Investigation of the neural basis of expectation-based analgesia in the human brainstem and spinal cord by means of functional magnetic resonance imaging [0.03%]
利用功能性磁共振研究人脑干和脊髓的预期镇痛的神经基础
P W Stroman,J M Powers,G Ioachim et al.
P W Stroman et al.
Purpose: The expected intensity of pain resulting from a noxious stimulus has been observed to have a strong influence on the pain that is perceived. The neural basis of pain reduction, as a result of expecting lower pain...
Diet, body weight and pain susceptibility - A systematic review of preclinical studies [0.03%]
饮食、体重与疼痛敏感性-系统综述动物实验研究
Carolina Marques Miranda,Mariana de Lima Campos,Hugo Leite-Almeida
Carolina Marques Miranda
Obesity has been associated with increased chronic pain susceptibility but causes are unclear. In this review, we systematize and analyze pain outcomes in rodent models of obesity as these can be important tools for mechanistic studies. Stu...
Christine West,Karen-Anne McVey Neufeld
Christine West
Visceral pain refers to pain arising from the internal organs and is distinctly different from the expression and mechanisms of somatic pain. Diseases and disorders with increased visceral pain are associated with significantly reduced qual...
Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens [0.03%]
儿童复杂区域疼痛综合征中的疼痛粘连性：伏隔核的作用
Andrew M Youssef,Ke Peng,Pearl Kijoo Kim et al.
Andrew M Youssef et al.
Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into ...
Kieran Rea,Siobhain M O&#x; Mahony,John F Cryan
Kieran Rea
Within the human gut, we each harbour a unique ecosystem represented by trillions of microbes that contribute to our health and wellbeing. These gut microbiota form part of a complex network termed the microbiota-gut-brain axis along with t...
Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection [0.03%]
三叉神经节直接投射至旁呼吸区复合体处理硬脑膜输入信号
Olivia Uddin,Michael Anderson,Jesse Smith et al.
Olivia Uddin et al.
Migraines cause significant disability and contribute heavily to healthcare costs. Irritation of the meninges' outermost layer (the dura mater), and trigeminal ganglion activation contribute to migraine initiation. Maladaptive changes in ce...
The gut-brain axis and beyond: Microbiome control of spinal cord injury pain in humans and rodents [0.03%]
脊髓损伤痛的肠道-大脑轴作用及其它：人和鼠微生物组控制研究
Courtney A Bannerman,Katya Douchant,Prameet M Sheth et al.
Courtney A Bannerman et al.
Spinal cord injury (SCI) is a devastating injury to the central nervous system in which 60 to 80% of patients experience chronic pain. Unfortunately, this pain is notoriously difficult to treat, with few effective options currently availabl...
Valentina N Lagomarsino,Aleksandar D Kostic,Isaac M Chiu
Valentina N Lagomarsino
Nociceptor sensory neurons innervate barrier tissues that are constantly exposed to microbial stimuli. During infection, pathogenic microorganisms can breach barrier surfaces and produce pain by directly activating nociceptors. Microorganis...
Control of synaptic transmission and neuronal excitability in the parabrachial nucleus [0.03%]
外侧parabrachial核突触传递和神经元兴奋性的调控机制研究
Nathan Cramer,Gleice Silva-Cardoso,Radi Masri et al.
Nathan Cramer et al.
The parabrachial nucleus (PB) is a hub for aversive behaviors, including those related to pain. We have shown that the expression of chronic pain is causally related to amplified activity of PB neurons, and to changes in synaptic inhibition...
Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine [0.03%]
从多能干细胞衍生的人类感觉神经元用于疾病建模和个性化医疗
Angelika Lampert,David L Bennett,Lucy A McDermott et al.
Angelika Lampert et al.
In this concise Mini-Review we will summarize ongoing developments of new techniques to study physiology and pathophysiology of the peripheral sensory nervous system in human stem cell derived models. We will focus on recent developments of...