FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease [0.03%]
FOXC1调控血管疾病中的平滑肌细胞分化和转分化现象
Urszula Rykaczewska,Bianca E Suur,Sampath Narayanan et al.
Urszula Rykaczewska et al.
Smooth muscle cell-related transcription factors have been associated with coronary artery disease in large genome-wide association studies, increasing their translational value for therapeutic investigations. Our study shows for the first ...
Eduardo Marbán
Eduardo Marbán
Paul Spangler,Thea Bommer,Laura Stengel et al.
Paul Spangler et al.
Ventricular arrhythmias and sudden cardiac death are a leading cause of death in patients with atrial fibrillation (AF). This study investigated how AF promotes ventricular arrhythmias. Cellular electrophysiology of AF patients was characte...
Mendelian Randomization Reveals Interleukin-6 Receptor-Lipoprotein(a) Interplay With Independent Cardiovascular Risk Reductions [0.03%]
孟德尔随机化揭示白细胞介素-6受体与脂蛋白(a)的相互作用及其独立的心血管风险降低作用
Azin Kheirkhah,Silvia Di Maio,Stefan Coassin et al.
Azin Kheirkhah et al.
In the study at hand, 2-sample Mendelian randomization supported a causal effect of interleukin-6 receptor (IL-6R) signaling on Lp(a) concentrations, revealing a direct interplay between 2 causal risk factors for cardiovascular disease (CVD...
LDLR-OPN Interaction Drives COVID-19 Myocarditis Through Monocyte Recruitment [0.03%]
LDLR-OPN相互作用通过单核细胞募集驱动COVID-19心肌炎
Jose Manuel Condor Capcha,Emely Robleto,Nadia Martinez Naya et al.
Jose Manuel Condor Capcha et al.
COVID-19-associated myocarditis is marked by macrophage-rich inflammation and adverse cardiac outcomes, yet its mechanisms remain unclear. We developed a reproducible BSL-2 mouse model by combining cardiac-specific human low-density lipopro...
Semaglutide Reverses Ectopic Lipid Accumulation, Impaired Myocardial Perfusion Reserve, and Diastolic Dysfunction in a Mouse Model of Cardiometabolic Heart Disease [0.03%]
塞马鲁肽逆转心代谢性疾病小鼠模型中的异位脂质蓄积、心肌血流量储备障碍和舒张功能障碍
Thomas P Skacel,Nemati R Saleh,Caitlin M Pavelec et al.
Thomas P Skacel et al.
Semaglutide (SEMA) improves cardiometabolic outcomes in obesity, but its mechanisms remain incompletely understood. We examined the effects of SEMA in mice fed a high-fat, high-sucrose diet. Obese mice were treated with SEMA and compared wi...
Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy [0.03%]
心律失常性心肌病中白细胞介素-1β驱动疾病进展
Vinay R Penna,Junedh M Amrute,Morgan Engel et al.
Vinay R Penna et al.
Arrhythmogenic cardiomyopathy (ACM) is a genetic form of heart failure that affects 1 in 5,000 people globally and is caused by mutations in cardiac desmosomal genes including PKP2, DSP, and DSG2. Individuals with ACM suffer from ventricula...
Targeted Intra-Atrial Delivery of GMP-Grade Human Extracellular Vesicles Prevents Inflammation-Driven Postoperative Atrial Fibrillation in Pigs [0.03%]
人外泌体GMP产品靶向投递至心房内能预防猪发生炎症相关术后房颤
Noreen Ahmed,Sandrine Parent,Charlotte A René et al.
Noreen Ahmed et al.
Targeted intra-atrial delivery of GMP-grade human cardiac extracellular vesicles (EVs) was evaluated for prevention of postoperative atrial fibrillation (AF). EVs were manufactured under serum-free, xenogen-free GMP-compatible conditions an...
Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy [0.03%]
系统生物学鉴定出TARS2是扩张型心肌病心肌细胞线粒体氧化应激的调节因子
Liming Chen,Xuan Li,Xiaolei Sun et al.
Liming Chen et al.
Dilated cardiomyopathy (DCM), a leading cause of heart failure, is characterized by progressive cardiomyocyte (CM) loss and mitochondrial dysfunction; yet, the molecular drivers of mitochondrial oxidative stress (MitOS) remain unclear. By i...
Cardiomyocyte-Derived Apelin Rescues Viral Myocarditis-Induced Cardiac Lymphatic Dysfunction and Remodeling [0.03%]
心肌细胞源性阿佩林可修复病毒性心肌炎引起的心脏淋巴管功能障碍和重构
Yuan-Nan Lin,Jing Xu,Yi-Hao Wu et al.
Yuan-Nan Lin et al.
Recent research has indicated that cardiac lymphatic vessels (CLVs) serve as a direct drainage route into the mediastinal lymph nodes for inflammation resolution. However, the role of CLVs in coxsackievirus B3-induced acute viral myocarditi...