Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation [0.03%]
锂调节锌基植入物的生物降解以通过免疫调节促进骨整合
Danni Shen,Wei Qiao,Xiaoxue Xu et al.
Danni Shen et al.
The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegrad...
Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis [0.03%]
纳米MgO负载热敏性HPCH@HA水凝胶通过骨免疫调节加速原位骨修复并促进血管生成和成骨作用
Feifei Ni,Longkang Chang,Yizhong Peng et al.
Feifei Ni et al.
Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic differentiation, and mineralization. Bio...
Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration [0.03%]
自组装杂化水凝胶微球构建骨髓仿生微环境用于骨再生
Zhi He,Peilun Hu,Zifan Li et al.
Zhi He et al.
Bone marrow (BM), a natural niche rich in growth factors and bone marrow mesenchymal stem cells (BMSCs), provides an optimal regenerative microenvironment and is widely used in clinical applications. However, the limited proliferative capac...
Three-dimensional cell sheet model improves in vitro prediction accuracy of osteogenic potential for biodegradable magnesium-based metals [0.03%]
三维细胞片模型可提高可降解镁基金属体外成骨潜能预测准确性
Liangwei Chen,Guanxi Wu,Siyu Liu et al.
Liangwei Chen et al.
Biodegradable metals have been increasingly utilized clinically due to their biosafety and pro-osteogenic properties. However, conventional monolayer cell-based preclinical safety evaluation methods based on ISO10993-5 consistently indicate...
Injectable sustained-release danshensu sodium-loaded nanoparticle hydrogel targets macrophages to improve myocardial microenvironment for myocardial infarction treatment [0.03%]
一种可注射长效丹参素钠纳米颗粒水凝胶，用于靶向心肌成纤维细胞以改善心肌微环境治疗心肌梗死
Jianqiu Yang,Jing Wang,Zhihua Zeng et al.
Jianqiu Yang et al.
Myocardial infarction (MI) induces cardiomyocyte necrosis, inflammation, fibrosis, and ventricular remodeling, leading to heart failure. To address this, we developed an intelligent cardiac patch, SMM@Gel, composed of a reactive oxygen spec...
Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration [0.03%]
基于NIR-II纳米载体的糖尿病骨微环境整体调控促进骨骼再生研究
Xudong Xie,Junli Yang,Chong Ding et al.
Xudong Xie et al.
Diabetic conditions impair bone regeneration due to dysregulated macrophage polarization and inflammatory imbalance. Current therapies often fail to address systemic immune homeostasis. Herein, a bone-targeted nanoplatform (abbreviated as A...
Photocatalytic CO-releasing spray hydrogel for in situ postoperative cancer treatment [0.03%]
一种用于术后癌症治疗的光催化一氧化碳释放喷雾水凝胶
Zaiyan Wang,Jianxiang Zhu,Bobin Mi et al.
Zaiyan Wang et al.
The high invasiveness and metastatic potential of breast cancer increase the risk of postoperative recurrence. To address this issue, a composite hydrogel drug delivery system based on sodium alginate (SA) has been developed for the in situ...
Lactobacillus extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing [0.03%]
由乳酸菌外泌体驱动的释氧光热水凝胶重编程巨噬细胞并促进血管生成以加速糖尿病伤口愈合
Pingyun Yuan,Meng Deng,Xueru Li et al.
Pingyun Yuan et al.
Chronic wound healing remains clinically challenging due to insufficient angiogenesis coupled with persistent inflammatory microenvironments. Macrophage M2 polarization plays a pivotal role in resolving inflammation and promoting angiogenes...
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer [0.03%]
用于结直肠癌肝转移抑制和奥沙利铂耐药逆转的CRCs-CAFs交叉对话靶向纳米传递系统
Heshi Liu,Caina Xu,Pai Wang et al.
Heshi Liu et al.
The five-year survival rate of patients with colorectal cancer (CRC) liver metastasis is less than 30 %, and chemotherapy resistance and metastatic microenvironment remodeling are the current treatment bottlenecks. Cancer-associated fibrobl...
Bioinspired porous core-shell microspheres with spatiotemporal delivery coordinate immunomodulatory-osteogenic coupling via NF-κB/P-STAT6 and Rho/MAPK signaling for enhanced calvarial regeneration [0.03%]
仿生多孔核壳微球通过NF-κB/P-STAT6和Rho/MAPK信号实现免疫调节-成骨偶联的时空递药协调促进颅顶缺损再生修复
Jiahe Zheng,Chengrun Li,Qingxia Zhang et al.
Jiahe Zheng et al.
Critical-sized calvarial defects remain a formidable clinical challenge due to dyssynchronous immunomodulation-osteogenesis coupling and unregulated growth factor release. Here, a bioinspired porous core-shell microsphere system (GCI@HPPS) ...