RIG-I-Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction [0.03%]
RIG-I佐剂增强免疫原诱导T细胞介导的免疫反应控制南美锥虫、查加斯病性心肌炎和左心室功能障碍
Nandadeva Lokugamage,Allison Wyrick,Subhadip Choudhuri et al.
Nandadeva Lokugamage et al.
BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication an...
Matthias Nahrendorf
Matthias Nahrendorf
Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases [0.03%]
孟德尔随机化研究提示血糖特征与胸主动脉结构和疾病存在因果关系
Nimrat Grewal,John Elefteriades
Nimrat Grewal
Matthias Nahrendorf,Kevin King
Matthias Nahrendorf
Edecio Cunha-Neto,Daniela Santoro Rosa
Edecio Cunha-Neto
Fernando Souza-Neto,Preston Le,Mobeen Abdrabbo et al.
Fernando Souza-Neto et al.
Heart failure is a syndrome where immune cells play a crucial role in its development and progression. Although the recruitment of T cells driven by C-X-C motif chemokine receptor 3 activation has been reported, the specific contribution of...
T Cell Polarization in Heart Failure: Any Flavor, as Long as It Is Th1 [0.03%]
心力衰竭中的T细胞极化：任何口味，只要它是Th1型
Marinos Kallikourdis
Marinos Kallikourdis
REPLY: Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases [0.03%]
回复：孟德尔随机化研究提示血糖特征与升主动脉结构和疾病具有因果关系
Tselmen Daria,Justin B Echouffo-Tcheugui,Catherine Tcheandjieu
Tselmen Daria
Laura I Yousif,Aukje G Sijtema,Ymke Appels et al.
Laura I Yousif et al.
Immune checkpoint inhibitor (ICI)-mediated myocarditis is a notorious complication of cancer treatment; however, the role of immune checkpoints in the heart during inflammation remains unknown. We investigated myocardial expression of progr...
JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes [0.03%]
JPN和JCN的相互作用通过破坏肌肉RIN介导的JCN泛素化及其降解来抑制心肌细胞中JCN的作用
Xiaoyun Ji,Yifan Huang,Jinxi Wang et al.
Xiaoyun Ji et al.
Junctophilin-2 (JP2) and junctin (JCN) are key proteins in maintaining calcium homeostasis in cardiomyocytes. Both are reduced in diseased hearts while overexpression of JP2 mitigates heart failure. This study demonstrates that JP2 and JCN ...