GSH-responsive nanovaccine triggers immunogenic cell death and potent memory T cell immunity for durable, recurrence-free tumor eradication [0.03%]
谷胱甘肽响应型纳米疫苗通过诱导免疫性细胞死亡和长效的记忆T细胞免疫用于持久的无瘤生存率提升
Khang-Yen Pham,Thu Huyen Le Thi,Anil Giri et al.
Khang-Yen Pham et al.
Although nanovaccines hold promise for cancer immunotherapy, the engineering platforms that respond to tumor-specific cues and activate antitumor immunity remains challenging. Herein, a glutathione (GSH)-responsive immunogenic nanovaccine (...
Mild photothermal-responsive hydrogel with H2Se delivery for anti-infection and microenvironment remodeling to bone regeneration in diabetic osteomyelitis [0.03%]
一种用于糖尿病骨髓炎骨再生的抗感染和微环境重塑的温和光热响应水凝胶及其硒化氢传递功能
Junwei Su,Xinyue Liang,Junwei Yang et al.
Junwei Su et al.
Diabetic osteomyelitis, exacerbated by a hyperglycemic microenvironment, leads to increased bacterial infections and bone tissue destruction, raising the risk of amputation. Current antibiotic therapies are limited in effectiveness due to r...
Inhalable bioadhesive barrier for lung protection and clearance of fine particulate matter [0.03%]
一种吸入式生物黏附屏障用于肺保护和清除细颗粒污染物的新方法研究进展
Jiaming Liu,Na Yan,Mengrui Liu et al.
Jiaming Liu et al.
Fine particulate matter (PM) can bypass nasal filtration and accumulate in the lower respiratory tract, where prolonged deposition may cause chronic inflammation, pulmonary fibrosis, and other respiratory diseases. Although commercial nasal...
From plant to prosthesis: An engineered biomimetic disc repairs senescence-associated intervertebral disc degeneration in goats [0.03%]
从植物到假体：一种工程化的仿生椎间盘修复山羊的与衰老相关的椎间盘退行性病变
Liang Ma,Yukun Hu,Yao Wang et al.
Liang Ma et al.
Intervertebral disc degeneration (IVDD) is a multifactorial process driven by oxidative stress, inflammation, and cellular senescence, ultimately leading to disc destruction and functional loss. Current treatments can only alleviate symptom...
Fe3+-based nanovesicle mediated transferrin hijacking for glioblastoma stem cell tumoricidal treatment and postoperative recurrence inhibition [0.03%]
基于Fe3+的纳米囊泡介导转铁蛋白劫持治疗胶质母细胞瘤干细胞肿瘤并抑制术后复发
Fuming Liang,Wanyu Wang,Weiling Zhuo et al.
Fuming Liang et al.
Glioblastoma (GBM) currently still faces the challenges of limited chemotherapy efficacy and high risk of postoperative recurrence, despite the implementation of multimodal treatment approaches. Glioblastoma stem cells (GSCs), characterized...
A 'three-axis synergy' immunotherapeutic strategy for malignant bone tumors based on natural bioactives and bioactive materials [0.03%]
基于天然生物活性分子和生物活性材料的恶性骨肿瘤“三效协同”免疫治疗策略
Xiangjun Pan,Ruiyan Li,Xinyu Xu et al.
Xiangjun Pan et al.
This review presents an innovative "three-axis synergy" immunotherapeutic strategy for malignant bone tumors, combining natural bioactives with bioactive materials to overcome the challenges posed by the immunosuppressive microenvironment (...
A Heterogeneously structured Mg-Zn laminate alloy for gradient degradation behavior [0.03%]
用于梯度降解行为的异构Mg-Zn层状合金
Xiyue Zhang,Han Yu,Ruizhi Jia et al.
Xiyue Zhang et al.
In order to advance the application of magnesium alloys as short-term implants, there is a growing need to further regulate the temporal evolution of their degradation rates to better align with clinical requirements. However, it is difficu...
A dual-pronged strategy for bacterial keratitis: ROS-responsive hydrogel eye drops enabling potent deep-tissue antibacterial action and NETs modulation [0.03%]
一种治疗细菌性角膜炎的双管齐下策略：ROS响应性水凝胶滴眼液实现强力深组织杀菌作用及中和NETs
Yanan Wang,Zhuorui Dong,Haochen Yao et al.
Yanan Wang et al.
Effective treatment of bacterial keratitis is constrained by poor ocular drug bioavailability and tissue damage caused by bacterial invasion and the subsequent host inflammatory response. Motivated by molecular insights into the high mobili...
Submolecular modulation of PIEZO1 mechanotransduction with wireless tailor-made nanoswitches [0.03%]
无线纳米开关调控PIEZO1机械门控离子通道亚分子单元
Simão P B Teixeira,Alberto Pardo,Pablo Taboada et al.
Simão P B Teixeira et al.
PIEZO mechanoreceptors play critical roles in fundamental physiological processes such as proprioception or musculoskeletal biomechanics. However, their complex gating mechanisms and downstream signaling are still not completely understood,...
Recent advances in immunocompetent human skin-on-chip models: Construction strategies and biomedical applications [0.03%]
具有免疫功能的人体皮肤芯片模型的最新进展：构建策略及生物医学应用
Yudi Pang,Beiqin Liu,Jiwei Jiang et al.
Yudi Pang et al.
Human skin, as the body's largest organ and primary barrier, possesses a sophisticated immune microenvironment crucial for its defensive functions. Recent advancements in organ-on-a-chip technology have facilitated the development of biomim...