Dual targeting of lipid metabolic reprogramming and immunosuppressive sentinel lymph nodes potentiates anti-metastatic therapy for triple negative breast cancer [0.03%]
双重靶向脂质代谢重编程和免疫抑制哨点淋巴结可增强三阴性乳腺癌抗转移疗法
Tingting He,Xuemei Liao,Shuangquan Gou et al.
Tingting He et al.
Inducing immunogenic cell death (ICD) in cancer cells provides a promising approach in immunotherapy, however, oxidative stress relief and metabolic plasticity enhancement limit the immune-stimulating effect of traditional ICD inducer in se...
Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms [0.03%]
类器官工程中的动态水凝胶力学：从基质设计到转化范例
Chenjia Zhang,Yue Shen,Mingyang Huang et al.
Chenjia Zhang et al.
The extracellular matrix (ECM) serves as a dynamic biomechanical regulator of cellular behavior, yet conventional 3D culture systems, such as Matrigel, lack the spatiotemporal control required to dissect mechanotransductive mechanisms in or...
Plant-derived vesicle-like nanoparticles for immunomodulation: Mechanisms and applications [0.03%]
植物衍生的类似囊泡的纳米颗粒在免疫调节中的机制及应用研究
Simin Wang,Yanli Zhang,Yuting Zeng et al.
Simin Wang et al.
Immune dysregulation can result in sustained activation of the immune system, leading to systemic chronic inflammation. This condition significantly disrupts immune homeostasis and is intimately associated with the onset of numerous chronic...
Bone matrix-mimetic multi-ion doped hydroxyapatite nanorod arrays for enhanced immuno-osteogenesis and prevention of aseptic loosening [0.03%]
类骨质多离子掺杂羟基磷灰石纳米线阵列促进免疫成骨和防治无菌性松动
Jing Ye,Bo Li,Meng Yu et al.
Jing Ye et al.
Inflammatory responses triggered by foreign body rejection or detached wear particles are major contributors to the failure of titanium (Ti)-based orthopedic implants. One of the most common complications is aseptic loosening. To address th...
Human iPSC-derived cardiac-specific extracellular matrix scaffolds for cardiomyocyte maturation and post-myocardial infarction repair [0.03%]
人多能干细胞来源的心脏谱系分化细胞外基质支架促进心肌细胞成熟和心梗修复
Dhavan Sharma,Wenkai Jia,Alvis Chiu et al.
Dhavan Sharma et al.
Myocardial infarction (MI) remains a leading cause of heart failure due to the limited regenerative capacity of the adult myocardium. The therapeutic efficacy of current engineered cardiac patches is hindered by their simplistic scaffold co...
Synergistic enhancement of efferocytosis and cholesterol efflux via macrophage biomimetic nanoparticle to attenuate atherosclerosis progression [0.03%]
通过巨噬细胞模拟纳米颗粒增强促凋亡和胆固醇流出以减缓动脉粥样硬化发展
Shiteng Cai,Jinfeng Gao,Xueyi Weng et al.
Shiteng Cai et al.
Atherosclerosis is the leading cause of myocardial infarction and stroke, which is characterized as a chronic inflammatory disease due to the aberrant accumulation of apoptotic cells in the necrotic core. Previous CD47-SIRPα checkpoint blo...
Coenzyme-based elastomeric adhesive patch as iron ion capturer to regulate iron metabolism for diabetic oral ulcer repair [0.03%]
一种基于辅酶的弹性粘合补丁作为铁离子捕获剂以调节铁代谢修复糖尿病口腔溃疡
Rong Yang,Jiaxing Shao,Qian Zhang et al.
Rong Yang et al.
Iron metabolism imbalance under high-glucose and nutrient-rich conditions is a key factor inhibiting the healing of diabetic oral ulcers. This study confirms the extensive iron accumulation and ferroptosis occurrence in diabetic oral ulcers...
Zwitterionic multifunctional coatings with strong hydration for ureteral stents to inhibit infectious encrustation [0.03%]
用于输尿管支架抑制感染性沉积的强亲水性多功能 zwit er离子涂层
Yucong Wu,Zhenqing Li,Xiufang Wen et al.
Yucong Wu et al.
In the complex urinary environment, an effective method is needed to combat ureteral stent encrustation. Herein, recognizing that the adsorption of mineral salts is the initial step in the encrustation process, we utilized the barrier effec...
Snake-fangs-bioinspired intelligently-responsive two-stage AIE gen-containing microneedle-based platform for integrated photodynamic infected-wound management and visual therapeutic diagnosis [0.03%]
蛇牙启发的智能响应性两阶段AIE基因含微针平台用于光动力感染创面管理及视觉治疗诊断一体化技术
Lijuan Chen,Xiaomin Luo,Hao Yang et al.
Lijuan Chen et al.
The efficient treatment of prevalent drug-resistant (DR) bacteria-infected wounds caused by the clinical use of conventional antibiotics remains a significant challenge. Here, a well-integrated intelligent drug-releasing, photodynamic thera...
Core-shell engineered Col/Cs@ECM microspheres for macrophage-targeted intracellular drug release in RA therapy [0.03%]
用于RA治疗的针对巨噬细胞的胞内药物释放的核壳工程化胶原/铯@ ECM微球
Xiyue Duan,Kepeng Hu,Jiawei Wang et al.
Xiyue Duan et al.
The imbalance of macrophage polarization between M1 and M2 phenotypes in rheumatoid arthritis (RA) results in a persistent inflammatory cascade. Activating M2 anti-inflammatory polarization, which remove excess extracellular matrix (ECM) vi...