Bioelectrical Impedance in Cardiovascular Health: Technologies, Clinical Applications, and Future Directions [0.03%]
心血管健康下的生物阻抗技术、临床应用及未来方向
Suraj Baloda,Benjamin Bouyer,Rémi Dubois et al.
Suraj Baloda et al.
Bioelectrical impedance (BI) is gaining significant attention for its potential in cardiovascular health monitoring and early disease detection. On the basis of the principles of tissue conductivity and body composition, BI operates by appl...
Matthias Nahrendorf
Matthias Nahrendorf
Katharina J Ermer,Vasco Sequeira
Katharina J Ermer
From Viral Trafficking to Immune Surveillance: Does the Heart Harbor an Immune Landing Pad? [0.03%]
从病毒运输到免疫监视：心脏是免疫细胞驻留的场所吗？
Matthias Nahrendorf,Filip K Swirski
Matthias Nahrendorf
Simon Vanhentenrijk,Silvio Nunes Augusto Jr,Jennifer Wilcox et al.
Simon Vanhentenrijk et al.
Myocardial autoimmune responses result in distinctive cardiac diseases and are associated with poor clinical outcomes. Autoantibodies (AAbs) play a crucial role in myocardial humoral autoimmunity by targeting endogenous tissue, or "self-ant...
IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis [0.03%]
白细胞介素-1激活的炎症性心肌纤维母细胞加重急性柯萨奇病毒B3心肌炎
David S Elias,Wonyoung Jo,Monica V Talor et al.
David S Elias et al.
We investigated how inflammatory fibroblasts (IFs) contribute to acute viral myocarditis, a dangerous inflammatory heart disease often caused by infections like coxsackievirus B3 (CVB3). Using CCL2-mCherry reporter mice, we tracked IF kinet...
Nanoparticle Biofunctionalization of Bioprosthetic Heart Valves to Modulate Mechanisms of Structural Valve Deterioration [0.03%]
纳米颗粒生物功能化生物心脏瓣膜以调节结构瓣膜退化的机制
Angus J Grant,Alex H P Chan,Xueying S Xu et al.
Angus J Grant et al.
Bioprosthetic heart valves made from glutaraldehyde-fixed animal pericardium are widely used for valve replacement but are prone to early degeneration arising from the interplay of thrombosis, inflammation, and calcification. Current chemic...
Disrupted Mitochondrial Quality Control in Atherosclerotic Disease: Mitophagy and Dynamics in Focus [0.03%]
动脉粥样硬化疾病中的线粒体质量控制紊乱：以自噬和动力表现为焦点
Taylor Wilcox,Julie Hansen,Andrew Blanker et al.
Taylor Wilcox et al.
Mitochondrial health is essential for maintaining cardiac function, and mitophagy-the selective degradation of damaged mitochondria-is central to maintenance of mitochondrial quality. In this review, we focus on the role of mitophagy in ath...
The Orally Available Ghrelin Receptor-Agonist AC01 Improves Systolic Function in HFrEF Mice and Nonhuman Primates [0.03%]
口服有效胃泌素受体激动剂AC01改善HFrEF小鼠和非人灵长类动物的收缩功能
Lars H Lund,Camilla Hage,Mattias Carlström et al.
Lars H Lund et al.
Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired cardiac contractility. AC01, a small-molecule ghrelin receptor agonist, enhances contractility in cardiomyocytes. This study evaluated the in vivo hemodynamic...
Proteomic Signatures of High-Risk Coronary Plaque Features and Incident Events [0.03%]
易损冠状动脉斑块特征和事件的蛋白质组标志物研究
Anish Karpurapu,Lydia Coulter Kwee,Caroline de Calvacamp et al.
Anish Karpurapu et al.
Patients with and without obstructive coronary artery disease (oCAD) experience heterogeneous cardiovascular risk, and coronary computed tomography angiography (CCTA) high-risk plaque features are not universally available. This study evalu...