Silicate biomaterials-based multicellular scaffolds with specific cellular spatial distribution for infarcted myocardium repair [0.03%]
基于硅酸盐生物材料且具有特定空间分布的多细胞支架促进心肌梗死组织修复
Chen Qin,Zhibin Liao,Zhixu Wang et al.
Chen Qin et al.
Constructing artificial myocardial tissue that matches the structure and function of natural myocardium is a promising approach for repairing infarcted myocardium and reconstructing cardiac function. In this study, a biomimetic myocardium s...
Mechanically adaptive Mg-Ti composites guided by single-cell insights accelerate load-bearing bone regeneration via dual modulation of osteogenesis and osteoclastogenesis [0.03%]
单细胞洞察引导的机械适应性镁钛复合材料通过双重调节成骨和破骨促进承重骨再生
Wanxin Zheng,Sirui Tian,Jiaxing Huo et al.
Wanxin Zheng et al.
The regeneration and repair of load-bearing bone defects require a delicate balance between mechanical stability and biological integration. Magnesium (Mg)-based materials are promising due to their bioactivity, but their rapid degradation ...
CAP-CD56+CD271+ BMSCs exos-loaded PVA/SA sustained-release hydrogel attenuates chondrocyte senescence and ameliorates lumbar facet joint osteoarthritis [0.03%]
负载CAP-CD56+CD271+骨髓间充质干细胞外泌体的PVA/SA缓释水凝胶可减轻软骨细胞衰老和改善腰椎小关节骨关节炎
Yong Xie,Quanbo Liu,Jinghua Tan et al.
Yong Xie et al.
Objective: This study aimed to develop a novel, targeted therapy for lumbar facet joint osteoarthritis (LFJ OA) by identifying a potent bone mesenchymal stem cell (BMSC) subpopulation for cartilage regeneration, engineeri...
Programmed PTH pulsatility coupled with piezoelectric stimulation via ultrasound-activated scaffolds synergizes deep bone defect regeneration [0.03%]
基于超声激活支架的程序化PTH脉冲分泌与压电刺激协同促进深部骨缺损再生
Xin Wang,Linyuan Shu,Bohao Yin et al.
Xin Wang et al.
Large bone defects in deep anatomical regions continue to pose significant clinical challenges for osteogenic reconstruction. While pulsatile low-dose parathyroid hormone (PTH) administration shows therapeutic potential for bone regeneratio...
Low addition of Er and Zn into biomedical magnesium with enhanced integrated properties for orthopedic applications: in vitro and in vivo studies [0.03%]
少量添加Er和Zn改善镁合金在体外及体内综合性能的研究
Jianing Liu,Yulin Lin,Ming Wang et al.
Jianing Liu et al.
As the common alloying elements of Mg, rare earth elements (REEs) have been extensively explored due to their prominent effect on melt purification and mechanical strengthening. However, as for orthopedic applications, the only Mg-RE based ...
Magnetic-topological multistage synergy: Anisotropic ovalbumin scaffolds loaded with magnetically-responsive neural cells for long-distance peripheral nerve regeneration [0.03%]
磁-拓扑多级协同作用：用于远距离周围神经再生的各向异性卵清蛋白支架负载磁响应性神经细胞
Wenchao Guan,Yaqiong Liu,Mingzhu Jia et al.
Wenchao Guan et al.
Rapid repair and functional reconstruction of long-distance peripheral nerve injury (PNI) is an important clinical challenge, but existing therapeutic strategies are unable to go beyond autologous nerve grafts to meet the clinical needs. An...
Synergistic phototherapy and Ca2+ consumption for combating biofilms in diabetic wounds via ion interference, physical disruption, and biological regulation [0.03%]
离子干扰、物理破坏和生物调节协同对抗糖尿病伤口生物膜感染
Yangkun Liu,Gongmeiyue Su,Xudong Tan et al.
Yangkun Liu et al.
Multimodal treatment has become an essential strategy for addressing complex diabetic wound biofilm infections, which are resistant to conventional antibiotics and immune responses. Phototherapy including photodynamic therapy (PDT) and phot...
An inhalable gallium-polyphenol nanoparticle blocks bacterial electron transport chain and signal transduction for anti-biofilm therapy [0.03%]
一种可吸入的镓-聚酚纳米颗粒通过阻断生物膜细菌电子传递链和信号转导通路用于防治生物膜感染
Yanwen Ni,Yue Huang,Yongcheng Chen et al.
Yanwen Ni et al.
Bacterial biofilms have become an escalating global health threat due to their persistent infections and antimicrobial resistance. Conventional antibacterial approaches often fail to eliminate biofilms due to biofilm complexity involving bo...
Spatiotemporal evaluation of antithrombotic performance for biomaterials through monitoring β-sheet conformation changes at the blood interface [0.03%]
通过监测血液界面的β折叠构象变化对生物材料的抗凝血性能进行时空评价
Hui Zhou,Yizhou Xu,Shuxiang Zhang et al.
Hui Zhou et al.
Thrombosis remains a critical challenge for blood-contacting medical devices, often resulting in device failure and potentially fatal complications. While various antithrombotic surfaces have been developed, the role of material-induced pro...
A self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium [0.03%]
一种自锁式导电心脏补丁，可使心肌梗死大鼠的心肌组织实现即时电气整合
Mengqi Shan,Yimeng Li,Leqian Wei et al.
Mengqi Shan et al.
Myocardial infarction (MI) is the leading cause of human death. Conductive patches have emerged as a promising alternative for MI repair. However, due to the epicardium and the scar tissue blocking the electrical connection between the patc...