A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment [0.03%]
一种五效合一的新型MOF改性注射用温敏粘附性水凝胶促进牙周炎肺泡骨再生：抗菌、止血、免疫重编程、促骨/血管生成及招募效应
Shiyuan Yang,Yan Zhu,Chunxiao Ji et al.
Shiyuan Yang et al.
Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogen...
An NIR-propelled janus nanomotor with enhanced ROS-scavenging, immunomodulating and biofilm-eradicating capacity for periodontitis treatment [0.03%]
一种增强型ROS清除、免疫调节和生物膜消除能力的近红外推进Janus纳米马达用于牙周炎治疗
Xuan Bai,Wenan Peng,Ying Tang et al.
Xuan Bai et al.
Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle to effectively address the persistent bio...
Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform [0.03%]
利用酶催化纳米平台中断不利反馈环以协调缺氧M1巨噬细胞极化从而实现类风湿关节炎的协同治疗
Dong Guo,Hui Liu,Sheng Zhao et al.
Dong Guo et al.
A detrimental feedback loop between hypoxia and oxidative stress consistently drives macrophage polarization toward a pro-inflammatory M1 phenotype, thus persistently aggravating rheumatoid arthritis (RA) progression. Herein, an enzyme-cata...
Intrinsically bioactive multifunctional Poly(citrate-curcumin) for rapid lung injury and MRSA infection therapy [0.03%]
用于快速肺损伤和MRSA感染治疗的固有生物活性多功能聚(柠檬酸-姜黄素)
Tongtong Leng,Long Zhang,Junping Ma et al.
Tongtong Leng et al.
Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction. The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side effects. Herein, we de...
Protonated-chitosan sponge with procoagulation activity for hemostasis in coagulopathy [0.03%]
用于凝血病止血的具有促凝作用的质子化壳聚糖海绵
Zhenhua Huang,Dong Zhang,Laiqiang Tong et al.
Zhenhua Huang et al.
Hemostatic materials are essential for managing acute bleeding in medical settings. Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains incompletely understood. We unexpectedly discovered that certain protonated-c...
Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts [0.03%]
工程化血管内皮细胞囊泡促进小直径血管移植物的内皮覆盖和再生成组装
Zihao Wang,Mengxue Zhou,Mengyu Li et al.
Zihao Wang et al.
Current gold standard for the replacement of small-diameter blood vessel (ID < 4 mm) is still to utilize the autologous vessels of patients due to the limitations of small-diameter vascular grafts (SDVG) on weak endothelialization, intimal ...
STAT3-specific nanocarrier for shRNA/drug dual delivery and tumor synergistic therapy [0.03%]
STAT3特异性纳米载体介导的shRNA/药物协同递送及抗肿瘤治疗研究
Le Sun,Jishang Sun,Cuiyao Li et al.
Le Sun et al.
Non-small cell lung cancer (NSCLC) is a major disease with high incidence, low survival rate and prone to develop drug resistance to chemotherapy. The mechanism of secondary drug resistance in NSCLC chemotherapy is very complex, and studies...
Injectable citrate-based polyurethane-urea as a tug-of-war-inspired bioactive self-expansive and planar-fixing screw augmented bone-tendon healing [0.03%]
基于柠檬酸的聚氨酯-聚脲骨腱结合可注射植入螺钉促进骨腱愈合研究
Meihan Tao,Zhou Fang,Yuting Zhu et al.
Meihan Tao et al.
Inspired by tug-of-war, a game-changing bone-tendon fixation paradigm was developed. Specifically, injectable citrate-based bioactive self-expansive and planar-fixing screw (iCSP-Scr) consisting of reactive isocyanate (NCO) terminalized cit...
Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis [0.03%]
薄荷醇嵌入水凝胶递送酪氨酸激酶抑制剂治疗银屑病：预防、治疗及复发管理
Yuhsien Lai,Xuesong Wu,Zhuoyu Jiang et al.
Yuhsien Lai et al.
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i)...
Cartilage lacuna-biomimetic hydrogel microspheres endowed with integrated biological signal boost endogenous articular cartilage regeneration [0.03%]
一种软骨再生的仿生水凝胶微球及其制备方法和应用
Hao Li,Tianyuan Zhao,Zhiguo Yuan et al.
Hao Li et al.
Despite numerous studies on chondrogenesis, the repair of cartilage-particularly the reconstruction of cartilage lacunae through an all-in-one advanced drug delivery system remains limited. In this study, we developed a cartilage lacuna-lik...