Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model [0.03%]
急性青光眼模型下协调调节RGC铁死亡和氧化应激的分层ROS清除水凝胶系统
Hong Ren,Yukun Wu,Yang Yang et al.
Hong Ren et al.
Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying a...
Orally activatable membrane fusion-mitochondria hitchhiking on intestinal macrophages for targeted therapy of bacterial meningitis and neuroinflammation [0.03%]
一种口服激活的膜融合药物递送系统用于治疗细菌性脑膜炎和神经炎症
Xingyou Wang,Xiaoqing Sun,Han Li et al.
Xingyou Wang et al.
Targeting the formidable physiological barriers and neuronal damage refractory to conventional bactericidal agents for bacterial meningitis, we engineered an infection microenvironment-activatable membrane fusion-mitochondrial formulation (...
Stage-aligned electro-ionic biobattery hydrogel for enhanced wound closure and scar reduction [0.03%]
用于增强伤口闭合和减少疤痕的分阶段电离子生物电池水凝胶
Kaiqi Qin,Pengyu Wei,Xinyue Huang et al.
Kaiqi Qin et al.
Coupling electrical stimulation (ES) with biochemical signaling is attractive for coordinating multi-stage wound healing, yet existing biobatteries rarely deliver stable microcurrents with stage-aligned chemical therapy in a scalable format...
Retrievable "sea-island" microstructured zwitterionic-silicone hydrogel devices: augmented oxygen transport and anti-fibrosis for sustaining islet survival [0.03%]
可回收的“海島”微結構雙性離子硅水凝膠器件：增強氧運輸和抗纖維化以維持胰島存活
Danyang Chen,Hongying Wang,Yipeng Tang et al.
Danyang Chen et al.
Islet encapsulation is a transformative strategy for type 1 diabetes (T1D) cellular therapy, enabling islet transplantation without lifelong immunosuppression. However, macroscale encapsulation faces prominent challenges: poor surgical retr...
Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs [0.03%]
类应力颗粒通过补充溶酶体修复来恢复巨噬细胞的免疫代谢抗细菌程序
Shenzhi Zhao,Liang Chen,Zhenxuan Shao et al.
Shenzhi Zhao et al.
Severe intracellular bacterial infection can progressively compromise lysosomal defence in macrophages, yet the underlying repair bottleneck remains unclear. Here we identify a time-dependent exhaustion of stress granule (SG)-associated lys...
Field-ridge structured bioactive Zn-based scaffold promotes bone regeneration via cellular mechanotransduction [0.03%]
场 ridge 结构生物活性锌基支架通过细胞力学信号转导促进骨再生
Xuanhe Feng,Dongxu Xie,Qiunan Zhou et al.
Xuanhe Feng et al.
Large bone defects often exhibit impaired healing due to the absence of a favorable osteoinductive microenvironment at the defect core. Drawing inspiration from agricultural field-ridge structures, we developed a Zn-based metallic biomimeti...
Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants [0.03%]
苯并噻唑衍生物可靶向寡腺苷酸合成酶并作为佐剂增强RSV疫苗效力
Xuanli Jin,Zhihui Zhang,Hong Liu et al.
Xuanli Jin et al.
2',5' oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation o...
Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants [0.03%]
苯并噻唑衍生物靶向寡腺苷酸合成酶可增强呼吸道合胞病毒疫苗效力成为免疫佐剂
Xuanli Jin,Zhihui Zhang,Hong Liu et al.
Xuanli Jin et al.
2',5' oligoadenylate (2-5A) activates RNase L to degrade intracellular RNA and inhibit viral proliferation. The resulting nucleotide fragments bind RIG-I-like receptors to initiate type I interferon (IFN-I) signaling, enhancing maturation o...
Engineering functional vasculatures to reconstruct sympathetic-parasympathetic circuits for bladder function after spinal cord injury [0.03%]
工程化构建血管神经网络，治疗脊髓损伤的膀胱功能障碍
Haiyan Weng,Longyou Xiao,Ting Li et al.
Haiyan Weng et al.
Spinal cord injury (SCI) leads to severe neurogenic bladder dysfunction, and its recovery highly depends on the restoration of bladder innervation of sympathetic-parasympathetic nerves. Stable blood perfusion is a prerequisite for sustainin...
Y-RBCEVs accelerate fracture repair through osteogenesis and VCAN-mediated CD44/PI3K/AKT-dependent macrophage polarization [0.03%]
Y-RBCEVs通过促进成骨和VCAN介导的CD44/PI3K/AKT依赖性巨噬细胞极化来加速骨折修复
Jiahao Wang,Xiaokang Zhang,Qi Zhang et al.
Jiahao Wang et al.
Objective: To investigate the effects of young human red blood cell-derived extracellular vesicles (Y-RBCEVs) on fracture healing. Methods: ...