How to find the right drug for each patient? Advances and challenges in pharmacogenomics [0.03%]
如何为每位患者找到合适的药物？药物基因组学领域的进展与挑战
Angeliki Kalamara,Luis Tobalina,Julio Saez-Rodriguez
Angeliki Kalamara
Cancer is a highly heterogeneous disease with complex underlying biology. For these reasons, effective cancer treatment is still a challenge. Nowadays, it is clear that a cancer therapy that fits all the cases cannot be found, and as a resu...
Amber M Smith
Amber M Smith
Viruses are a main cause of disease worldwide and many are without effective therapeutics or vaccines. A lack of understanding about how host responses work to control viral spread is one factor limiting effective management. How different ...
Biological signal generators: integrating synthetic biology tools and in silico control [0.03%]
生物信号发生器：整合合成生物学工具和计算机控制模型
Taylor D Scott,Kieran Sweeney,Megan N McClean
Taylor D Scott
Biological networks sense extracellular stimuli and generate appropriate outputs within the cell that determine cellular response. Biological signal generators are becoming an important tool for understanding how information is transmitted ...
Ziwei Zhong,Chang C Liu
Ziwei Zhong
Jason W Locasale
Jason W Locasale
Glycolysis, the breakdown of glucose, is one of the most conserved and extensively studied biochemical pathways. Designing principles from chemistry and thermodynamics allow for energy production, biosynthesis and cellular communication. Ho...
Understanding cellular signaling and systems biology with precision: A perspective from ultrastructure and organelle studies in the Drosophila midgut [0.03%]
从果蝇肠道中超微结构及细胞器研究看信号转导和系统生物学的精准性
Chiwei Xu,Maria Ericsson,Norbert Perrimon
Chiwei Xu
One of the aims of systems biology is to model and discover properties of cells, tissues and organisms functioning as a system. In recent years, studies in the adult Drosophila gut have provided a wealth of information on the cell types and...
Cell-machine interfaces for characterizing gene regulatory network dynamics [0.03%]
用于表征基因调控网络动态的细胞机器界面
Jean-Baptiste Lugagne,Mary J Dunlop
Jean-Baptiste Lugagne
Gene regulatory networks and the dynamic responses they produce offer a wealth of information about how biological systems process information about their environment. Recently, researchers interested in dissecting these networks have been ...
Sonia Singhal,Shawn M Gomez,Christina L Burch
Sonia Singhal
Recombination can impose fitness costs as beneficial parental combinations of alleles are broken apart, a phenomenon known as recombination load. Computational models suggest that populations may evolve a reduced recombination load by reduc...
Jessica M Conway,Ruy M Ribeiro
Jessica M Conway
The interplay between immune response and HIV is intensely studied via mathematical modeling, with significant insights but few direct answers. In this short review, we highlight advances and knowledge gaps across different aspects of immun...
The expanding role of systems immunology in decoding the T cell receptor repertoire [0.03%]
系统免疫学在解码T细胞受体ertoire方面的应用日益广泛
Vanessa Venturi,Paul G Thomas
Vanessa Venturi
T cells play a crucial role in the immune system's defense against many infectious diseases, including persistent infections for which no effective vaccines currently exist. The T cell component of the adaptive immune system is highly compl...