Microbial Production of Fuels, Commodity Chemicals, and Materials from Sustainable Sources of Carbon and Energy [0.03%]
利用可持续碳和能源资源生产燃料、商品化学品及材料的微生物技术
Aidan E Cowan,Sarah H Klass,Peter H Winegar et al.
Aidan E Cowan et al.
Anthropogenic carbon emissions are driving rapid changes to the earth's climate, disrupting whole ecosystems and endangering the stability of human society. Innovations in engineered microbial fermentation enable the fossil resource-free pr...
Jordan J A Weaver,Amber M Smith
Jordan J A Weaver
Host immune responses play a pivotal role in defending against influenza viruses. The activation of various immune components, such as interferon, macrophages, and CD8+ T cells, works to limit viral spread while maintaining lung integrity. ...
Kevin M Hannay,Jennette P Moreno
Kevin M Hannay
The emergence of wearable health sensors in the last decade has the potential to revolutionize the study of sleep and circadian rhythms. In particular, recent progress has been made in the use of mathematical models in the prediction of a p...
New faces of prokaryotic mobile genetic elements: guide RNAs link transposition with host defense mechanisms [0.03%]
新的原核生物移动遗传元件的面孔：引导RNA将转位与宿主防御机制联系在一起
Eugene V Koonin,Mart Krupovic
Eugene V Koonin
Most life forms harbor multiple, diverse mobile genetic elements (MGE) that widely differ in their rates and mechanisms of mobility. Recent findings on two classes of MGE in prokaryotes revealed a novel mechanism, RNA-guided transposition, ...
Teemu D Laajala,Travis Gerke,Svitlana Tyekucheva et al.
Teemu D Laajala et al.
Heterogeneity in tumors is recognized as a key contributor to drug resistance and spread of advanced disease, but deep characterization of genetic variation within tumors has only recently been quantifiable with the advancement of next gene...
Evolutionary implications of host genetic control for engineering beneficial microbiomes [0.03%]
宿主遗传控制对构建有益菌群的进化意义
Lucas P Henry,Joy Bergelson
Lucas P Henry
Engineering new functions in the microbiome requires understanding how host genetic control and microbe-microbe interactions shape the microbiome. One key genetic mechanism underlying host control is the immune system. The immune system can...
Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation [0.03%]
纳米尺度的核环境、精细的三维基因组组织与转录调控
Jieru Li,Alexandros Pertsinidis
Jieru Li
Decades of in vitro biochemical reconstitution, genetics and structural biology studies have established a vast knowledge base on the molecular mechanisms of chromatin regulation and transcription. A remaining challenge is to understand how...
T Dullweber,A Erzberger
T Dullweber
To reliably form and maintain structures with specific functions, many multicellular systems evolved to leverage the interplay between biochemical signaling, mechanics, and morphology. We review mechanochemical feedback loops in cases where...
Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight? [0.03%]
隐匿在免疫球蛋白基因中的易感性遗传因素？
Andrew M Collins,Gur Yaari,Adrian J Shepherd et al.
Andrew M Collins et al.
Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no lon...
The Microbiome and Big Data [0.03%]
微生态与大数据技术
Jose A Navas-Molina,Embriette R Hyde,Jon Sanders et al.
Jose A Navas-Molina et al.
Microbiome datasets have expanded rapidly in recent years. Advances in DNA sequencing, as well as the rise of shotgun metagenomics and metabolomics, are producing datasets that exceed the ability of researchers to analyze them on their pers...