Curcuma-derived nanovesicle-loaded ROS-responsive hydrogels reprogram iron metabolism to enhance cartilage regeneration after microfracture [0.03%]
微骨折后姜黄素来源的纳米囊泡负载ROS响应性水凝胶重编铁代谢以增强软骨再生
Yuhao Mu,Hao Li,Ruiyang Zhang et al.
Yuhao Mu et al.
Microfracture (MF) is widely used for cartilage repair, but it often yields limited clinical benefit because it predominantly induces fibrocartilage formation. However, the mechanisms underlying this fibrocartilaginous repair remain insuffi...
Design and applications of barrier membranes for guided bone regeneration [0.03%]
屏障膜的制备及在引导骨再生中的应用研究进展
Yue Liu,Hao Zhang,Lingkun Zhang et al.
Yue Liu et al.
Despite the placement of millions of dental implants annually, one-quarter to one-half of cases require concurrent guided bone regeneration (GBR), where a recent meta-analysis of 100 studies reported an approximately 26% complication rate t...
-30°C-operable bioadhesive hydrogel sensors for embryonic-like skin regeneration and real-time wound monitoring [0.03%]
-30℃可操作的生物胶态水凝胶传感器促进胚胎类皮肤再生和实时伤口监测
Linhao Hou,Wei Jing,Xueying Zhang et al.
Linhao Hou et al.
Hydrogel-based biosensors are promising for on-skin and in situ wound monitoring owing to their softness and biocompatibility, yet their practical deployment remains hindered by subzero failure caused by water crystallization, unstable adhe...
In vivo circRNA-engineered macrophages mediate localized MMP9 neutralization to rejuvenate aged bone [0.03%]
体内circRNA工程化巨噬细胞介导局部MMP9中和以使衰老骨骼恢复活力
Daoyu Zhu,Shifeng Ling,Haoyu Fang et al.
Daoyu Zhu et al.
Aging causes osteoporosis, delayed fracture repair, and osteoarthritis, but mechanisms and therapies remain unclear. Transcriptomics of serum and bone from older patients showed marked MMP9 upregulation, highlighting systemic MMP9 neutraliz...
Catalytic lactate-regulatory nanosystems attenuate cellular senescence for atherosclerosis amelioration [0.03%]
催化乳酸调控纳米系统可减轻细胞衰老以改善动脉粥样硬化病情
Chang Wang,Chunmei Wang,Shaozhen Wu et al.
Chang Wang et al.
Endothelial senescence is a pivotal driver in the pathogenesis of atherosclerosis (AS), a process accompanied by metabolic reprogramming and increased lactate (LA) production. The accumulated LA stimulates reactive oxygen species (ROS) gene...
An immuno-chemotherapeutic bone scaffold for tumor eradication and bone regeneration in drug-resistant osteosarcoma [0.03%]
用于药物耐药性骨肉瘤肿瘤消融和骨再生的免疫化学治疗骨支架
Zuyun Yan,Yiwen He,Jin Zeng et al.
Zuyun Yan et al.
Postoperative management of osteosarcoma remains hindered by several critical challenges, including platinum-based chemoresistance, insufficient antitumor immune responses, and the difficulty of synchronously repairing large bone defects. A...
Spatiotemporal regulation of neutrophil-mediated immune cascades via engineered PEEK surfaces restores osseointegration in diabetes [0.03%]
调控糖尿病中工程化聚醚酮酮表面介导的中性粒细胞免疫级联反应的时空性以恢复骨结合
Jie Tan,Dazhi Yang,Lei Qin et al.
Jie Tan et al.
Diabetes mellitus compromises bone regeneration and increases implant failure rates, posing persistent challenges in orthopedic and dental therapies. Although macrophage-centered immunomodulation has been widely investigated, the role of ne...
A microenvironment-adaptive bilayer composite dressing for disrupting MRSA biofilms and promoting wound regeneration via ROS-mediated immune regulation [0.03%]
一种适应微环境的双层复合敷料通过ROS介导的免疫调节破坏MRSA生物膜并促进伤口再生
Jianan Li,Zhongwu Bei,Jian Hua et al.
Jianan Li et al.
Methicillin-resistant Staphylococcus aureus (MRSA) biofilm-infected wounds remain difficult to treat because persistent biofilm protection, oxidative stress imbalance, and unresolved inflammation jointly hinder tissue repair. Here, we devel...
A cell motility-based selective hydrogel enables rapid generation of nerve-repairing blood clots [0.03%]
一种基于细胞运动的筛选水凝胶实现快速生成神经修复血凝块
Wenbo He,Yi Zhang,Wenbi Wu et al.
Wenbo He et al.
Blood clots containing nutrients can promote multiple tissue repair, but their use in nerve repair is limited due to the risk of red blood cell-related neurotoxicity. We presented a cell motility-based selective hydrogel for the rapid gener...
Degradation of biodegradable orthopedic screws does (not) elevate tissue heating under Magnetic Resonance Imaging: Implications for next generation implants [0.03%]
可生物降解骨板的退化（不）会在磁共振成像下提升组织加热：对下一代植入物的影响
Mostafa Berangi,Helmar Waiczies,Nandita Saha et al.
Mostafa Berangi et al.
Magnesium (Mg) alloy screws represent promising biodegradable orthopedic implants owing to their biocompatibility, mechanical strength, and gradual resorption, thereby obviating the need for secondary removal surgery. However, their electri...