Chronic pain after blast-induced traumatic brain injury in awake rats [0.03%]
清醒大鼠遭受爆炸诱发的创伤性脑损伤后的慢性疼痛现象
Olivia Uddin,Paige E Studlack,Saitu Parihar et al.
Olivia Uddin et al.
Explosive blast-induced traumatic brain injury (blast-TBI) in military personnel is a leading cause of injury and persistent neurological abnormalities, including chronic pain. We previously demonstrated that chronic pain after spinal cord ...
Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury [0.03%]
神经损伤后感觉神经元高兴奋性和慢性疼痛中的环核苷酸信号通路作用机制研究
Ze-Hua Li,Dong Cui,Cheng-Jie Qiu et al.
Ze-Hua Li et al.
The cyclic nucleotide signaling, including cAMP-PKA and cGMP-PKG pathways, has been well known to play critical roles in regulating cellular growth, metabolism and many other intracellular processes. In recent years, more and more studies h...
Sex differences in the expression of calcitonin gene-related peptide receptor components in the spinal trigeminal nucleus [0.03%]
calcitonin基因相关肽受体在三叉神经脊束核表达的性别差异研究
Yadong Ji,Alexandra Rizk,Pamela Voulalas et al.
Yadong Ji et al.
Background and purpose: Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology. CGRP acts primarily by activating a receptor composed of 3 proteins: calcitonin receptor-like receptor (C...
Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour [0.03%]
猫肉特蛋白S通过活化素受体2作用于感觉神经元并诱导瘙痒行为
Keshi Chung,Thomas Pitcher,Andrew D Grant et al.
Keshi Chung et al.
Chronic itch is a debilitating condition characterised by excessive scratching and is a symptom frequently reported in skin diseases such as atopic dermatitis. It has been proposed that release of the cysteine protease Cathepsin S (CatS) fr...
Alterations in brain neurocircuitry following treatment with the chemotherapeutic agent paclitaxel in rats [0.03%]
紫杉醇大鼠化疗后大脑神经回路的改变
Craig F Ferris,Sarah Nodine,Trent Pottala et al.
Craig F Ferris et al.
Human and animal studies suggest that both traumatic nerve injury and toxic challenge with chemotherapeutic agents involves the reorganization of neural circuits in the brain. However, there have been no prospective studies, human or animal...
In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain [0.03%]
寻找慢性口腔神经痛安慰剂止痛的大鼠模型
Titilola Akintola,Christina Tricou,Charles Raver et al.
Titilola Akintola et al.
All treatments are given in a context, suggesting that conditioning cues may significantly influence therapeutic outcomes. We tested the hypothesis that context affects placebo analgesia in rodents. To produce neuropathic pain in rats, we p...
Fibroblast growth factor homologous factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner [0.03%]
神经生长因子同源因子2（FGF-13）与DRG神经元中的Nav1.7相关并以其异构体依赖的方式改变其电流性质
Philip R Effraim,Jianying Huang,Angelika Lampert et al.
Philip R Effraim et al.
Fibroblast Growth Factor Homologous Factors (FHF) constitute a subfamily of FGF proteins with four prototypes (FHF1-4; also known as FGF11-14). FHF proteins have been shown to bind directly to the membrane-proximal segment of the C-terminus...
Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia [0.03%]
脑 reserve 阿片类药物对新生大鼠的双重影响：镇痛和痛觉过敏
Gong Kerui,Luc Jasmin
Gong Kerui
Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in n...
Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals [0.03%]
科拉属种子改善实验动物炎症和痛觉的甲醇提取物研究
Lawrence Dayo Adedayo,Alaba Olumide Ojo,Funmileyi Olubanjo Awobajo et al.
Lawrence Dayo Adedayo et al.
Methanol extract of Cola nitida (MECN) was evaluated for its anti-inflammatory and analgesic activities using rats and mice. Inflammatory activity of MECN was assessed by carrageenan-induced paw oedema while analgesic activity was evaluated...
The evaluation and brain representation of pleasant touch in chronic and subacute back pain [0.03%]
慢性期和亚急性期背痛患者对愉快触觉的评价及其大脑表征
F Nees,K Usai,M Löffler et al.
F Nees et al.
If touch is perceived as pleasant, it can counteract the experience of pain. However, its pain-inhibitory function might be disturbed in chronic pain and this could contribute to pain-related interference. We investigated the perception of ...