Sreeja K Kandy,Paul A Janmey,Ravi Radhakrishnan
Sreeja K Kandy
We opine on the recent advances in experiments and modeling of modular signaling complexes assembled on mammalian cell membranes (membrane signalosomes) in the context of several applications including intracellular trafficking, cell migrat...
The landscape of cell-cell communication through single-cell transcriptomics [0.03%]
单细胞转录组学视角下的细胞通讯景观
Axel A Almet,Zixuan Cang,Suoqin Jin et al.
Axel A Almet et al.
Cell-cell communication is a fundamental process that shapes biological tissue. Historically, studies of cell-cell communication have been feasible for one or two cell types and a few genes. With the emergence of single-cell transcriptomics...
Order by chance: origins and benefits of stochasticity in immune cell fate control [0.03%]
机遇排序：免疫细胞命运控制中随机性的起源及益处
Kathleen Abadie,Nicholas A Pease,Matthew J Wither et al.
Kathleen Abadie et al.
To protect against diverse challenges, the immune system must continuously generate an arsenal of specialized cell types, each of which can mount a myriad of effector responses upon detection of potential threats. To do so, it must generate...
Data integration for inferring context-specific gene regulatory networks [0.03%]
数据集成在推断特定条件下的基因调控网络中的应用
Brittany Baur,Junha Shin,Shilu Zhang et al.
Brittany Baur et al.
Transcriptional regulatory networks control context-specific gene expression patterns and play important roles in normal and disease processes. Advances in genomics are rapidly increasing our ability to measure different components of the r...
Djenet Bousbaine,Hidde L Ploegh
Djenet Bousbaine
The adaptive immune system has evolved to recognize with incredible precision a large diversity of molecules. Innovations in high-throughput sequencing and bioinformatics have accelerated large-scale immune repertoire analyses and given us ...
Julia Zeitlinger
Julia Zeitlinger
Genomics data are now being generated at large quantities, of exquisite high resolution and from single cells. They offer a unique opportunity to develop powerful machine learning algorithms, including neural networks, to uncover the rules ...
Nicholas C Curtis,Jiwon Lee
Nicholas C Curtis
Recent advancements in paired B-cell receptor sequencing technologies have accelerated the development of simpler, high-throughput pipelines for generating native antibody heavy and light chain pairs used to elucidate novel antibodies and p...
The adaptive immune receptor repertoire community as a model for FAIR stewardship of big immunology data [0.03%]
适应性免疫受体库研究社区作为大型免疫学数据FAIR管理的模型
Jamie K Scott,Felix Breden
Jamie K Scott
Systems biology involves network-oriented, computational approaches to modeling biological systems through analysis of big biological data. To contribute maximally to scientific progress, big biological data should be FAIR: findable, access...
Budding yeast as a factory to engineer partial and complete microbial genomes [0.03%]
芽殖酵母作为工程化微生物部分及完整基因组的工厂
Sanjay Vashee,Yonathan Arfi,Carole Lartigue
Sanjay Vashee
Yeast cells have long been used as hosts to propagate exogenous DNA. Recent progress in genome editing opens new avenues in synthetic biology. These developments allow the efficient engineering of microbial genomes in Saccharomyces cerevisi...
Giuseppe Facchetti,Fred Chang,Martin Howard
Giuseppe Facchetti
Cell size is partly determined through coordination between cell growth and division. How this coordination is achieved mechanistically remains mostly unknown. However, quantitative experiments together with computational modelling have rei...