Mn3O4-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis [0.03%]
用于温和温控肿瘤消融和骨生成的Mn3O4增强型双功能水凝胶
Yao Zhao,Wenkai Wang,Mingyi Liu et al.
Yao Zhao et al.
Postoperative bone reconstruction after tumor resection remains challenging due to tumor recurrence and poor osteogenesis. Although photothermal scaffolds can ablate tumors (via high heat) and stimulate bone formation (via mild heat), balan...
Advancements in dual-targeting nanoparticle strategies for enhanced atherosclerosis therapy: Overcoming limitations of single-targeting approaches [0.03%]
双重靶向纳米颗粒策略在改善动脉粥样硬化治疗中的进展：克服单次靶向方法的局限性
Can Yang,Liqing Mo,Guizhi Zhang et al.
Can Yang et al.
Atherosclerosis treatment remains challenging, particularly in terms of developing effective targeted drug delivery strategies to enhance therapeutic efficacy. As research advances, considerable attention has been paid to identifying specif...
Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics [0.03%]
响应性纳米医学策略实现胰腺癌精准诊疗
Fangjian Li,Zixiang Tang,Yating Zheng et al.
Fangjian Li et al.
Pancreatic ductal adenocarcinoma (PDAC), the predominant subtype of pancreatic cancer, ranks among the deadliest malignancies worldwide, with a 5-year survival rate remaining below 13 %. Its poor prognosis stems from complex anatomical barr...
Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment [0.03%]
用于牙周炎治疗的温敏型抗菌纳米复合水凝胶引导巨噬细胞极化及骨再生
Xiang Yu,Huiling Liu,Lingdi Chen et al.
Xiang Yu et al.
Periodontitis is a chronic inflammatory disease caused by bacterial infection that leads to the destruction of periodontal tissues. Traditional treatment involves scaling and root planing combined with antibiotics, but systemic antibiotic t...
Synergistic fusion of CD47, VE-cadherin and mussel adhesion protein promotes endothelialization and suppresses inflammation in vascular stents [0.03%]
融合CD47、VE-钙粘蛋白和贻贝黏附蛋白促进血管内植入物内皮化及抑制炎症响应的新策略
Wenhua Yan,Shuyu Li,Tian Zhang et al.
Wenhua Yan et al.
Endothelial cell (EC)-specific coatings for vascular stents are crucial for enhancing their biocompatibility and preventing complications such as restenosis and thrombosis. This study developed an innovative CD47-VE-cadherin-Mfp5 (CD47-VE-M...
Shuyin Zhou,Lijun Cai,Yi Cheng et al.
Shuyin Zhou et al.
Nanomotors have come to the forefront as a powerful tool for thrombolysis. Attempts in this field tend to improve the structure and function of nanomotors for safe and efficient treatment. To address the problem of low utilization and high ...
Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death [0.03%]
超声波触发的纳米西德诺米星协同ROS生成和类似铁死亡作用杀灭细菌生物被膜感染
Xin Pang,Chang Zhang,Qicai Xiao et al.
Xin Pang et al.
Biofilm formation poses a severe challenge to antibacterial stewardship. While siderophore-antibiotic conjugates (termed as sideromycins) offer a promising solution, their efficacy is inherently limited by antibiotic resistance. To transcen...
3D-printed functionalized strontium-silk fibroin-hydroxyapatite scaffolds facilitate bone regeneration via immunomodulatory and sequential angiogenic-osteogenic coupling [0.03%]
基于Sr的功能化丝素/羟基磷灰石的3D打印支架通过免疫调节和血管生成-成骨偶联促进骨骼再生
Kui Huang,Qilin Li,Yunfei Liu et al.
Kui Huang et al.
The repair of large bone defects remains a significant clinical challenge. The development of bioactive materials for bone tissue engineering offers promising solutions to address these problems. However, the lack of vascularization and the...
Mesenchymal stem cell-laden double-network hydrogel nerve guidance conduits for peripheral nerve injury repair [0.03%]
负载间充质干细胞的双网络水凝胶神经导管修复周围神经损伤
Junghyun Kim,Junggeon Park,Seungjun Lee et al.
Junghyun Kim et al.
To enhance the repair of peripheral nerve injuries (PNIs), various nerve guidance conduits (NGCs) have been developed by integrating topological, biochemical, and cellular cues. Hydrogel-based NGCs are particularly promising owing to their ...
Remodeling of senescent macrophages in synovium alleviates trauma- and aging-induced osteoarthritis [0.03%]
关节滑膜衰老巨噬细胞重塑可缓解创伤和年龄相关的骨关节炎病理进展
Yuhang Liu,Jianan Duan,Yifan Dang et al.
Yuhang Liu et al.
Osteoarthritis (OA) is one of the most concerned aging-related diseases in the worldwide, yet the investigation of immune senescence in joint and related therapies are still poorly identified. Single-cell sequencing analysis and immunofluor...