Metabolic Reprogramming of Fibroblasts by Extracellular Vesicles: A Therapeutic Axis in Fibrosis [0.03%]
细胞外囊泡介导的纤维化治疗轴：成纤维细胞代谢重编程
Yu Tian,Andrew A Gibb
Yu Tian
Yixiao Zhu,Li Lin,Xiaoxia Wei
Yixiao Zhu
Shaun Khanna,Nitesh Nerlekar,Aditya Bhat
Shaun Khanna
Conventional models frame obesity as excess caloric intake but do not explain why cardiometabolic disease develops in only a subset of individuals. Building on Unger's seminal lipotoxicity hypothesis and subsequent adipose expandability fra...
Pillars of Peer Review [0.03%]
同行评审的支柱
Matthias Nahrendorf
Matthias Nahrendorf
Barry London
Barry London
Inhibition of Cyclophilin D Rescues Cardiac Function and Bioenergetic Defects Caused by Neonatal Hypoxia [0.03%]
环磷肽D抑制剂可治疗新生儿缺氧引起的心功能和生物能量代谢缺陷
Jonathan R Burris,Gisela Beutner,Min Yee et al.
Jonathan R Burris et al.
Increased oxygen levels at birth regulate myocyte bioenergetic and structural maturation controlled by mitochondrial cyclophilin D (CypD). We evaluated mechanisms of neonatal hypoxic cardiac dysfunction by exposing neonatal mice to 12% oxyg...
Targeting Senescence in Adipose Microvasculature: A New Target Diabetes and Heart Failure [0.03%]
靶向脂肪微血管衰老：糖尿病和心力衰竭的新靶点
Mallikarjun Patil,Daniel J Tyrrell
Mallikarjun Patil
Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome [0.03%]
系统地破坏斑马鱼的弹性蛋白基因，发现了一个翻译模型揭示马方综合征的机制
Karo De Rycke,Marina Horvat,Lisa Caboor et al.
Karo De Rycke et al.
Fibrillin defects lead to severe cardiovascular complications in Marfan syndrome (MFS), including aortic dilation, dissection, and rupture. To model MFS, zebrafish mutants lacking various fibrillin genes were generated. Among these mutant l...
Exercise Reverses Mental Stress-Induced Vascular Inflammation and Builds Stress Resilience [0.03%]
运动逆转心理压力引起的血管炎症并增强压力抵抗力
Ulrike Meyer-Lindemann,Karina Borbil,Marius Schwab et al.
Ulrike Meyer-Lindemann et al.
Mental stress is a major risk factor for cardiovascular disease, yet no targeted therapies exist to reduce stress-related vascular risk. We investigated whether physical activity mitigates the adverse cardiovascular effects of acute mental ...
Pauline Mury,Olina Dagher,Pierre-Emmanuel Noly et al.
Pauline Mury et al.
Left ventricular assist devices remain a major step forward for end-stage heart failure patients awaiting transplantation. We investigated the molecular basis of the longitudinal effect of left ventricular assist device implantation in both...