A Novel Perspective on a Genetically Altered Model of SARS-CoV-2 Myocarditis: The LDLR-OPN Axis [0.03%]
SARS-CoV-2心肌炎基因改变模型的新视角：LDLR-OPN轴
Madeleine W Cunningham,Leslie T Cooper Jr
Madeleine W Cunningham
Michal Mokry
Michal Mokry
Yosu Luque Rincon
Yosu Luque Rincon
RetiMap: Automated Retinal Vascular Measures Link Microvascular Structure to Metabolic Health and Predict Cardiovascular Risk [0.03%]
基于视网膜血管的代谢健康和心血管风险的预测模型
Yeela Talmor-Barkan,Michal Shapira,Smadar Shilo et al.
Yeela Talmor-Barkan et al.
Fundus imaging enables noninvasive, high-resolution visualization of the retinal microvasculature. Advances in artificial intelligence (AI) now allow for extraction of quantitative vascular metrics from retinal images, offering new opportun...
Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy [0.03%]
吡格列酮及其R对映体通过靶向炎症减轻小鼠肥厚型心肌病的病理性心室重构
Anna-Theresa Pfaller,Claudia Veneziano,Sarala Raj Murthi et al.
Anna-Theresa Pfaller et al.
Hypertrophic cardiomyopathy (HCM) is driven by sarcomeric mutations that cause energetic failure and secondary inflammation. This study demonstrates that targeting this metabolic-inflammatory axis with pioglitazone or its peroxisome prolife...
Emerging Role of Sodium-Glucose Cotransporter-2 Inhibitors in Aortic Stenosis [0.03%]
钠葡萄糖共转运体2抑制剂在主动脉瓣狭窄中作用的初步探讨
Piotr Mazur,Magdalena Kopytek,Joanna Natorska
Piotr Mazur
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as a key drug class in the management of heart failure, expanding far beyond their original use in type 2 diabetes mellitus. Aortic stenosis (AS), the most common valvular heart...
Accelerated Turnover of Collagens and Other Extracellular Matrix Proteins Upon Chronic Beta-Adrenergic Stimulation [0.03%]
慢性β肾上腺素刺激下胶原蛋白和其他细胞外基质蛋白的加速周转
Matthew C Juber,Jacob G Cox,Thalia Paiz et al.
Matthew C Juber et al.
Synergistic Effects of SGLT2 Inhibitors and GLP-1R Agonists on Inflammation-Associated Oxidative Stress in Atrial Fibrillation [0.03%]
SGLT2抑制剂和GLP-1受体激动剂在心房颤动炎性相关氧化应激中的协同作用
Walaa Fakih,Ali Mroueh,Shinnosuke Kikuchi et al.
Walaa Fakih et al.
Atrial fibrillation (AF) is linked to atrial inflammation and adverse remodeling. The authors analyzed 80 right atrial appendages from cardiac surgery patients, including 18 with AF history, to examine the relationship between inflammation ...
Prolonged Inflammation Associates With Greater Infarct Size and Poor Outcome After ST-Segment Elevation Myocardial Infarction [0.03%]
持续的炎症与ST段抬高型心肌梗死后更大的梗死面积和不良结局有关
Christian Graesser,Johannes Krefting,Marius Schwab et al.
Christian Graesser et al.
Aims: Acute myocardial infarction (MI) induces a systemic inflammatory response that usually resolves within days, but the prognostic impact of persistent inflammation is uncertain. We assessed whether sustained leukocyto...
Cardiorenal Hemodynamic Coupling: Mechanical Circulatory Support Augments Renal Blood Flow via Renal Vasodilation [0.03%]
心脏肾血流动力学耦合：机械循环支持通过肾脏血管舒张增加肾血流量
Rachel E Zale,Elazer R Edelman
Rachel E Zale
Robust cardiorenal hemodynamic coupling influences outcomes in cardiogenic shock (CS), with concomitant renal failure a persistent challenge despite the use of mechanical circulatory support (MCS). The authors investigated cardiorenal hemod...