Optimizing CAR-T cell function in solid tumor microenvironment: insights from culture media additives [0.03%]
CAR-T细胞在实体瘤微环境中的功能优化：培养基添加剂带来的启示
Wenwen Chen,Luxia Xu,Zhigang Guo et al.
Wenwen Chen et al.
Cancer remains one of the most pressing health challenges worldwide. Recently, chimeric antigen receptor (CAR)-T cell therapy has emerged as a promising approach for treating hematological cancers. However, the translation of CAR-T cell the...
The impact of artificial intelligence and machine learning in organ retrieval and transplantation: A comprehensive review [0.03%]
人工智能和机器学习在器官获取和移植中的影响：全面回顾
David B Olawade,Sheila Marinze,Nabeel Qureshi et al.
David B Olawade et al.
This narrative review examines the transformative role of Artificial Intelligence (AI) and Machine Learning (ML) in organ retrieval and transplantation. AI and ML technologies enhance donor-recipient matching by integrating and analyzing co...
Accelerating CAR T cell manufacturing with an automated next-day process [0.03%]
一种自动化的CAR-T细胞次日制造流程及其应用
Moloud Ahmadi,Nicholas Putnam,Max Dotson et al.
Moloud Ahmadi et al.
The traditional method of CAR T cell production involves lengthy ex-vivo culture times which can result in the reduction of crucial naïve T cell subsets. Moreover, traditional CAR T cell therapy manufacturing processes can prolong time-to-...
Zixuan Wang,Guangji Zhang
Zixuan Wang
In recent years, chimeric antigen receptor (CAR) T-cell therapy has emerged as a groundbreaking approach in cancer immunotherapy. Particularly in hematologic malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL), B cell lymphoma...
Non-hematological triggers of VEXAS syndrome: A case report and literature review [0.03%]
VEXAS综合征的非血液学触发因素：一例报告及文献复习
Thibaud Loupret,Laurie De Coster,Camille Lemaçon et al.
Thibaud Loupret et al.
Sexual and emotional life among patients with hematological malignancy-Special concerns in low- and middle- income countries (LMICs) [0.03%]
血液系统恶性肿瘤患者的性生活与情感生活 特殊关注低收入和中等收入国家(LMICs)
Tamim Alsuliman,Paolo Musiu,Lugien AlAsadi et al.
Tamim Alsuliman et al.
DNMT3A-related overgrowth syndrome presenting with immune thrombocytopenic purpura [0.03%]
伴有免疫性血小板减少性紫癜的DNMT3A相关过度生长综合征
Abdullah Sezer,Öznur Kaya Güneş,Burçak Kurucu
Abdullah Sezer
Tatton-Brown-Rahman syndrome (TBRS) is characterized by overgrowth, cognitive deficiency, and distinctive facial features resulting from germline DNMT3A variants. This report describes a four-year-old female diagnosed with TBRS due to a de ...
CAR T-cell therapy combined with autologous hematopoietic cell transplantation in patients with refractory/relapsed Burkitt Lymphoma [0.03%]
用于治疗难治或复发伯基特淋巴瘤的CAR-T细胞疗法联合自体造血干细胞移植
Yifan Liu,Gangfeng Xiao,Yang Liu et al.
Yifan Liu et al.
Burkitt lymphoma (BL) is a highly aggressive type of non-Hodgkin lymphomas that have a high likelihood of relapse and are highly refractory to initial treatment. While high-intensity chemotherapy has improved the outcomes, many adult patien...
In silico analysis and structural vaccinology prediction of Toxoplasma gondii ROP41 gene via immunoinformatics methods as a vaccine candidate [0.03%]
基于免疫信息学方法的ROP41基因托拉杜里亚刚地食虫阿米巴原虫候选疫苗的计算机分析及结构疫苗学预测研究
Masoumeh Asadi,Ali Dalir Ghaffari,Fatemeh Mohammadhasani
Masoumeh Asadi
Introduction: Toxoplasma gondii (T. gondii) infects all warm-blooded animals, including humans. Currently, no effective treatments exist to prevent the generation of chronic tissue cysts in infected hosts. Therefore, deve...
Evaluation and management of hepatic dysfunction, portal hypertension and portal/splanchnic vein thrombosis in patients with myelofibrosis undergoing allogeneic haematopoietic cell transplantation: A practice based survey on behalf of the Chronic Malignancies Working Party of the EBMT [0.03%]
欧洲血液和骨髓移植慢性肿瘤工作组关于评价和管理异基因造血细胞移植后发生肝功能障碍、门脉高压及门静脉/肠系膜静脉血栓的我的纤维化患者的实践调查报告
Giorgia Battipaglia,Nicola Polverelli,Joe Tuffnell et al.
Giorgia Battipaglia et al.
Heterogeneous approaches exist in regard to the management of disease-related co-morbidities in potential allogeneic haematopoietic cell transplantation (allo-HCT) candidates with myelofibrosis (MF). The EBMT Chronic Malignancies Working Pa...