Extracting Complementary Insights from Molecular Phenotypes for Prioritization of Disease-Associated Mutations [0.03%]
从分子表型中提取互补见解以优先处理与疾病相关的突变
Shayne D Wierbowski,Robert Fragoza,Siqi Liang et al.
Shayne D Wierbowski et al.
Rapid advances in next-generation sequencing technology have resulted in an explosion of whole-exome/genome sequencing data, providing an unprecedented opportunity to identify disease- and trait-associated variants in humans on a large scal...
Applications of ENCODE data to Systematic Analyses via Data Integration [0.03%]
整合数据在系统分析中的ENCODE数据应用
Yanding Zhao,Evelien Schaafsma,Chao Cheng
Yanding Zhao
Large-scale genomic data have been utilized to generate unprecedented biological findings and new hypotheses. To delineate functional elements in the human genome, the Encyclopedia of DNA Elements (ENCODE) project has generated an enormous ...
Christian Zerfaß,Munehiro Asally,Orkun S Soyer
Christian Zerfaß
Metabolism is generally considered as a neatly organised system of modular pathways, shaped by evolution under selection for optimal cellular growth. This view falls short of explaining and predicting a number of key observations about the ...
A primer on pheromone signaling in Caenorhabditis elegans for systems biologists [0.03%]
简析系统生物学家们眼中的杆圆线虫信息素信号通路
Patrick T McGrath,Ilya Ruvinsky
Patrick T McGrath
Individuals communicate information about their age, sex, social status, and recent life history with other members of their species through the release of pheromones, chemical signals that elicit behavioral or physiological changes in the ...
Integration of large-scale multi-omic datasets: a protein-centric view [0.03%]
大规模多组学数据集的整合：以蛋白质为中心的观点
Justin Rendleman,Hyungwon Choi,Christine Vogel
Justin Rendleman
Innovative mass spectrometry-based proteomics has enabled routine measurements of protein abundance, localization, interactions, and modifications, covering unique aspects of gene expression regulation and function. It is now time to move f...
Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness [0.03%]
炎症与疾病：炎症反应的建模和调控以缓解重症病情
Judy D Day,Chase Cockrell,Rami Namas et al.
Judy D Day et al.
Critical illness, a constellation of interrelated inflammatory and physiological derangements occurring subsequent to severe infection or injury, affects a large number of individuals in both developed and developing countries. The prototyp...
Nikos Konstantinides,Sophie Degabriel,Claude Desplan
Nikos Konstantinides
The nervous system represents the most complex tissue in animals. How this complexity evolved has been a challenging question to address. The explosion in single cell sequencing techniques, the development of new algorithms to cluster singl...
Karl Kochanowski,Leanna Morinishi,Steven Altschuler et al.
Karl Kochanowski et al.
Drug-insensitive tumor subpopulations remain a significant barrier to effective cancer treatment. Recent works suggest that within isogenic drug-sensitive cancer populations, subsets of cells can enter a 'persister' state allowing them to s...
A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment [0.03%]
计算和数学模型对结核分枝杆菌体内感染及治疗的理解的影响综述
Denise Kirschner,Elsje Pienaar,Simeone Marino et al.
Denise Kirschner et al.
Tuberculosis (TB) is an ancient and deadly disease characterized by complex host-pathogen dynamics playing out over multiple time and length scales and physiological compartments. Computational modeling can be used to integrate various type...
Jimin Park,Harris H Wang
Jimin Park
Microbial gene regulatory networks are composed of cis- and trans-components that in concert act to control essential and adaptive cellular functions. Regulatory components and interactions evolve to adopt new configurations through mutatio...