M Imran Aslam,Aleksandra B Gruslova,Luis A Diaz Sanmartin et al.
M Imran Aslam et al.
An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative he...
Precision Medicine: Therapeutically Targeting Mitochondrial Alterations in Heart Failure [0.03%]
精准医疗：治疗靶向心力衰竭中的线粒体异常
Alex M Parker,Jarmon G Lees,Andrew J Murray et al.
Alex M Parker et al.
A substantial component of the increasing global burden of cardiovascular disease is attributed to heart failure (HF), affecting over 64 million adults worldwide. Maladaptive mitochondrial respiratory alterations and oxidative stress are ma...
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells [0.03%]
高甘油三酯血症患者的T细胞转录组特征与心血管风险评估中的血脂和T细胞标志物关系研究
Nathalie A Reilly,Janneke W C M Mulder,Koen F Dekkers et al.
Nathalie A Reilly et al.
Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atheroscleroti...
Therapeutic Implications of ErbB Pathway Modification in Heart Failure with Reduced Ejection Fraction [0.03%]
射血分数降低的心力衰竭中ErbB通路改变的治疗意义
Senthil Selvaraj,G Michael Felker
Senthil Selvaraj
Double-Edged Signaling: FAK's Role in Aortic Dissection Progression [0.03%]
双刃剑式的信号转导：FAK在主动脉夹层进展中的作用
Neha E H Dinesh,Dieter P Reinhardt
Neha E H Dinesh
Plasma-Derived Extracellular Vesicle-Propagated microRNA From Aortic Stenosis Patients Render Pro-Calcifying Effects on Valve Interstitial Cells [0.03%]
主动脉瓣狭窄患者血浆外泌体衍生的微小RNA促进瓣膜间质细胞钙化作用
Avinash B Khandagale,Padraic Corcoran,Yuzhen Dan et al.
Avinash B Khandagale et al.
Extracellular vesicles (EVs) and microRNAs (miRs) have been found to be differently expressed in patients with aortic valve stenosis (AS). Here, we profiled the expression of miRs associated with circulating EVs from severe AS patients and ...
Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF [0.03%]
集成系统生物学识别出线粒体功能和代谢紊乱是HFpEF的关键促成因素
Andrew A Gibb,Kyle LaPenna,Ryan B Gaspar et al.
Andrew A Gibb et al.
Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases. The ZSF1-obese rat model recapitulates clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and diastoli...
Preclinical Efficacy of a Hemostatic Agent in Overcoming Dual Antiplatelet Therapy [0.03%]
一种止血剂克服双通道抗血小板药物治疗的临床前有效性研究
Evgeni Efimenko,Hairu Zhao,Keith Moskowitz et al.
Evgeni Efimenko et al.
This preclinical evaluation of a prohemostatic agent involved patients who received aspirin and clopidogrel before coronary artery stenting, the use of a humanized animal model to assess the hemostatic properties of patient platelets, as we...
Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension [0.03%]
微生物移植治疗肺动脉高压安全可行
Daphne Moutsoglou,Madelyn Blake,Dina C Belhasan et al.
Daphne Moutsoglou et al.
Pulmonary arterial hypertension (PAH) is a complex inflammatory disease that the gut microbiome likely contributes to and may be a potential therapeutic avenue for nontoxically improving outcomes. Here, we show that microbiota transplant th...
Cracking the Code of a Preclinical Rodent Model of HFpEF: The Mitochondrial Link [0.03%]
破解HFpEF前期啮齿动物模型密码：线粒体连接点
Chae-Myeong Ha,Adam R Wende
Chae-Myeong Ha