Mechanistic models of blood cell fate decisions in the era of single-cell data [0.03%]
单细胞数据分析时代中的血细胞命运决定机制模型
Ingmar Glauche,Carsten Marr
Ingmar Glauche
Billions of functionally distinct blood cells emerge from a pool of hematopoietic stem cells in our bodies every day. This progressive differentiation process is hierarchically structured and remarkably robust. We provide an introductory re...
Bacterial two-component systems as sensors for synthetic biology applications [0.03%]
合成生物学应用的细菌两组分系统传感器
John T Lazar,Jeffrey J Tabor
John T Lazar
Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that enable bacteria to sense and respond to diverse physical, chemical, and biological stimuli outside and inside the cell. Synthetic biologists have begu...
Stanislav Drapela,Ana P Gomes
Stanislav Drapela
Metastases represent a major cause of cancer-associated deaths. Despite extensive research, targeting metastasis remains the main obstacle in cancer therapy. Therefore, it is of tremendous importance to elucidate the mechanisms that impinge...
Cell-Cell Communication Networks in Tissue: Toward Quantitatively Linking Structure with Function [0.03%]
组织中的细胞间通讯网络：量化结构与功能之间的联系
Gaurav Luthria,Douglas Lauffenburger,Miles A Miller
Gaurav Luthria
Forefront techniques for molecular interrogation of mammalian tissues, such as multiplexed tissue imaging, intravital microscopy, and single-cell RNA sequencing (scRNAseq), can combine to quantify cell-type abundance, co-localization, and g...
Forecasting cellular states: from descriptive to predictive biology via single-cell multiomics [0.03%]
预测细胞状态：通过单细胞多组学从描述性生物学转向预测性生物学
Genevieve L Stein-O&#x;Brien,Michaela C Ainsile,Elana J Fertig
Genevieve L Stein-O&#x;Brien
As the single cell field races to characterize each cell type, state, and behavior, the complexity of the computational analysis approaches the complexity of the biological systems. Single cell and imaging technologies now enable unpreceden...
Measurements drive progress in directed evolution for precise engineering of biological systems [0.03%]
测量推动定向进化在生物系统精密工程中的进展
Drew S Tack,Eugenia F Romantseva,Peter D Tonner et al.
Drew S Tack et al.
Precise engineering of biological systems requires quantitative, high-throughput measurements, exemplified by progress in directed evolution. New approaches allow high-throughput measurements of phenotypes and their corresponding genotypes....
Design and development of engineered receptors for cell and tissue engineering [0.03%]
用于细胞和组织工程的工程受体的设计与开发
Shwan B Javdan,Tara L Deans
Shwan B Javdan
Advances in synthetic biology have provided genetic tools to reprogram cells to obtain desired cellular functions that include tools to enable the customization of cells to sense an extracellular signal and respond with a desired output. Th...
Kate E Dray,Hailey I Edelstein,Kathleen S Dreyer et al.
Kate E Dray et al.
Synthetic biology increasingly enables the construction of sophisticated functions in mammalian cells. A particularly promising frontier combines concepts drawn from industrial process control engineering-which is used to confer and balance...
Alexander L R Lubbock,Carlos F Lopez
Alexander L R Lubbock
Computational modeling has become an established technique to encode mathematical representations of cellular processes and gain mechanistic insights that drive testable predictions. These models are often constructed using graphical user i...
Current progress and potential opportunities to infer single-cell developmental trajectory and cell fate [0.03%]
单细胞发育轨迹和细胞命运推断的最新进展和潜在机会
Lingfei Wang,Qian Zhang,Qian Qin et al.
Lingfei Wang et al.
Rapid technological advances in transcriptomics and lineage tracing technologies provide new opportunities to understand organismal development at the single-cell level. Building on these advances, various computational methods have been pr...