Environmental Toxin Acrolein Alters Levels of Endogenous Lipids, Including TRP Agonists: A Potential Mechanism for Headache Driven by TRPA1 Activation [0.03%]
环境毒素丙烯醛改变内源性类脂水平（包括瞬时受体电位通道激动剂）：一种由TRPA1激活引起的头痛的潜在机制
Emma Leishman,Phillip E Kunkler,Meera Manchanda et al.
Emma Leishman et al.
Exposure to airborne toxins can trigger headaches, but the mechanisms are not well understood. Some environmental toxins, such as acrolein, activate transient receptor potential ankyrin 1 (TRPA1), a receptor involved in pain sensation that ...
Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain [0.03%]
炎症和神经损伤对作为疼痛指标的小鼠自主行为影响较小
Tayler D Sheahan,Edward R Siuda,Michael R Bruchas et al.
Tayler D Sheahan et al.
It has been suggested that the lack of rodent behavioral assays that represent the complexities of human pain contributes to the poor translational record of basic pain research findings. Clinically, chronic pain interferes with patient mob...
Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation? [0.03%]
迷走神经刺激的心理效应部分介导迷走神经镇痛吗？
Eleni Frangos,Emily A Richards,M Catherine Bushnell
Eleni Frangos
There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possi...