Comprehensive phenotyping of cutaneous afferents reveals early-onset alterations in nociceptor response properties, release of CGRP, and hindpaw edema following spinal cord injury [0.03%]
全面表征皮肤afferents发现脊髓损伤后痛觉感受器反应特性早期改变、CGRP释放和小腿水肿
Olivia C Eller,Rena N Stair,Christopher Neal et al.
Olivia C Eller et al.
Spinal cord injury (SCI) is a complex syndrome that has profound effects on patient well-being, including the development of medically-resistant chronic pain. The mechanisms underlying SCI pain have been the subject of thorough investigatio...
Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling [0.03%]
低剂量干扰素-γ通过外周白细胞介素-10和转化生长因子β-1信号逆转慢性偏头痛相关的感觉过敏现象
Zhaohua Guo,Jintao Zhang,Xuemei Liu et al.
Zhaohua Guo et al.
Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion and activation of peripheral regulatory T cells ...
Percutaneous electric nerve field stimulation alters cortical thickness in a pilot study of veterans with fibromyalgia [0.03%]
经皮电神经场刺激在纤维肌痛退伍军人中的概念验证研究对皮质厚度的影响
Anna Woodbury,Lisa C Krishnamurthy,Anastasia Bohsali et al.
Anna Woodbury et al.
Objective: To evaluate changes in cortical thickness and right posterior insula (r-pIns) gamma-aminobutyric acid (GABA) concentrations in veterans with fibromyalgia treated with auricular percutaneous electric nerve field...
Interplay between exosomes and autophagy machinery in pain management: State of the art [0.03%]
外泌体与自噬在疼痛管理中的相互作用：最新研究进展
Hamidreza Morteza Bagi,Sajjad Ahmadi,Faezeh Tarighat et al.
Hamidreza Morteza Bagi et al.
Despite recent progress regarding inexpensive medical approaches, many individuals suffer from moderate to severe pain globally. The discovery and advent of exosomes, as biological nano-sized vesicles, has revolutionized current knowledge a...
Wanakorn Rattanawong,Alan Rapoport,Anan Srikiatkhachorn
Wanakorn Rattanawong
Chronic migraine is one of the most devastating headache disorders. The estimated prevalence is 1.4-2.2% in the population. The factors which may predispose to the process of migraine progression include high frequency of migraine attacks, ...
Justin E LaVigne,Sascha R A Alles
Justin E LaVigne
The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this tar...
Simone Carneiro-Nascimento,Dan Levy
Simone Carneiro-Nascimento
Migraine results in an enormous burden on individuals and societies due to its high prevalence, significant disability, and considerable economic costs. Current treatment options for migraine remain inadequate, and the development of novel ...
Joshua Crawford,Sufang Liu,Feng Tao
Joshua Crawford
Migraine is a leading cause of disability among the adult population and is a significant burden on the economies of the world. Studies into the underlying causes of migraine have spanned centuries but its underlying mechanisms are still no...
Analysis of the DNA methylation pattern of the promoter region of calcitonin gene-related peptide 1 gene in patients with episodic migraine: An exploratory case-control study [0.03%]
偏头痛患者降钙素基因相关肽1基因启动子区DNA甲基化模式分析：一项探索性病例对照研究
Elisa Rubino,Silvia Boschi,Elisa Giorgio et al.
Elisa Rubino et al.
Recent studies suggested that epigenetic mechanisms, including DNA methylation, may be involved in migraine pathogenesis. The calcitonin gene-related peptide (CGRP), encoded by calcitonin gene-related peptide 1 (CALCA) gene, plays a key rol...
Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice [0.03%]
辣椒素通过抑制背根神经节中IL-31RA的表达部分缓解雄性小鼠痒觉
Iwao Arai,Minoru Tsuji,Hiroshi Takeda et al.
Iwao Arai et al.
To elucidate the mechanisms underlying the antipruritic effect of capsaicin, we investigated how topical application of capsaicin (0.01, 0.1 and 1.0% w/v) affects spontaneous scratching in NC/Nga mice, inerleukin-31 (IL-31) induced in BALB/...