mengpu Jin,Peisen Han et al.
Zesen Han et al.
Studies have shown that Helicobacter pylori (H. pylori) infection can induce chronic inflammation and immune responses in the gastric mucosa, potentially contributing to the development of lymphoma. To explore the association between H. pyl...