Matthias Nahrendorf,Clinton Robbins
Matthias Nahrendorf
Improving Detection of Peripheral Arterial Disease: cFAS a Serum Biomarker [0.03%]
一种新的血液生物标志物能够改善外周动脉疾病的检测能力：cFAS
Frank M Davis
Frank M Davis
A Revolutionizing Turn in Gene Delivery: Percutaneous Closed-Loop Perfusion Ushers in Precision Therapy [0.03%]
基因传递方式革新：经皮封闭灌注精准治疗即将到来
Atta Behfar,Zhang Bin,Yalamuri Suraj
Atta Behfar
Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure [0.03%]
肌球蛋白调节剂Aficamten通过改变肌球蛋白的生化活性而不是改变粗丝结构来抑制力量
Saffie Mohran,Kristina B Kooiker,Ateeqa Naim et al.
Saffie Mohran et al.
We investigated the effects of aficamten on cardiac muscle structure, biochemical activity, and contractile function. Aficamten does not structurally sequester myosin heads along the thick filament. It inhibits ATPase activity by decreasing...
The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support [0.03%]
心室机械卸载和循环支持介导的心肌恢复中的鞘脂的作用
Rana Hamouche,Sean M Tatum,Elizabeth Dranow et al.
Rana Hamouche et al.
Myocardial recovery after left ventricular assist device (LVAD) support is a critical phenomenon that allows advanced heart failure patients to retain their native heart. We quantified targeted sphingolipids in serum and cardiac tissue of p...
Emerging Role of Tet2 in the Regulation of Vascular Smooth Muscle Cell Identity During Arterial Calcification [0.03%]
Tet2在动脉钙化过程中调控血管平滑肌细胞身份的作用机制研究
Marie Piollet,Clément Cochain
Marie Piollet
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease [0.03%]
药理学增强应激反应综合症在钙化主动脉瓣疾病中的保护作用
Libo Wang,Xulei Duan,Huibing Liu et al.
Libo Wang et al.
Previous studies have shown that Nox4 activates eIF2α/ATF4 signaling during the integrated stress response (ISR) and protects heart injury. However, their roles in calcific aortic valve disease (CAVD) remain unclear. Here, we show that bot...
Epigenetic Reprogramming via TET2 Prevents Medial Calcification and Restores Vascular Smooth Muscle Cell Identity [0.03%]
TET2表观遗传重编程可防止中膜钙化并恢复血管平滑肌细胞身份
Bob S L Lee,Joshua K Dunn,Cassandra Liang et al.
Bob S L Lee et al.
Vascular calcification arises from the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and is a hallmark of many cardiovascular pathologies. This study identifies Tet2, a DNA demethylase, as a critical epigenetic reg...
JACC: Basic to Translational Science: Honoring the Top Reviewers of 2024 [0.03%]
JACC基础到转化科学：表彰2024年杰出审稿人
Brian H Annex,Michael R Bristow,Nikolaus G Frangogiannis et al.
Brian H Annex et al.
CD14 Blockade, A Next-Generation, Anti-Inflammatory Biological for Post-MI Remodeling [0.03%]
抗炎生物制剂CD14阻断剂用于心梗后的心室重构
Douglas G Tilley,Jop H van Berlo
Douglas G Tilley