Translation regulation and pain special issue editorial for neurobiology of pain [0.03%]
神经生物学疼痛专题评论：翻译调控和疼痛
Theodore J Price
Theodore J Price
Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice [0.03%]
溶血磷脂酸LPA1和LPA3受体在小鼠晚期组织型纤溶酶原激活物诱导的中枢性卒中后痛觉维持中的作用
Hiroshi Ueda,Hiroyuki Neyama,Keita Sasaki et al.
Hiroshi Ueda et al.
We developed a mouse model for central post-stroke pain (CPSP), a centrally-originated neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed by photo-irradiation of left middle cerebral artery (MCA) to g...
Human-like cutaneous neuropathologies associated with a porcine model of peripheral neuritis: A translational platform for neuropathic pain [0.03%]
人源化皮肤神经病变与外周神经炎猪模型相关：外周神经痛的转化平台
Frank L Rice,David Castel,Elizabeth Ruggiero et al.
Frank L Rice et al.
Despite enormous investment in research and development of novel treatments, there remains a lack of predictable, effective, and safe therapeutics for human chronic neuropathic pain (NP) afflictions. NP continues to increase among the popul...
Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test [0.03%]
大鼠甲醛试验中扑热息痛的镇痛作用与5-ht1a/1b受体的关系
A Roca-Vinardell,E Berrocoso,M Llorca-Torralba et al.
A Roca-Vinardell et al.
The mechanism of analgesic action of paracetamol (acetominophen) remains still unknown. However, a relationship between serotonergic system and the effect of paracetamol has been previously demonstrated. The serotonin activity in the brains...
Emiko Senba,Katsuya Kami
Emiko Senba
Physical exercise has been established as a low-cost, safe, and effective way to manage chronic intractable pain. We investigated the underlying mechanisms of exercise-induced hypoalgesia (EIH) using a mouse model of neuropathic pain (NPP)....
Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain [0.03%]
mTOR介导的翻译调节在慢性疼痛脑机制中的作用研究
Chulmin Cho,Vassilia Michailidis,Loren J Martin
Chulmin Cho
In the spinal cord, altered protein transcription and translation have received a lot of recent attention for their role in neural plasticity, a major mechanism leading to the development of chronic pain. However, changes in brain plasticit...
Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats [0.03%]
大鼠和小鼠痛觉过敏原发的时空及性别差异
Jamie K Moy,Thomas Szabo-Pardi,Dipti V Tillu et al.
Jamie K Moy et al.
Brain-derived neurotrophic factor (BDNF) signaling through its cognate receptor, TrkB, is a well-known promoter of synaptic plasticity at nociceptive synapses in the dorsal horn of the spinal cord. Existing evidence suggests that BDNF/TrkB ...
LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy [0.03%]
间歇性心理压力诱导的与纤维肌痛类似的疼痛及其共情中的LPA1受体作用机制研究
Hiroshi Ueda,Hiroyuki Neyama
Hiroshi Ueda
Treatment for fibromyalgia is an unmet medical need and its pathogenesis is still poorly understood. The present study demonstrated that intermittent psychological stress (IPS), or empathy causes generalized chronic abnormal pain with femal...
AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo [0.03%]
AMPK激活调节体外和体内小鼠感觉神经元中P体的动态变化
Candler Paige,Galo Mejia,Gregory Dussor et al.
Candler Paige et al.
Increased mRNA translation in sensory neurons following peripheral nerve injury contributes to the induction and maintenance of chronic neuropathic pain. Metformin, a common anti-diabetic drug and an activator of AMP-activated protein kinas...
Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain [0.03%]
CDK5介导的CRMP2磷酸化是外周神经病理性疼痛发生所必需且充分的条件
Aubin Moutal,Shizhen Luo,Tally M Largent-Milnes et al.
Aubin Moutal et al.
Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels. The dysregulation of trafficking of voltage-gated ion channels is...