Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure [0.03%]
面向低流量稳定工作的离心血泵流体动力学设计：从表面到结构
Miaowen Jiang,Chunhao Yu,Yiming Huang et al.
Miaowen Jiang et al.
Long-lasting stability of the anticoagulant coating on centrifugal blood pumps (CBPs) is of vital importance to ensure the hemocompatibility of the blood circulation system therein. Heparin coatings are often prepared using static wet chemi...
Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives [0.03%]
用于骨再生的目标衰老细胞的生物材料：现状和未来展望
Haitong Wu,Qing Zhang,Jinhao Zhu et al.
Haitong Wu et al.
Bone defect treatment remains a significant clinical challenge, further exacerbated by the demographic transition toward an aging society. In elderly populations, the increased proportion of senescent cells emerges as a fundamental determin...
Adaptive bioactivable nanosystems for synergistic myocardial infarction therapy using traditional pharmaceutics [0.03%]
基于传统药学的适应性生物活性纳米系统协同治疗心肌梗死
Shuai Mao,Yubin Liang,Zikang Chen et al.
Shuai Mao et al.
Heart failure resulting from myocardial infarction (MI) is a leading global health concern. Current revascularization therapies cannot fully restore the infarcted myocardium or prevent maladaptive ventricular remodeling. Traditional Chinese...
A long-term quasi-equivalent in vitro study of high-strength Zn alloy interference screws for anterior cruciate ligament reconstruction [0.03%]
一种高强度锌合金前交叉韧带重建固定螺钉的长期准等同体外研究
Bo-Yao Li,Zhang-Zhi Shi,Xiang-Min Li et al.
Bo-Yao Li et al.
Biodegradable Zn alloy interference screws are promising for anterior cruciate ligament reconstruction. However, previous in vitro studies not only predominantly focus on short-term (≤30 days) immersion, but also neglect influence of crevi...
Activatable companion theranostics for dual-modality imaging-escorted pyroptosis-propelled synergistic cancer therapy [0.03%]
用于双模式成像导向的焦亡增强协同癌症治疗的激活型伴随精准诊疗体系
Yilin Wan,Yurong Liu,Weihua Wen et al.
Yilin Wan et al.
Companion diagnostics (CDx) plays a pivotal role in precision medicine for cancer treatment. However, conventional CDx are often limited by their inability to provide real-time monitoring of cancer progression and therapeutic responses. Her...
Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity [0.03%]
一种级联靶向递送平台，通过增强抗原交叉呈递和STING活化来产生持久的细胞免疫能力
Yuan Xue,Shuting Bai,Yating Wang et al.
Yuan Xue et al.
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation. Here, we engineered a series of nano-em...
Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential [0.03%]
集成血管的微流体芯片-子宫内膜复杂系统：线粒体功能和旁分泌信号增强再生潜能
Yongdong Dai,Fanxuan Zhao,Qiuli Chen et al.
Yongdong Dai et al.
Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte...
Yingting Zhang,Yue Li,Fuxiao Wang et al.
Yingting Zhang et al.
The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication. Here, we established novel, physiologically relevant senescent liver and bone organoid mo...
Toxoplasma gondii-derived nanocarriers: leveraging protozoan membrane biology for scalable immune modulation and therapeutic delivery [0.03%]
弓形虫衍生的纳米载体：利用原生动物膜生物学进行可扩展免疫调节和药物输送
Jiating Chen,Pengfei Zhang,Hongjuan Peng et al.
Jiating Chen et al.
Cell membrane-derived nanovesicles (CMNVs) are nanoscale lipid bilayer structures obtained from cellular membranes that serve as biomimetic drug delivery platforms, offering immune evasion, targeting, and surface functionalization capabilit...
Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures [0.03%]
一种负载双药的预混镁-三镁磷灰石骨水泥调节骨平衡治疗骨质疏松性椎体压缩骨折
Jiawei Liu,Jinjin Zhu,Takashi Goto et al.
Jiawei Liu et al.
Osteoporotic vertebral compression fractures (OVCF) have emerged as a significant public health concern. Traditionally, poly(methyl methacrylate) (PMMA) has been utilized in clinical to treat OVCF. Nevertheless, its poor degradability, unco...