Rheumatic Heart Disease: Inflammation, Immune Pathways, Valve Remodeling, and the Promise of SGLT2 Inhibitors [0.03%]
风湿性心脏病：炎症、免疫途径、瓣膜重塑和SGLT2抑制剂的前景
Trung Anh Mai,Benjamin Marchandot,Sandy Hmadeh et al.
Trung Anh Mai et al.
Rheumatic heart disease (RHD) remains the leading cause of acquired valvular heart disease in low- and middle-income countries, affecting an estimated 40 million individuals and disproportionately affecting children and young adults in ende...
TLR7 Inhibition Limits Ischemic Cardiac Injury by Disrupting ITGAM-Dependent Immune-Endothelial Interactions [0.03%]
TLR7抑制通过破坏ITGAM依赖性免疫-内皮细胞相互作用限制缺血性心脏损伤
Yijia Li,Yang Yang,Chanhee Park et al.
Yijia Li et al.
Percutaneous coronary intervention, such as stenting, restores coronary perfusion after myocardial ischemia but also induces ischemia-reperfusion (I/R) injury, in part driven by innate immune activation. Here, we identified Toll-like recept...
Moving Upstream: CD14 Inhibition in Acute Decompensated Heart Failure [0.03%]
溯流而上：心力衰竭急性加重期CD14抑制疗法
Marco Giuseppe Del Buono
Marco Giuseppe Del Buono
Endothelial Cells at the Crossroad of Atherosclerosis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Unifying Target for Dual Treatment [0.03%]
处于动脉粥样硬化和代谢功能障碍相关性肝脂肪变性疾病十字路口的内皮细胞：双重治疗的统一靶点
Cyrine Ben Dhaou,Oren Rom,A Wayne Orr
Cyrine Ben Dhaou
Atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD) are 2 highly prevalent conditions that frequently coexist and amplify each other's clinical burden. MASLD not only increases cardiovascular disease inciden...
Calcitriol Suppresses Platelet Activation and Thrombosis, Mitigating Cardiovascular Risks in Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
骨化三醇可通过抑制代谢功能障碍相关肝脂毒症并由此介导的血小板活化和血栓形成，降低心血管风险
Peng Zhang,Huajie Xu,Shujing Wu et al.
Peng Zhang et al.
Metabolic dysfunction-associated steatotic liver disease is associated with vitamin D deficiency, and platelets exhibit hyperactivity. Zhang et al provide novel insights into the mechanisms underlying platelet hyperreactivity and thrombotic...
Biomechanical Determinants of Plaque Erosion: Translational Implications and Precision Care [0.03%]
斑块侵蚀的生物力学决定因素：转化医学含义及精准治疗
Jason Sangha,Eirinaios Tsiartas,Yuan Huang et al.
Jason Sangha et al.
Plaque erosion is a major cause of acute coronary syndromes and is characterized by endothelial denudation, fibrous-cap integrity, and platelet-rich thrombosis. Advances in intracoronary optical coherence tomography have enabled in vivo ide...
Maria Lembo
Maria Lembo
James Rhee,Haobo Li
James Rhee
Atibuclimab (IC14) for Treatment of Acute Decompensated Heart Failure: A Phase Ib Pilot Study [0.03%]
艾特布昔单抗（IC14）治疗急性心衰失代偿期一期b阶段 pilot研究
Antonio Abbate,Michele Golino,Austin C Hogwood et al.
Antonio Abbate et al.
Systemic inflammation contributes to acute decompensated heart failure. Atibuclimab (IC14) is a monoclonal antibody blocking CD14, an inflammatory mediator associated with adverse cardiovascular outcomes. In this phase Ib, open-label, singl...
A Preventable Congenital Heart Malformation Syndrome Caused by a Mutation in the Glycolytic Gene PFKP [0.03%]
PFKP糖酵解基因突变所致的一种可以预防的先天性心脏病综合征
Siyao Zhang,Hairui Sun,Xu Zhi et al.
Siyao Zhang et al.
This study reports a congenital heart disease, characterized by ventricular wall thinning and septal defects, caused by a heterozygous missense mutation (R755 W) in the glycolytic gene PFKP (platelet isoform of phosphofructokinase-1). The p...