Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration [0.03%]
聚醚醚酮材料离子/免疫微环境的自发动态调控以实现材料的序贯抗感染和骨整合性能
Junjie Zhou,Yinghao Wu,Ji Tan et al.
Junjie Zhou et al.
Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously d...
Preclinical research models for evaluating the biocompatibility of bioresorbable metallic cardiovascular stents: A comparative review [0.03%]
用于评估可降解金属心血管支架生物相容性的临床前研究模型：比较型综述
Samuel Hansen,Thuy Anh Bui,Xiaoxue Xu et al.
Samuel Hansen et al.
Cardiovascular stents are widely used to treat atherosclerosis by relieving vascular obstruction and providing structural support after coronary angioplasty. Bioresorbable metallic stents represent a promising alternative to conventional co...
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis [0.03%]
葡萄糖代谢紊乱通过调控SLC7A11 / GSH / GPX4轴同时促进二硫化物、铜和铁死亡
Mengsi Zhang,Hao Zheng,Hao Jin et al.
Mengsi Zhang et al.
As one of the key targets of tumor metabolic therapy, glucose dyshomeostasis by disrupting glucose metabolism possesses the potential to reverse therapeutic resistance of a variety of regulated cell deaths (RCDs), but the functional pathway...
Biomimetic aligned bacterial cellulose dressing containing polydeoxyribonucleotide for promoting wound healing [0.03%]
一种聚脱氧核糖核苷酸凝胶促进伤口愈合的研究
Xiaoqian Zhu,Fan Liu,Tuwei Jin et al.
Xiaoqian Zhu et al.
Chronic or non-healing wounds present a significant challenge in daily life, leading to increased interest in the design of wound dressings with enhanced healing capabilities. In this study, a bacterial cellulose (BC) membrane with an align...
Bioengineering an improved three-dimensional vascularized co-culture model for studying Neuron-Microglia interactions [0.03%]
用于研究神经元-小胶质细胞相互作用的改进型三维血管共培养模型的生物工程学研究
Yinhe Han,Lina Guo,Mingqi Wang et al.
Yinhe Han et al.
Interactions among neurons, microglia, and endothelial cells (ECs) -the principal components of the neurovascular unit (NVU)-are vital for maintaining central nervous system (CNS) homeostasis and are implicated in numerous neurological diso...
A naturally derived lipopeptide lipid nanoparticle platform enabling multiple nucleic acids delivery [0.03%]
一种天然衍生的脂肽脂质纳米颗粒平台，可同时递送多种核酸药物
Han Xiao,Bailin Feng,Dongdong Gao et al.
Han Xiao et al.
Lipid nanoparticles (LNPs) have emerged as versatile platforms for nucleic acid-based therapies. Despite advancements, key challenges remain in achieving tissue-specific delivery while maintaining low toxicity and tunable properties essenti...
Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing [0.03%]
用于糖尿病伤口愈合的可喷涂水凝胶海绵实现神经血管微环境重构及炎症调控
Xiaozhen Zhou,Pengchao Ma,Yihao Liu et al.
Xiaozhen Zhou et al.
Diabetic wounds are characterized by chronic inflammation, vascular insufficiency, and peripheral neuropathy, which collectively disrupt the neurovascular microenvironment essential for coordinated tissue regeneration. However, strategies t...
Bacterial-engineered self-stabilizing ultra-small AgCu nanoparticles for dual antimicrobial-anticancer therapy [0.03%]
细菌工程稳定型超小型AgCu纳米颗粒的双抗菌抗肿瘤疗法研究
Zhi Peng,Fang Zhou,Xiong-Gang Yang et al.
Zhi Peng et al.
Bimetallic silver-copper nanoparticles (AgCu NPs) exhibit enhanced antibacterial properties compared to their monometallic counterparts; however, their clinical translation is limited by poor stability and biocompatibility. Here, we unveil ...
Hemoglobin-crosslinked drug-loaded silk fibroin porous scaffold for long-segment tracheal defect repair: An integrated strategy leveraging dynamic mechanical biomimicry and infection control [0.03%]
一种集成了动态力学仿生和抗感染控制于一体的基于负载药物的交联血红蛋白丝素多孔支架修复长节段气管缺损的新策略
Wei Gao,Zhecheng Zha,Leyan Chen et al.
Wei Gao et al.
The clinical repair of long-segment tracheal defects (LSTDs) remains a formidable challenge, primarily due to the dynamic mechanical mismatch of current implantable substitutes and high rates of postoperative infection. To address these cri...
Inducing pyroptosis and reprogramming macrophage via zeolitic imidazolate framework encapsulated-fullerene for two-pronged tumor immunotherapy [0.03%]
封装富勒烯的咪唑骨架沸石复合材料诱导肿瘤细胞焦亡和巨噬细胞重编程的双重免疫治疗
Zihao Sun,Lei Liu,Jiacheng Sun et al.
Zihao Sun et al.
Immunogenic antigen downregulation combined with an immunosuppressive tumor microenvironment (TME) remain major barriers to effective treatment of "cold" tumors. Here, we report a dual-functional nanotherapy that integrates C70 fullerene wi...