Lymphatic incorporated biomimetic scaffold enhances Osteoangio-lymphogenic coupling via HIF-1α mediated mitochondrial reprogramming for osteoporotic bone repair [0.03%]
缺血性骨缺损修复的生物模拟支架通过HIF-1α介导的线粒体重组促进成软骨、血管和淋巴生成耦合反应
Weipeng Sun,Qing Lin,Biyi Zhao et al.
Weipeng Sun et al.
Recent studies have challenged the notion that bone tissue lacks lymphatic vessels, highlighting their essential role in bone regeneration. Effective bone repair relies on the interplay of osteogenesis, angiogenesis, and lymphangiogenesis. ...
Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging [0.03%]
硫酸化壳聚糖通过骨骼干细胞年轻化增强BMP-2介导的衰老小鼠椎体融合效果
Xiaogang Wang,Dongao Huang,Luli Ji et al.
Xiaogang Wang et al.
Spinal degenerative diseases in elderly patients often require spinal fusion, but outcomes are limited by an aging microenvironment and stem cell dysfunction or depletion. In this study, we developed a bone morphogenetic protein-2 (BMP-2)/s...
An injectable hyaluronic acid-silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing [0.03%]
一种含有精氨酸和荭草素的透明质酸硅醇水凝胶，用于免疫调节和增强糖尿病伤口愈合
Renwen Wan,Zhiheng Lin,Mowen Xu et al.
Renwen Wan et al.
Diabetic wound healing is a significant complication of diabetes mellitus, characterized by prolonged healing times, heightened infection risks, and potential amputations, necessitating innovative therapeutic approaches. This study aims to ...
Immunomodulatory copper-based polyphenol nanozyme for diabetic infectious wound healing via NIR amplified cuproptosis bacteriostat in synergy with ferroptosis inhibition anti-inflammation [0.03%]
一种免疫调控的铜基类酚纳米酶，通过近红外增强的细菌生长抑制剂和铁死亡协同抗炎作用促进糖尿病感染伤口愈合
Huyang Gao,Juan Luo,Xixi Chen et al.
Huyang Gao et al.
Diabetic infectious wound is usually in the environment of high glucose levels and immune disorder. It always results in high reactive oxygen species (ROS) levels, serious immune dysfunction, and extreme susceptibility to infection, delayin...
Point-of-care treatment of acute skin wound by portable in-situ electrospinning nanofiber dressings with rapid hemostasis, anti-infection, and angiogenesis effects [0.03%]
具有快速止血、抗菌和促血管生成作用的便携式现场静电纺纳米纤维敷料的即时伤口治疗
Yechuan Deng,Min Xing,Yuanming Cao et al.
Yechuan Deng et al.
The increasing prevalence of acute traumatic injuries caused by traffic accidents, and natural disasters presents multifaceted challenges such as hemorrhages in irregular wounds and being susceptible to microbes. Herein, in situ point-of-ca...
Autograft-matching wireless bioelectronic conduits: Magneto-electric coupling enabled taurine metabolism activation for peripheral nerve repair [0.03%]
自体移植匹配无线生物电子通路：磁电耦合激活牛磺酸代谢促进外周神经再生修复
Anmin Wang,Wenjing Song,Wentai Guo et al.
Anmin Wang et al.
Peripheral nerve injuries remain a clinical challenge due to the limitations of autografts and unstable electrical signals in existing bioelectronic therapies. It is necessary to develop innovative strategies to achieve wireless, controllab...
Jahn-Teller distortion-engineered self-propelled nanorobots for mitochondrial targeting and bioenergetic disruption in tumor therapy [0.03%]
一种用于肿瘤治疗的线粒体靶向和生物能破坏的Jahn-Teller畸变工程自主推进式纳米机器人
Tianying Luo,Mingyi Zhang,Jia Xu et al.
Tianying Luo et al.
Mitochondrial metabolism plays a pivotal role in tumor progression, yet effective therapeutic targeting remains constrained by limited tissue penetration and lack of spatiotemporal control. Herein, we present Jahn-Teller distortion-engineer...
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction [0.03%]
钼介导的抗氧化内稳外助协同作用通过重建线粒体内环境平衡缓解急性肾损伤
Qiaohui Chen,Zuoxiu Xiao,Xiaohong Ying et al.
Qiaohui Chen et al.
Acute kidney injury (AKI) progression is driven by mitochondrial redox collapse in proximal tubular epithelial cells (PTECs), where reactive oxygen species (ROS) surge and molybdenum (Mo) metabolic dysregulation create an "oxidative storm-d...
Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation [0.03%]
负载MSCs外泌体和ZIF-8的水凝胶支架通过协调骨再生免疫调节及成骨作用促进骨折修复
Yunhui Si,Xiaorong Li,Shuao Dong et al.
Yunhui Si et al.
The limited bone regeneration and suboptimal immune responses constitute the major challenges in repairing critical-sized bone defects. As an emerging therapeutic modality, mesenchymal stem cell-derived exosomes (MSC-Exos) exhibit promising...
3D printing of chitosan hydrogel reinforced with tubular nanoclay for hemostasis and infected wound healing [0.03%]
用于止血和感染伤口愈合的纳米粘土增强式壳聚糖水凝胶的三维打印技术
Xiangyu Chen,Youquan Zhou,Shuiqing Zhou et al.
Xiangyu Chen et al.
Developing hydrogel dressings capable of rapid hemostasis and accommodating irregular wounds is crucial for infected wound healing. Customizable 3D-printed hydrogels, highly sought after for wound management, remain an ongoing challenge due...