Yenisel Cruz-Almeida,Pedro A Valdes-Hernandez,Yun Liang et al.
Yenisel Cruz-Almeida et al.
Trigeminal neuralgia (TN) is a complex orofacial neuropathic pain condition with limited understanding of underlying mechanisms and therapeutic options. Emerging evidence suggests the involvement of the brain in persons with TN including wi...
Unveiling the peripheral nerve hallmarks of chemotherapy-induced neuropathy: insights from paclitaxel treatment in a murine model [0.03%]
化疗诱导的外周神经病理性疼痛小鼠模型中化疗性神经病变的周围神经病理特征分析：紫杉醇治疗的影响与机制探讨
Maria Maiarù,Andrea Petrini,Federica De Angelis et al.
Maria Maiarù et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of anticancer drugs like paclitaxel, significantly reducing the quality of life for cancer patients. Paclitaxel-induced peripheral neuropathy (PIPN...
Individual differences in cognitive performance under pain linked to region-specific alpha power modulations [0.03%]
与疼痛相关的认知表现个体差异与区域特异性alpha功率调制有关
Francesca Storey,Mariya Prokhorenko,Michael L Keaser et al.
Francesca Storey et al.
Chronic pain is associated with reduced cognitive function, potentially due to a diversion of cognitive resources to processing pain. However, reduced cognitive function during pain is not always consistently evidenced, perhaps due to indiv...
The RNA-binding protein CELF4 is a negative regulator of sensory neuron excitability and mechanical and heat behavioral sensitivity [0.03%]
RNA结合蛋白CELF4是感觉神经元兴奋性及机械和热行为敏感性的负调节因子
Madison G Mueth,Peter Neufeld,Merilla Michael et al.
Madison G Mueth et al.
RNA-binding proteins (RBPs) regulate gene function by controlling RNA processing, transport, stability, and translation. Recent mechanistic and pre-clinical studies demonstrate that nociceptive sensitivity and plasticity are regulated by RN...
Neutrophil dynamics in surgical wounds - A novel role of interleukin-7 [0.03%]
外科手术伤口中性粒细胞动态变化——白介素-7的新角色
Annika Biesold,Philipp Burkard,Ankita Rawat et al.
Annika Biesold et al.
Postoperative pain and consequently chronic postsurgical pain remain a significant burden among patients. While neutrophilic granulocytes (neutrophils) are known to play a critical role in wound healing, their precise contribution to pain m...
Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain [0.03%]
人源化P2X4(scFv)在男性神经病理性疼痛模型鼠外周和中枢神经元的作用机制研究
Sachin Goyal,Ian Adams,Marena Montera et al.
Sachin Goyal et al.
Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an ATP-gated ion channel, is upregulated in sensory neurons and glial cells following nerve in...
The impact of nerve injury on the immune system across the lifespan is sexually dimorphic [0.03%]
神经损伤对生命全程免疫系统的性别二态性影响
Wen Bo S Zhou,Xiang Q Shi,Alain P Zhang et al.
Wen Bo S Zhou et al.
Although nerve injury-associated neuroinflammation contributes to neuropathic pain, the long-term impact of such injury on systemic homeostasis and its potential role in pain remains elusive. In this study, we aim to understand the systemic...
The effect of depression on the peak alpha frequency as a biomarker of pain sensitivity [0.03%]
抑郁症对峰值α频段频率作为疼痛敏感性生物标志物的影响研究
Mingge Shi,Luiza Bonfim Pacheco,Natalia Egorova-Brumley
Mingge Shi
Objective: To assess how Peak Alpha Frequency (PAF) as a neurophysiological biomarker of pain sensitivity is influenced by conditions often comorbid with chronic pain, e.g., depression, and how methodological differences ...
NGF stimulation alters the transcriptome and surface TrkB expression in axons of dorsal root ganglion neurons [0.03%]
NGF刺激改变DRG神经元轴突中转录组和表面TrkB表达
Maximilian Koch,Manas Kshirsagar,Ankita Rawat et al.
Maximilian Koch et al.
Nerve growth factor (NGF) is released after injury from macrophages and other cell types and induces an inflammatory response in neurons, characterized by local subcellular reactions and transcriptomic modulation. NGF-induced axonal transcr...
A non-toxic analgesic elicits cell-specific genomic and epigenomic modulation by targeting the PAG brain region [0.03%]
一种无毒的镇痛剂通过靶向PAG脑区诱导细胞特异性的基因组和表观基因组调节
Hernan A Bazan,Brian L Giles,Surjyadipta Bhattacharjee et al.
Hernan A Bazan et al.
Acetaminophen (ApAP) is widely used for pain management, but overuse or overdose leads to hepatotoxicity, making it the leading cause of acute liver failure globally. There is an urgent need for safer pain medications, as other non-opioid a...