ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity [0.03%]
ICG-001对多柔比星致心脏毒性的保护作用并增强抗癌细胞毒性作用
Binbin Wu,Jack C H Chen,Chloe H Y Ma et al.
Binbin Wu et al.
Doxorubicin is effective against cancer but can cause doxorubicin-induced cardiotoxicity (DCT). Drug discovery efforts against DCT are hampered by the need to balance cardioprotection and cancer control. This study demonstrates that ICG-001...
Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions [0.03%]
人类左心室circRNA-miRNA-mRNA网络分析揭示了缺血条件下circNPHP1的促血管生成作用
Maryam Anwar,Moumita Sarkar,Kerrie Ford et al.
Maryam Anwar et al.
Therapies promoting microvascular flow and endothelial repair require effective identification of new targets in ischemic heart disease (IHD). The aim of this study was to unravel and functionally investigate circular RNA (circRNA)-microRNA...
Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability To Cause Aortopathy [0.03%]
活化PRKG1基因变异增强平滑肌细胞变形能力引起主动脉病态變態
Marie E Jost,Moyra Schweizer,Philipp Henning et al.
Marie E Jost et al.
Aortic dissection can strike without warning. Whereas the condition is typically linked to aging and chronic hypertension, rare genetic variants emerge as silent culprits. One variant, V219I in PRKG1, has been found in patients with aortic ...
Runx1 in Postn-Expressing Fibroblasts But Not Cardiomyocytes Exacerbates Adverse Cardiac Remodeling Post Myocardial Infarction [0.03%]
成纤维细胞而非心肌细胞中 Runx1 在心肌梗死后加重心脏不良重塑
Kaelin A Akins,Anooj Arkatkar,Michael A Flinn et al.
Kaelin A Akins et al.
Runx1 is strongly induced in the heart after acute injury and in chronic disease settings. Its expression negatively correlates with outcomes, and past work demonstrates a protective effect when Runx1 is inhibited through a variety of exper...
Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis [0.03%]
心肌炎和慢性心肌炎中 cardiopathogenic T 细胞决定病情进展与功能重塑
Anna Joachimbauer,Nadine Cadosch,Cristina Gil-Cruz et al.
Anna Joachimbauer et al.
Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell-mediated myocardial inflammation and edematous swelling in subepicardial regions at ...
Selective Estrogen Receptor Degraders Induce Bradycardia by Modulating Nuclear Estrogen Signaling [0.03%]
选择性雌激素受体降解剂通过调节核内雌激素信号诱导心动过缓
Sandeep Basu,Andrea Nathalie Rosas Diaz,Jose Max Narvaez-Paliza et al.
Sandeep Basu et al.
Selective estrogen receptor degraders (SERDs) are emerging therapies for estrogen receptor-positive (ER+) breast cancer. However, certain oral SERDs, including giredestrant and camizestrant, have been associated with bradycardia in clinical...
Lipoprotein(a) Is Associated With Increased Risk of Abdominal Aortic Aneurysm [0.03%]
脂蛋白(a)与腹主动脉瘤风险增加有关
Pranav Sharma,Renae Judy,Shuai Yuan et al.
Pranav Sharma et al.
Lp(a) is a genetically determined lipoprotein targeted by emerging therapies. In a UK Biobank analysis (1,026 abdominal aortic aneurysm [AAA] cases, 469,989 controls), elevated Lp(a) was associated with increased risk of AAA, including at c...
Interorganellar Ca2+ Flux Assessment by Flow Cytometry Reveals an Altered Mitochondrial Ca2+ Homeostasis in Circulating Lymphocytes of STEMI Patients [0.03%]
流动式细胞仪评估器官间Ca2+通量显示STEMI患者循环淋巴细胞中线粒体Ca2+稳态改变
Camille Brun,Juliette Geoffray,Florentin Moulin et al.
Camille Brun et al.
Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions [0.03%]
斑珠蛋白-2和桥粒的功能维持能量代谢
J Alex Aycinena,Anley E Tefera,Isaac Perea-Gil et al.
J Alex Aycinena et al.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Alterations in the desmosome gene plakophilin-2 (PKP2) lead to compr...