Polysaccharide-engineered mitochondria reprogram macrophages to resolve diabetic wound inflammation and promote repair [0.03%]
多糖工程线粒体重构巨噬细胞缓解糖尿病伤口炎症和促进修复
Chenyan Yu,Qian Feng,Yuheng Liao et al.
Chenyan Yu et al.
Chronic diabetic wounds are characterized by persistent inflammation, defective resolution and impaired tissue regeneration, in which macrophage dysfunction and mitochondrial damage play central roles. Here, we developed a macrophage-target...
Revolutionizing Mg-based guided bone regeneration mesh derived from endogenous dentoalveolar bone augmentation [0.03%]
革命性镁基引导骨再生网板来源于牙槽植骨的内源性材料
Shiyuan Li,Mingyu You,Hao Zheng et al.
Shiyuan Li et al.
Ideal regeneration of alveolar bone remains challenging due to its irregular morphology, complex structure, and unique biological functions. Advances in computer-aided design (CAD) and additive manufacturing (AM) have facilitated the develo...
Robust and durable zwitterionic hydrogel coating with catechol-Cu2+ coordination for antithrombotic and antibacterial blood-contacting devices [0.03%]
用于血液接触型医疗器材的抗凝血及抗菌卡 tell-Cu2+ 配位两性离子水凝胶涂层
Guanghang Bai,Yuxin Xie,Ying Sun et al.
Guanghang Bai et al.
Thrombosis and bacterial infection remain two major life-threatening complications associated with blood-contacting medical devices. Although zwitterionic hydrogel coatings mitigate these risks by forming strongly hydrated interfaces that r...
Lucia Aboal-Castro,Vasiliki K Kolliopoulos,Carmen Alvarez-Lorenzo et al.
Lucia Aboal-Castro et al.
The osteochondral unit has a complex hierarchical structure where cartilage and subchondral bone show different physical, chemical, and functional properties. Replicating this structure remains a major challenge in osteochondral tissue engi...
Spatiotemporally reprogrammed L-arginine metabolic nanoregulator potentiates immunotherapy [0.03%]
时空编程的L-精氨酸代谢纳米调节剂可增强免疫治疗功效
Qian Cheng,Xiaolei Shi,Qushuhua Qin et al.
Qian Cheng et al.
L-arginine (L-Arg) deprivation in the tumor microenvironment (TME) drives effector T cell dysfunction and immunotherapy resistance. However, simply supplementing L-Arg can be counterproductive, as tumor cells and immunosuppressive myeloid c...
Robust loading and delivery of functional small RNAs via protein N-myristoylation-induced small extracellular vesicles [0.03%]
基于蛋白质N-我里斯托伊酰化诱导的小细胞外囊泡的功能性小RNA的稳定负载和高效递送
Huijie Wang,Xiaozhe Zhang,Yunjun Liang et al.
Huijie Wang et al.
Small extracellular vesicles (sEVs) are naturally secreted nanovesicles that mediate intercellular communication by transporting biomolecules such as proteins and nucleic acids. Their inherent biocompatibility makes them promising platforms...
Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response [0.03%]
二甲双胍通过NRF2介导的IRE1α依赖性未折叠蛋白反应恢复缓解与衰老相关的牙周炎
Yu Sun,Qifeng Chen,Yan Zhao et al.
Yu Sun et al.
Proteostasis disruption due to impaired unfolded protein response (UPR) is a hallmark of aging and contributes largely to cellular dysfunction, but its role and associated mechanisms in aging-associated periodontitis remain unclear. This st...
Intelligent microneedle patch with cobalt-iron Prussian blue nanozymes for accelerating diabetic wound healing via heme biosynthesis-driven immunomodulation [0.03%]
一种智能微针贴片通过血红素生物合成驱动免疫调节加速糖尿病伤口愈合
Yutong Zhu,Yichen Kuang,Runjie Miao et al.
Yutong Zhu et al.
A complex wound microenvironment with the presence of bacterial infection, overproduction of hydrogen peroxide (H2O2), chronic inflammation, poor vascularization and hypoxia wound result in delayed healing of diabetic wounds. In this study,...
A bioactive magnesium alloy scaffold integrated with BMSCs-Loaded 3D microspheres synergistically promotes femoral head osteonecrosis repair by improving the osteogenic-angiogenic microenvironment [0.03%]
负载间充质干细胞的3D微球生物活性镁合金支架协同改善股骨头坏死的成骨和血管化微环境修复研究
Minzheng Guo,Haojing Xu,Zijie Pei et al.
Minzheng Guo et al.
Osteonecrosis of the Femoral Head (ONFH) is primarily characterized by impaired osteogenesis and insufficient vascularization, leading to progressive structural collapse and limb dysfunction. To develop a targeted strategy for regulating th...
A full-active phosphorus dendron-based nanomedicine alleviates ischemic stroke through multi-target immunomodulation and neuroprotection [0.03%]
一种全激活的磷树状高分子纳米医药通过多靶点免疫调节和神经保护缓解缺血性脑卒中
Caiyun Zhang,Huxiao Sun,Yu Zou et al.
Caiyun Zhang et al.
Designing nanomedicines with full-active components to overcome the blood-brain barrier (BBB) and achieve multi-target immunomodulation and neuroprotection for effective ischemic stroke (IS) treatment still remains a great challenge. Herein...