Soo-Min Jung,Lee Peyton,Hesham Essa et al.
Soo-Min Jung et al.
Physical and emotional pain deteriorates the quality of well-being. Also, numerous non-invasive and invasive treatments for diagnosed diseases such as cancer medications and surgical procedures cause various types of pain. Despite the multi...
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways [0.03%]
慢性腰背痛的黑人和白人个体中差异性的DNA甲基化富集不同的基因组通路
Edwin N Aroke,Pamela Jackson,Lingsong Meng et al.
Edwin N Aroke et al.
Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation ...
Intrinsic network connectivity reflects the cyclic trajectory of migraine attacks [0.03%]
内在网络连接性反映了偏头痛发作的周期轨迹
Anne Stankewitz,Enrico Schulz
Anne Stankewitz
Background: Episodic migraine is considered to be cyclic in nature, triggered by the hypothalamus. To assess the natural trajectory of intrinsic networks over an entire migraine cycle, we designed a longitudinal intra-ind...
Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment [0.03%]
受压眶下神经支配三叉神经节神经元轴突信号传导中电压门控钠通道的作用研究
Yatendra Mulpuri,Toru Yamamoto,Ichiro Nishimura et al.
Yatendra Mulpuri et al.
Chronic pain arising from peripheral nerve injuries represents a significant clinical challenge because even the most efficacious anticonvulsant drug treatments are limited by their side effects profile. We investigated pain behavior, chang...
Federico Iseppon,John E Linley,John N Wood
Federico Iseppon
Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems. In recent decades, advances in the investigation of these networks, as we...
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain [0.03%]
一种小分子通过抑制CRMP2-Ubc9相互作用靶向NaV1.7减轻和预防异环磷酰胺诱导的神经痛小鼠模型中的疼痛慢性化
Kathryn Braden,Harrison J Stratton,Daniela Salvemini et al.
Kathryn Braden et al.
Treatment with anti-neoplastic agents can lead to the development of chemotherapy induced peripheral neuropathy (CIPN), which is long lasting and often refractory to treatment. This neuropathic pain develops along dermatomes innervated by p...
Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy [0.03%]
钙敏三磷酸腺苷环化酶AC1和AC8在坐骨神经损伤模型小鼠前扣带回皮层的表达及功能研究
Stephanie Shiers,Hajira Elahi,Stephanie Hennen et al.
Stephanie Shiers et al.
The anterior cingulate cortex (ACC) is a critical region of the brain for the emotional and affective components of pain in rodents and humans. Hyperactivity in this region has been observed in neuropathic pain states in both patients and a...
Cellular models of pain: New technologies and their potential to progress preclinical research [0.03%]
疼痛的细胞模型：新技术及其推进基础医学研究的潜力
Lina Chrysostomidou,Andrew H Cooper,Greg A Weir
Lina Chrysostomidou
In vitro models fill a vital niche in preclinical pain research, allowing detailed study of molecular pathways, and in the case of humanised systems, providing a translational bridge between in vivo animal models and human patients. Signifi...
Thermal hyperalgesia and dynamic weight bearing share similar recovery dynamics in a sciatic nerve entrapment injury model [0.03%]
坐骨神经卡压损伤模型中热痛过敏和动态负重的恢复规律相似
Garrett D Sheehan,Molly K Martin,Violet A Young et al.
Garrett D Sheehan et al.
Chronic constriction injuries (CCI) of the sciatic nerve are widely used nerve entrapment animal models of neuropathic pain. Two common pain behaviors observed following CCI are thermal hyperalgesia and mechanical allodynia, measured by the...
Input-dependent synaptic suppression by pregabalin in the central amygdala in male mice with inflammatory pain [0.03%]
戊己酸钠在雄性慢性炎症疼痛小鼠中枢杏仁核中的突触抑制作用依赖于刺激类型
Sumii Yamamoto,Yukari Takahashi,Fusao Kato
Sumii Yamamoto
Pregabalin (PGB) is a synthetic amino acid compound most widely prescribed for chronic peripheral and central neuropathic pain. PGB is a ligand for the α2δ1 subunit of voltage-dependent calcium channels, and its binding reduces neurotrans...