Systems Virology at Scale [0.03%]
大规模系统病毒学研究
Cameron D Griffiths,Andrew J Sweatt,Kevin A Janes
Cameron D Griffiths
Today's subcellular and multicellular models of infection are poised to tackle bigger questions about virus-host interactions and the determinants of susceptibility. This opportunity comes from increased computing power, improved model arch...
Structural and practical identifiability of within-host models of virus dynamics - a review [0.03%]
病毒动力学的结构和实际可识别性-综述
Necibe Tuncer,Maia Martcheva,Stanca M Ciupe
Necibe Tuncer
Within-host mechanistic mathematical models of virus dynamics described by ordinary differential equations are most useful when linked to empirical data. The main challenge in estimating parameters from typically available, noisy data arise...
Microbial Production of Fuels, Commodity Chemicals, and Materials from Sustainable Sources of Carbon and Energy [0.03%]
利用可持续碳和能源资源生产燃料、商品化学品及材料的微生物技术
Aidan E Cowan,Sarah H Klass,Peter H Winegar et al.
Aidan E Cowan et al.
Anthropogenic carbon emissions are driving rapid changes to the earth's climate, disrupting whole ecosystems and endangering the stability of human society. Innovations in engineered microbial fermentation enable the fossil resource-free pr...
Jordan J A Weaver,Amber M Smith
Jordan J A Weaver
Host immune responses play a pivotal role in defending against influenza viruses. The activation of various immune components, such as interferon, macrophages, and CD8+ T cells, works to limit viral spread while maintaining lung integrity. ...
Kevin M Hannay,Jennette P Moreno
Kevin M Hannay
The emergence of wearable health sensors in the last decade has the potential to revolutionize the study of sleep and circadian rhythms. In particular, recent progress has been made in the use of mathematical models in the prediction of a p...
New faces of prokaryotic mobile genetic elements: guide RNAs link transposition with host defense mechanisms [0.03%]
新的原核生物移动遗传元件的面孔：引导RNA将转位与宿主防御机制联系在一起
Eugene V Koonin,Mart Krupovic
Eugene V Koonin
Most life forms harbor multiple, diverse mobile genetic elements (MGE) that widely differ in their rates and mechanisms of mobility. Recent findings on two classes of MGE in prokaryotes revealed a novel mechanism, RNA-guided transposition, ...
Teemu D Laajala,Travis Gerke,Svitlana Tyekucheva et al.
Teemu D Laajala et al.
Heterogeneity in tumors is recognized as a key contributor to drug resistance and spread of advanced disease, but deep characterization of genetic variation within tumors has only recently been quantifiable with the advancement of next gene...
Evolutionary implications of host genetic control for engineering beneficial microbiomes [0.03%]
宿主遗传控制对构建有益菌群的进化意义
Lucas P Henry,Joy Bergelson
Lucas P Henry
Engineering new functions in the microbiome requires understanding how host genetic control and microbe-microbe interactions shape the microbiome. One key genetic mechanism underlying host control is the immune system. The immune system can...
Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation [0.03%]
纳米尺度的核环境、精细的三维基因组组织与转录调控
Jieru Li,Alexandros Pertsinidis
Jieru Li
Decades of in vitro biochemical reconstitution, genetics and structural biology studies have established a vast knowledge base on the molecular mechanisms of chromatin regulation and transcription. A remaining challenge is to understand how...
T Dullweber,A Erzberger
T Dullweber
To reliably form and maintain structures with specific functions, many multicellular systems evolved to leverage the interplay between biochemical signaling, mechanics, and morphology. We review mechanochemical feedback loops in cases where...