Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration [0.03%]
一种用于骨再生、具有自愈功能的可注射型骨/生物粘合剂移植物输送系统及其工程化方法
Qingzu Liu,Bin Zhu,Huikai Yang et al.
Qingzu Liu et al.
The incidence of open bone defects caused by high kinetic and potential energy injuries has significantly increased. Bone grafting, typically in the form of granules, is widely recognized as the most effective treatment. However, current bo...
Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment [0.03%]
稳定的生物活性水凝胶涂层在硅酮表面通过光化学处理进行非侵入性除污染
Romina Berger,Alina Rahtz,Alexander Schweigerdt et al.
Romina Berger et al.
Polydimethylsiloxane (PDMS) is widely used in biomedical applications due to its biocompatibility, chemical stability, flexibility, and resistance to degradation in physiological environments. However, its intrinsic inertness limits further...
Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing [0.03%]
负载单宁酸的掺锌和铜介孔生物活性玻璃纳米粒子：伤口愈合的潜在抗氧化纳米载体
Sara Pourshahrestani,Irem Unalan,Ehsan Zeimaran et al.
Sara Pourshahrestani et al.
Polyphenols such as tannic acid (TA) with antibacterial and antioxidant activities have recently attracted significant attention for wound healing applications. Mesoporous bioactive glass nanoparticles (MBGNs) have also garnered considerabl...
Li Li,Wenbi Wu,Qi Zhu et al.
Li Li et al.
Bioprinting provides a promising tool to customize human tissues for medicine. Currently, it is expected to generate a tissue from the printed tissue construct that is consisted of biomaterials and cells. One of the major challenges is the ...
Mechanism and regulatory strategy study on promoting vascularized bone regeneration via intracellular zinc ion transport [0.03%]
基于细胞内锌离子转运的血管化骨再生促进机制及调控策略研究
Yitong Liu,Siyan Liu,Juan Du et al.
Yitong Liu et al.
Bone regeneration is a major clinical challenge. The main obstacles to bone injury repair are local blood flow disorders and hypoxic microenvironments. Mesenchymal stem cell (MSC) therapy has notable advantages in promoting bone-tissue rege...
Localised delivery of interleukin-13 from a PLGA microparticle embedded GelMA hydrogel improves functional and histopathological recovery in a mouse contusion spinal cord injury model [0.03%]
负载PLGA微球的GelMA水凝胶局部递送白细胞介素-13改善小鼠脊髓损伤的功能及组织病理学恢复
Ciara M Walsh,Ruth Colbert,James P Reynolds et al.
Ciara M Walsh et al.
Spinal cord injury (SCI) is a severe neurological condition with limited regenerative capacity and no effective curative treatments. Interleukin-13 (IL-13), an immunomodulatory cytokine, has shown therapeutic potential by promoting alternat...
Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia [0.03%]
受胰岛素和Ⅰ型胰岛样生长因子启发的治疗雄激素性脱发的自组装肽
Xingjie Hu,Lihao Guo,Yinghao Ding et al.
Xingjie Hu et al.
Androgenetic alopecia (AGA), the most prevalent form of hair loss, urgently requires breakthroughs in existing therapies due to limitations such as medication side effects, recurrence risks, and treatment inefficacy. Herein, we propose an i...
Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics [0.03%]
基于单细胞和空间转录组的生物材料介导的细胞图谱研究
Xiaokun Yang,Mingshu Huang,Huan Chen et al.
Xiaokun Yang et al.
Biomaterials serve as bridges between synthetic structures and biological systems, facilitating interactions with bodily tissues and regulating cellular responses. However, the intricate mechanisms governing cell-material interactions withi...
Mengqi Tong,Xi Kuang,Qiaoying Jiang et al.
Mengqi Tong et al.
The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency. To ...
Timed photothermal therapy combining fluorescence-on chemotherapy maximizes tumor treatment [0.03%]
结合荧光引导化疗的定时光热疗最大化肿瘤治疗效果
Runqun Tang,Ziyi Zhang,Xiaoyang Liu et al.
Runqun Tang et al.
Photothermal therapy (PTT) combined with chemotherapy is a promising strategy for tumor treatment. However, its efficacy is often limited by the uncertainty of the irradiation timing of the photothermal agent. Herein, we rationally designed...