Ai-Ling Li,Jonathon D Crystal,Yvonne Y Lai et al.
Ai-Ling Li et al.
Childhood acute lymphoblastic leukemia (ALL) is a significant clinical problem that can be effectively treated with vincristine, a vinca alkaloid-based chemotherapeutic agent. However, nearly all children receiving vincristine treatment dev...
Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation [0.03%]
淀粉样蛋白沉积小鼠模型中的认知衰退和躯体感觉处理模式
Olivia Uddin,Keiko Arakawa,Charles Raver et al.
Olivia Uddin et al.
Pain and cognitive decline increase with age. In particular, there is a troubling relationship between dementia and pain, with some studies showing higher prevalence and inadequate treatment of pain in this population. Alzheimer's disease (...
Physiological properties of pain-modulating neurons in rostral ventromedial medulla in female rats, and responses to opioid administration [0.03%]
雌性大鼠头端腹侧嘴侧中脑的痛觉调节神经元的生理特性以及对阿片类药物给药的反应
Gwen Hryciw,Caitlynn C De Preter,Jennifer Wong et al.
Gwen Hryciw et al.
Functional pain disorders disproportionately impact females, but most pain research in animals has been conducted in males. While there are anatomical and pharmacological sexual dimorphisms in brainstem pain-modulation circuits, the physiol...
Sensory-specific peripheral nerve pathology in a rat model of Fabry disease [0.03%]
法布里病大鼠模型中的感觉特异性周围神经病理变化
Tyler B Waltz,Anthony J Burand Jr,Katelyn E Sadler et al.
Tyler B Waltz et al.
Fabry disease (FD) causes life-long pain, the mechanisms of which are unclear. Patients with FD have chronic pain that mirrors symptoms of other painful peripheral neuropathies. However, it is unclear what underlying damage occurs in FD per...
Estrogen exacerbates the nociceptive effects of peripheral serotonin on rat trigeminal sensory neurons [0.03%]
雌激素通过外周血清素加剧大鼠三叉神经感觉神经元痛觉效应
Sukhbir Kaur,Hanna McDonald,Sirima Tongkhuya et al.
Sukhbir Kaur et al.
Orofacial pain disorders involving trigeminal sensory neurons disproportionately affect women and can be modulated by hormones, especially estrogen (E2). Proinflammatory mediators, like serotonin (5HT), can act on sensory neurons expressing...
Pain after upper limb surgery under peripheral nerve block is associated with gut microbiome composition and diversity [0.03%]
外周神经阻滞上肢手术后疼痛与肠道微生物组构成和多样性相关
David Brenner,Paul Cherry,Tim Switzer et al.
David Brenner et al.
Gut microbiota play a role in certain pain states. Hence, these microbiota also influence somatic pain. We aimed to determine if there was an association between gut microbiota (composition and diversity) and postoperative pain. Patients (n...
Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction [0.03%]
靶向胆囊收缩素-B受体的单链抗体片段用于镇痛
K N Westlund,M A Montera,A E Goins et al.
K N Westlund et al.
The cholecystokinin B receptor and its neuropeptide ligand are upregulated in chronic neuropathic pain models. Single-chain Fragment variable antibodies were generated as preferred non-opioid targeting therapy blocking the cholecystokinin B...
David Brenner,George D Shorten,Siobhain M O&#x;Mahony
David Brenner
In excess of 300 million surgical procedures are undertaken worldwide each year. Despite recognition of the prevalence of postoperative pain, and improvements in pain management techniques, poorly controlled postoperative pain remains a maj...
Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization [0.03%]
瑞芬太尼诱导的μ-阿片受体胞吞过程中ANKS1A辅助的 Annexin A2 对 μ-阿片受体再循环的作用
Idy H T Ho,Lhotse H L Ng,Xiaojie Cheng et al.
Idy H T Ho et al.
•ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization.•ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure. ...
Heterogeneity in patterns of pain development after nerve injury in rats and the influence of sex [0.03%]
大鼠神经损伤后疼痛的发展模式及其性别影响的异质性
Katherine Sherman,Victoria Woyach,James C Eisenach et al.
Katherine Sherman et al.
The genesis of neuropathic pain is complex, as sensory abnormalities may differ between patients with different or similar etiologies, suggesting mechanistic heterogeneity, a concept that is largely unexplored. Yet, data are usually grouped...