Christopher Abbosh,Subramanian Venkatesan,Samuel M Janes et al.
Christopher Abbosh et al.
Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minorit...
Jolanda van Leeuwen,Charles Boone,Brenda J Andrews
Jolanda van Leeuwen
Genetic interactions occur when the combination of multiple mutations yields an unexpected phenotype, and they may confound our ability to fully understand the genetic mechanisms underlying complex diseases. Genetic interactions are challen...
Adam L MacLean,Tian Hong,Qing Nie
Adam L MacLean
As our catalog of cell states expands, appropriate characterization of these states and the transitions between them is crucial. Here we discuss the roles of intermediate cell states (ICSs) in this growing collection. We begin with definiti...
Maelle Bellec,Ovidiu Radulescu,Mounia Lagha
Maelle Bellec
During development, transcriptional properties of progenitor cells are stably propagated across multiple cellular divisions. Yet, at each division, chromatin faces structural constraints imposed by the important nuclear re-organization oper...
Transdifferentiation: do transition states lie on the path of development? [0.03%]
转分化：转化状态位于发育路径上吗？
Anna Reid,Baris Tursun
Anna Reid
The direct conversion of one differentiated cell fate into another identity is a process known as Transdifferentiation. During Transdifferentiation, cells pass through intermediate states that are not well understood. Given the potential ap...
Tawny N Cuykendall,Mark A Rubin,Ekta Khurana
Tawny N Cuykendall
The vast majority of somatic variants in cancer genomes occur in non-coding regions. However, progress in cancer genomics in the past decade has been mostly focused on coding regions, largely due to the prohibitive cost of whole genome sequ...
Genome Stability during Cell Proliferation: A Systems Analysis of the Molecular Mechanisms Controlling Progression through the Eukaryotic Cell Cycle [0.03%]
细胞增殖过程中的基因组稳定性：对控制真核生物细胞周期进展的分子机制进行系统分析
Béla Novák,Frank Stefan Heldt,John J Tyson
Béla Novák
Well-nourished cells in a favorable environment (well supplied with growth factors, cytokines, and/or hormones and free from stresses, ionizing radiation, etc.) will grow, replicate their genome, and divide into two daughter cells, fully pr...
Christian Scheeder,Florian Heigwer,Michael Boutros
Christian Scheeder
The increase in imaging throughput, new analytical frameworks and high-performance computational resources open new avenues for data-rich phenotypic profiling of small molecules in drug discovery. Image-based profiling assays assessing sing...
Tiffany Chien,Anjali Doshi,Tal Danino
Tiffany Chien
Synthetic biology aims to apply engineering principles to biology by modulating the behavior of living organisms. An emerging application of this field is the engineering of bacteria as a cancer therapy by the programming of therapeutic, sa...
Cesar A Vargas-Garcia,Khem Raj Ghusinga,Abhyudai Singh
Cesar A Vargas-Garcia
Growth of a cell and its subsequent division into daughters is a fundamental aspect of all cellular living systems. During these processes, how do individual cells correct size aberrations so that they do not grow abnormally large or small?...