Budhaditya Banerjee,Richard I Sherwood
Budhaditya Banerjee
Due to plummeting costs, whole genome sequencing of patients and cancers will soon become routine medical practice; however, we cannot currently predict how non-coding genotype affects cellular gene expression. Gene regulation research has ...
Integrating genomic information and signaling dynamics for efficient cancer therapy [0.03%]
整合基因组信息和信号动力学以实现高效的癌症治疗
Jacob Stewart-Ornstein,Galit Lahav
Jacob Stewart-Ornstein
The field of cancer systems biology has made great strides in understanding oncogenic pathway signaling and enumerating mutations involved in oncogenesis. However, application of these datasets to patient stratification, and to the design o...
From perception to action in songbird production: dynamics of a whole loop [0.03%]
从感知到鸣禽发声的行为：整个回路的动力学现象
Ana Amador,Santiago Boari,Gabriel B Mindlin
Ana Amador
Birdsong emerges when a set of highly interconnected brain areas manage to generate a complex output. This consists of precise respiratory rhythms as well as motor instructions to control the vocal organ configuration. In this way, during b...
Network-based approaches that exploit inferred transcription factor activity to analyze the impact of genetic variation on gene expression [0.03%]
基于推断的转录因子活性利用网络方法分析遗传变异对基因表达的影响
Harmen J Bussemaker,Helen C Causton,Mina Fazlollahi et al.
Harmen J Bussemaker et al.
Over the past decade, a number of methods have emerged for inferring protein-level transcription factor activities in individual samples based on prior information about the structure of the gene regulatory network. We discuss how this has ...
Derek E Kelly,Matthew E B Hansen,Sarah A Tishkoff
Derek E Kelly
The genomics era has accelerated our understanding of how genetic and epigenetic factors influence both normal variable traits and disease risk in humans. However, the majority of "omics" studies have focused on individuals living in urban ...
Population Epigenetics [0.03%]
人群表观遗传学
John M Greally
John M Greally
The field of epigenetics is maturing, with increased interest in understanding the normal regulation of the genome and the possibility that it becomes reprogrammed aberrantly as part of the cause of disease phenotypes. Applying the current ...