Lara W Crock,Megan T Baldridge
Lara W Crock
Complex regional pain syndrome (CRPS) is a debilitating neuroinflammatory condition of unknown etiology. Symptoms include excruciating pain and trophic changes in the limbs as defined by the Budapest criteria. The severity and functional re...
Stacie K Totsch,Keri M Kemp,Salvador A Lopez et al.
Stacie K Totsch et al.
Obesity is a global concern and affects millions of Americans who consume poor-quality diets. Diets directly affect the gut microbiota, which can have subsequent effects on inflammation and contribute to other chronic states. Previously we ...
Chronic inflammatory pain alters alcohol-regulated frontocortical signaling and associations between alcohol drinking and thermal sensitivity [0.03%]
慢性炎症疼痛改变酒精调节前额皮层信号及其与饮酒和热敏感性的关联
M Adrienne McGinn,Kimberly N Edwards,Scott Edwards
M Adrienne McGinn
Alcohol use disorder (AUD) is a chronic, relapsing psychiatric disorder that is characterized by the emergence of negative affective states. The transition from recreational, limited intake to uncontrolled, escalated intake is proposed to i...
Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies [0.03%]
关节痛的外周机制：提出利用大型动物进行体外研究的可能性
Sampurna Chakrabarti,Minji Ai,Frances M D Henson et al.
Sampurna Chakrabarti et al.
Pain arising from musculoskeletal disorders such as arthritis is one of the leading causes of disability. Whereas the past 20-years has seen an increase in targeted therapies for rheumatoid arthritis (RA), other arthritis conditions, especi...
Sascha R A Alles,Kimberly Gomez,Aubin Moutal et al.
Sascha R A Alles et al.
Large amino acid transporter 1 (LAT1), also known as SLC7A5, is an essential amino acid transporter that forms a heterodimeric complex with the glycoprotein cell-surface antigen heavy chain (4F2hc (CD98, SLC3A2)). Within nociceptive pathway...
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model [0.03%]
小鼠超敏性疼痛模型中基底外侧杏仁核非典型蛋白激酶C在性别差异中的作用
Daniela Baptista-de-Souza,Diana Tavares-Ferreira,Salim Megat et al.
Daniela Baptista-de-Souza et al.
Though sex differences in chronic pain have been consistently described in the literature, their underlying neural mechanisms are poorly understood. Previous work in humans has demonstrated that men and women differentially invoke distinct ...
CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior [0.03%]
CD3阳性T细胞对于并发性炎症痛和抑郁样行为的消退至关重要
Geoffroy Laumet,Jules D Edralin,Robert Dantzer et al.
Geoffroy Laumet et al.
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persisten...
Metformin protects from oxaliplatin induced peripheral neuropathy in rats [0.03%]
二甲双胍通过保护神经突触来预防奥沙利铂诱导的周围神经病变：在大鼠模型中的研究
N W Martinez,A Sánchez,P Diaz et al.
N W Martinez et al.
Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients having to reduc...
The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway [0.03%]
裸鼹鼠具有功能性嘌呤能疼痛通路，尽管其肽能疼痛通路不具功能
Brigitte M Browe,Abigail R Olsen,Cesar Ramirez et al.
Brigitte M Browe et al.
Naked mole-rats (Heterocephalus glaber) have adaptations within their pain pathway that are beneficial to survival in large colonies within poorly ventilated burrow systems, with lower O2 and higher CO2 ambient levels than ground-level envi...
Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons [0.03%]
环氧羟基和酮基衍生的亚油酸激活三叉神经元
Suzanne Doolen,Gregory S Keyes,Christopher E Ramsden
Suzanne Doolen
Endogenous lipid mediators are proposed to contribute to headache and facial pain by activating trigeminal neurons (TN). We recently identified 11-hydroxy-epoxide- and 11-keto-epoxide derivatives of linoleic acid (LA) that are present in hu...