Modular living assembly of bone organoids with in situ guided vascularization [0.03%]
可在体内引导血管化的模块化骨器官组装体
Jingyi Ju,Huimin Fang,Junjin Jie et al.
Jingyi Ju et al.
Organoids have emerged as a powerful strategy to recapitulate tissue architecture and function, opening new avenues for regenerative medicine. However, clinical translation is hindered by limited control over the assembly of heterogeneous o...
Nano-to-macroscale dual core-shell structured bioartificial ligament improves outcomes of anterior cruciate ligament reconstruction in rats: A proof-of-concept study [0.03%]
纳米至宏观双重核壳结构生物人工韧带可改善大鼠前交叉韧带重建效果：一项概念验证研究
Haozhi Zhang,Yuanming An,Ying Luo et al.
Haozhi Zhang et al.
Over 400,000 anterior cruciate ligament (ACL) reconstructions are performed worldwide annually. The ability of patients to return to their pre-injury or adapted level remains limited. Although autografts and allografts are recognized as goo...
Stage-specific biomimetic nanoparticles reprogram osteoblast-adipocyte equilibrium for targeted osteoporosis therapy [0.03%]
阶段特异性类生物纳米粒子重新编程成骨细胞-脂肪细胞平衡以实现针对性的治疗骨质疏松症
Kehan Cai,Zhe Fan,Jun Tan et al.
Kehan Cai et al.
Cell membrane-camouflaged nanoparticles have emerged as powerful tools for targeted drug delivery; however, current strategies typically utilize membranes from static cell states, overlooking the dynamic functional evolution that occurs dur...
AI for bioactive materials: From material design to biological applications [0.03%]
基于人工智能的生物活性材料研究：从材料设计到生物学应用
Jiezhong Shi,Ting Liang,Marcin Heljak et al.
Jiezhong Shi et al.
Bioactive materials are engineered to actively interact with biological systems and induce favorable cellular and tissue responses. The development of bioactive materials is inherently challenging due to the complexity of the biological pro...
Oxygen-vacancy-engineered t-ZnO-CeO2 Schottky junction enhanced infectious bone regeneration via photoelectric-photocatalytic effects-induced mitochondrial quality control [0.03%]
氧空位工程t-ZnO-CeO2肖特基结通过光电信号-光催化作用诱导的线粒体质量控制促进感染性骨再生
Wanhao Yan,Xiaoli Guo,Zhe Shen et al.
Wanhao Yan et al.
The repair of infectious bone defects presents formidable challenges due to complex aetiologies, inflammatory immune microenvironment and bacterial invasion. Tetrapod-like zinc oxide (t-ZnO) exhibit great potential in infectious bone defect...
Topical framework nucleic acid transdermal delivery system for reprogramming cutaneous dendritic cells to maintain graft immune homeostasis [0.03%]
用于表皮树突状细胞重编以维持移植物免疫稳态的局部核酸递送系统框架
Xin Qin,Tong Wei,Zhaoying Zhang et al.
Xin Qin et al.
Immune rejection is a major challenge for the long-term survival of allogeneic skin grafts. Current immunosuppressive therapies are usually administered systemically to mitigate rejection; however, they have substantial side effects. Theref...
Countering postoperative immune suppression with a self-assembling dendritic cell nanovaccine [0.03%]
一种自组装树突状细胞纳米疫苗可对抗术后免疫抑制
Qiang Yang,Tongge Wang,Hongrui Zhang et al.
Qiang Yang et al.
Postoperative immune suppression, driven by transforming growth factor β (TGFβ)-mediated dendritic cell (DC) dysfunction, significantly impairs antigen-specific T cell responses and elevates cancer recurrence risk. A key mechanism is TGF...
Bone microenvironment-driven macro-galvanic coupling of Zn alloys: Mediating immune response and osteogenesis [0.03%]
骨微环境驱动的锌合金宏伽伐尼耦合：介导免疫反应和成骨作用
Chaoyang Sun,Bo Jia,Shuang Li et al.
Chaoyang Sun et al.
Biodegradable metals exhibit heterogeneous degradation patterns within complex physiological microenvironments, which frequently culminate in premature implant sequestration or failure. While traditional research paradigms have prioritized ...
Synergistic antibacterial effect of photocatalytic coatings activated by visible light and photodynamic therapy for rapid peri-implantitis treatment [0.03%]
可见光激活的光催化涂层与光动力疗法协同治疗快速种植体周炎效应
Bruna Egumi Nagay,Raphael Cavalcante Costa,Samuel Santana Malheiros et al.
Bruna Egumi Nagay et al.
Biofilm accumulation and subsequent implant-related infections pose significant challenges in the biomedical field. Photocatalytic coatings hold promise for antimicrobial efficacy; however, their effectiveness in dynamic polymicrobial infec...
Reconstructing protein conformations to activate follicular enzyme-nutrient reservoirs for reversing follicle aging [0.03%]
重构蛋白质构象以激活卵泡酶-营养库逆转卵泡衰老
Shifeng Ling,Mingyue Liu,Chen Meng et al.
Shifeng Ling et al.
Hair regeneration depends on a reservoir of follicular enzymes that regulate the microenvironment and provide metabolic support. However, in degenerative alopecia, this enzymatic reservoir is disrupted, impairing microenvironmental homeosta...