BMP-7 mRNA delivered by Fibrin-CaP scaffolds activates osteogenic programs in vivo as evidenced by transcriptomic and proteomic analyses [0.03%]
基于纤维蛋白-CaP支架递送的BMP-7 mRNA通过转录组学和蛋白质组学分析激活体内成骨程序
Claudia Del Toro Runzer,Nadia Roumans,Freek G Bouwman et al.
Claudia Del Toro Runzer et al.
Two recombinant bone morphogenetic proteins (BMP-2 and BMP-7) have received FDA approval for bone-related therapies. However, their clinical performance is limited by high costs, the need for supraphysiological doses, and adverse side effec...
A nucleic acid regulation strategy under mechanical stress for intervertebral disc degeneration treatment [0.03%]
一种机械应力下核酸调控策略用于椎间盘退变治疗
Wenchao Wang,Wenxiang Huo,Dingfei Qian et al.
Wenchao Wang et al.
The nucleus pulposus (NP), the core shock-absorbing component of the intervertebral disc (IVD), plays a vital role in the pathogenesis of intervertebral disc degeneration (IVDD). Here, we uncover that degenerative NP tissue under mechanical...
Mechanically preconditioned stem cells therapy using bioinspired liver-mimetic microspheres for functional liver repair [0.03%]
一种用于功能性肝修复的生物启发型肝脏仿生微球机械预处理干细胞疗法
Tiantian Xue,Jiabin Zhang,Bin Wang et al.
Tiantian Xue et al.
Hepatocyte-like cells (HLCs) represent a promising therapeutic approach for acute liver failure (ALF), offering an alternative to primary hepatocytes, which are in short supply. Given the viscoelastic tissue properties of the liver and the ...
The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration [0.03%]
骨稳态和再生的力学-免疫-囊泡调控回路：一种系统框架
Ting Yang,Zhili Dong,Lili Chen et al.
Ting Yang et al.
Bone remodeling is a mechanically adaptive process that integrates physical loading with immune regulation during homeostasis, repair, and disease. However, the traditional view fails to fully explain how mechanical and immune signals are c...
Lyophilized bacteria-infected tumor cells for targeted immunotherapy of lung metastases and associated fibrosis [0.03%]
冷冻干燥的感染细菌瘤细胞针对肺癌转移及相关的纤维化免疫治疗
Mo Chen,Yueyang Deng,Tianxu Fang et al.
Mo Chen et al.
Lung metastasis remains a major clinical challenge, often associated with poor prognosis due to its highly immunosuppressive microenvironment and fibrosis-induced complications. Current treatment strategies, including chemotherapy, radiothe...
Engineered protein nanoclusters reduce liver fibrosis and hepatocellular carcinoma in mice models [0.03%]
工程化蛋白质纳米簇可减少小鼠肝纤维化及肝细胞癌
Tanya Saxena,Gabriela Guedes,Inês Domingues et al.
Tanya Saxena et al.
Long-term liver injury leads to acute hepatitis and chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), which frequently necessitate liver transplantation and are associated with poor median survival. Transforming...
A BAI1-PSTB-Hydrogel promotes diabetic wound healing by targeting mtDNA leakage and the cGAS-STING axis to alleviate endothelial senescence [0.03%]
一种BAI1-PSTB-水凝胶通过靶向线粒体DNA渗漏和cGAS-STING轴来缓解内皮细胞衰老从而促进糖尿病伤口愈合
Xianqi Wang,Rui Zheng,Wenjie Cheng et al.
Xianqi Wang et al.
Background: Diabetic Wound (DW) is one of the most prevalent complications in diabetes patients, impairing patient wellbeing and quality of life severely. The pathogenesis of DW remains incompletely understood, hindering ...
An injectable tough hydrogel sealant enabling rapid hemostasis and promoting oral tissue regeneration [0.03%]
一种可注射的坚韧型水凝胶止血剂实现快速止血并促进口腔组织再生
Jinghan Wang,Gang He,Zheng Pan et al.
Jinghan Wang et al.
Repair of oral soft-tissue injuries remains challenging due to the moist, bacteria-rich, and mechanically active oral environment, as well as the limitations of current sealants in wet adhesion, mechanical strength, biocompatibility, bioact...
A naphthyl polymer with STING-activating property for antigen and adjuvant co-delivery to achieve potent cancer immunotherapy [0.03%]
一种具有STING激活作用的萘基聚合物共递呈抗原和佐剂用于高效癌症免疫治疗
Lanfang Ren,Qianqian Chen,Yan Lou et al.
Lanfang Ren et al.
Therapeutic cancer vaccines remain constrained by insufficient intracellular antigen trafficking and weak activation of innate immunity. Here, we report an immunoactive dendrimer-based nanovaccine platform that integrates efficient antigen ...
A closed-loop myocardial infarction theranostic platform activated by macrophage-derived nitric oxide and acidic microenvironment [0.03%]
一种由巨噬细胞衍生的NO和酸性微环境激活的闭合回路心肌梗死诊疗平台
Xuan Xu,Shengnan Li,Yan Chen et al.
Xuan Xu et al.
Precise management of the inflammatory response after myocardial infarction necessitates targeted engagement of cellular drivers. Here, we report a pathophysiology-guided theranostic platform that exploits two defining features of pro-infla...