Red Blood Cell-Derived Sealant Repair for Damaged Endothelia Jams Microvasculature in Ischemia and COVID-19 Infection [0.03%]
缺血和COVID-19感染中红细胞衍生的封孔修复阻碍微血管血液循环
Matthias Nahrendorf
Matthias Nahrendorf
OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration [0.03%]
OPA1缺陷损害NGF信号并导致交感神经退行性变
Marco Ronfini,Valentina Prando,Vittoria Di Mauro et al.
Marco Ronfini et al.
Peripheral sympathetic neurodegeneration drives cardiac dysfunction in dominant optic atrophy, revealing a critical neuro-cardiac link. Optic atrophy factor-1 haploinsufficiency disrupts mitochondrial dynamics and neurotrophic signaling, ca...
Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy [0.03%]
儿童心肌病舒张功能障碍的脂质信号异常特征
Andrei L Turinsky,Nour Hanafi,Abdelrahman Said et al.
Andrei L Turinsky et al.
Pediatric cardiomyopathy is a major cause of diastolic heart failure; yet, its mechanisms remain unclear. Global myocardial transcriptomic and blood lipidomic profiling revealed a distinct metabolic signature of diastolic dysfunction marked...
HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells [0.03%]
高密度脂蛋白调节TGFβ受体脂筏分布，恢复胆固醇负荷血管平滑肌细胞的收缩表型
Prashanth Thevkar Nagesh,Shruti Rawal,Hitoo Nishi et al.
Prashanth Thevkar Nagesh et al.
Many cells identified as macrophage-like in human and mouse atherosclerotic plaques are thought to be of vascular smooth muscle cell (VSMC) origin. We identified cholesterol-mediated down-regulation of TGFβ signaling in vitro in human (h)V...
Shaan Khurshid,Samuel Friedman,Rakesh Rathod et al.
Shaan Khurshid et al.
Immune Unresponsiveness to Cardiopulmonary Bypass Is Associated With Unfavorable Outcome in Infants Requiring Cardiac Surgery [0.03%]
体外循环免疫无反应性与心脏手术婴儿不良预后相关
Alexis Chenouard,Mélanie Petrier,Constance Bridonneau et al.
Alexis Chenouard et al.
Cardiopulmonary bypass (CPB) induces a complex immune response which can lead to complications after pediatric cardiac surgery. We hypothesized that analyzing the whole blood transcriptomic response after cardiac surgery with or without CPB...
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers? [0.03%]
冠状动脉组织工程中的模型选择和解释：问题多于答案？
Maximilian Y Emmert,Melanie Generali,Simon P Hoerstrup et al.
Maximilian Y Emmert et al.
Animal Models in Biomedical Research: Realities, Misconceptions, and Controversies [0.03%]
生物医药研究中的动物模型：现实、误解与争议
Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
From early experimental physiology to modern mouse genetics, animal models have been central to the advancement of biomedical knowledge, enabling mechanistic insights into human disease and driving the development of transformative therapie...
Matthias Nahrendorf
Matthias Nahrendorf
Reply: Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers [0.03%]
关于冠状动脉组织工程中的模型选择与解读：仍有待解答的问题多于已知的答案回复信
Kevin M Nash,Robert D Kirkton,Laura E Niklason et al.
Kevin M Nash et al.