Ali J Marian
Ali J Marian
Genetic variants are major determinants of susceptibility to disease, response to therapy, and clinical outcomes. Advances in the short-read sequencing technologies, despite some shortcomings, have enabled identification of the vast majorit...
Proteolysis of Von Willebrand Factor Influences Inflammatory Endothelial Activation and Vascular Compliance in Atherosclerosis [0.03%]
蛋白水解对血管壁维利勃兰特因子、炎症活化和血管弹性的影响作用于动脉粥样硬化中的作用机制研究
Koya Ozawa,Matthew A Muller,Oleg Varlamov et al.
Koya Ozawa et al.
This study used in vivo molecular imaging to characterize endotheliall activation attributable to von Willebrand factor (vWF)-mediated platelet adhesion in atherosclerosis. In atherosclerotic mice lacking the low-density lipoprotein recepto...
Mitral Butterfly: Preclinical Experience of a Novel Chordal Repair Device Using an Artificial Papillary Muscle [0.03%]
一种新型人工乳头肌腱索修复装置的临床前研究：机械性能和解剖学表现
Johanna M Ticar,Gediminas Gaidulis,Kenzie Veith et al.
Johanna M Ticar et al.
Transcatheter mitral repair is based on the principle of artificial monochordal repair. In this paper, the authors show an alternative, based on the realization of an artificial papillary muscle concept that avoids multiple chordal replacem...
Septal Reduction Using Transvenous Intramyocardial Cerclage Radiofrequency Ablation: Preclinical Feasibility [0.03%]
经静脉心肌环形消融束支起搏器的室间隔减容术：可行性研究
Eun-Seok Shin,Min-Ku Chon,Eun Jung Jun et al.
Eun-Seok Shin et al.
Debulking of left ventricular septal mass is typically accomplished using surgical myectomy, which is morbid, or using transcoronary alcohol septal ablation, which can result in geographic miss and occasional catastrophic nontarget coronary...
Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure [0.03%]
人类背根神经节刺激可减少交感神经传出和长期血压值
Yrsa B Sverrisdottir,Sean C Martin,George Hadjipavlou et al.
Yrsa B Sverrisdottir et al.
This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity during ON and OFF stimulation ...
In the Age of COVID: Genomic Changes Over the Lifespan Help Explain Severe SARS-CoV-2 Disease [0.03%]
新冠肺炎时代：生命周期中的基因组变化有助于解释严重的新冠病毒疾病
Brandon J Beddingfield,Gregory J Bix
Brandon J Beddingfield
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection [0.03%]
一种整合素结合肽ATN-161作为治疗SARS-CoV-2感染的新方法
Brandon J Beddingfield,Naoki Iwanaga,Prem P Chapagain et al.
Brandon J Beddingfield et al.
Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting angiotensin-converting enzyme-2 (ACE2) bindi...
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells [0.03%]
心脏肾脏组织表达SARS-CoV-2的入侵基因和基根（BSG / CD147）随着内皮细胞年龄的增长而增加
Blerina Ahmetaj-Shala,Ricky Vaja,Santosh S Atanur et al.
Blerina Ahmetaj-Shala et al.
Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors fo...
Eric M Small,Alan C Brooks
Eric M Small
Trimming the Fat in HFpEF: Learning How to Target the Metabolic Disease Phenotype [0.03%]
HFpEF中的减肥手术：学习如何针对代谢疾病表型进行治疗
Joel D Schilling
Joel D Schilling