SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease [0.03%]
SECTM1通过调节单核细胞水平影响冠心病发病风险
Usman A Tahir,Daniel Cruz,Dongxiao Shen et al.
Usman A Tahir et al.
Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SE...
Minimally Invasive Aortic Regurgitation Surgery: A Mouse Model of Volume Overload-Induced Cardiac Remodeling by Aortic Regurgitation [0.03%]
微创主动脉瓣反流手术：由主动脉瓣反流引起的心脏重塑的体积过载小鼠模型
Jinyun Zhu,Chen Gao,Yibin Wang
Jinyun Zhu
A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice [0.03%]
一种小鼠微创主动脉瓣反流手术诱导的心肌重构的新模型
Xiang Li,Jian Wu,Le Kang et al.
Xiang Li et al.
Although the prevalence of aortic regurgitation (AR), which causes eccentric remodeling and valvular heart disease (VHD), is increasing, suitable animal research models remain lacking. To address this issue, we established the first efficie...
Adam R Williams,Kevin M Nash,Robert D Kirkton et al.
Adam R Williams et al.
Coronary artery bypass graft (CABG) uses the patient's internal mammary artery and saphenous vein; however, unavailable or poor quality autologous vessels limit revascularization. This study addresses the critical need for alternative CABG ...
Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy [0.03%]
整合转录组-组织学分析揭示Diltiazem通过抑制FGFR1发挥抗心肌纤维化和心脏保护作用用于扩张型心肌病治疗
Reo Hata,Shunsuke Funakoshi,Takeru Makiyama et al.
Reo Hata et al.
Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM b...
Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure [0.03%]
靶向长链非编码RNA SMILR的小干扰RNA疗法可干预冠状动脉旁路移植失败
Simon D Brown,Anna L Malinowska,Matthew Bennett et al.
Simon D Brown et al.
Coronary artery bypass graft (CABG) surgery remains the gold standard of care to prevent myocardial ischemia in patients with advanced atherosclerosis; however, poor long-term graft patency remains a considerable and long-standing problem. ...
Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics [0.03%]
新型肽类疗法通过降低线粒体能量生成来靶向L型钙通道以防止肥厚性心肌病
Teagan S Er,Daniel Reinke,Alice J Francis et al.
Teagan S Er et al.
Mitochondrial dysfunction is considered to drive the development of hypertrophic cardiomyopathy (HCM). In search of a preventative HCM therapy, we explored the efficacy of amino acid peptide variants that could alter the L-type Ca2+ channel...
Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension [0.03%]
次黄嘌呤促进肺血管重塑及腺苷脱氨酶是肺动脉高压的治疗靶点
Jun-Zhuo Shi,Yong-Jian Zhu,Meng-Jie Zhang et al.
Jun-Zhuo Shi et al.
Uric acid metabolism is implicated in the pathogenesis of pulmonary arterial hypertension, wherein the key metabolite hypoxanthine exhibits elevated levels, thereby promoting pulmonary vascular remodeling through facilitation of cell prolif...
Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction [0.03%]
心脏TRPM7导致射血分数保留的心力衰竭糖尿病并发症
Man Liu,Hong Liu,Gyeoung-Jin Kang et al.
Man Liu et al.
Hypomagnesemia (HypoMg) and subsequent oxidative stress cause diabetic cardiac diastolic dysfunction and heart failure with preserved ejection fraction. A Mg2+ transporter with channel and kinase function, transient receptor potential catio...
Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA: Novel Insight Into the Mechanism of Plaque Erosion [0.03%]
尼古丁促进EC线粒体依赖性细胞焦亡的机制及对动脉粥样硬化斑块稳定性的影响研究
Xing Luo,Ji Li,Yuwu Chen et al.
Xing Luo et al.
Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E-/- mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth...