Simona Nikolova,Todd J Schwedt
Simona Nikolova
This review summarizes major findings and recent advances in magnetic resonance spectroscopy (MRS) of migraine. A multi database search of PubMed, EMBASE, and Web of Science was performed with variations of magnetic resonance spectroscopy a...
Sex-distinct microglial activation and myeloid cell infiltration in the spinal cord after painful peripheral injury [0.03%]
疼痛外周损伤后脊髓中性别差异的的小胶质细胞活化和骨髓细胞渗入
Nolan A Huck,Lauren J Donovan,Huaishuang Shen et al.
Nolan A Huck et al.
Chronic pain is a common and often debilitating problem that affects 100 million Americans. A better understanding of pain's molecular mechanisms is necessary for developing safe and effective therapeutics. Microglial activation has been im...
Anandamide in the dorsal periaqueductal gray inhibits sensory input without a correlation to sympathoexcitation [0.03%]
中脑导水管周围灰质背侧部的阿南达胺抑制感觉传入而不与交感神经元激活相关
Christopher J Roberts,Francis A Hopp,Quinn H Hogan et al.
Christopher J Roberts et al.
There is growing literature supporting cannabinoids as a potential therapeutic for pain conditions. The development of chronic pain has been associated with reduced concentrations of the endogenous cannabinoid anandamide (AEA) in the midbra...
Comparison of Pain-Like behaviors in two surgical incision animal models in C57BL/6J mice [0.03%]
C57BL/6J小鼠两种手术切口动物模型的痛觉行为比较研究
Esad Ulker,Martial Caillaud,Eda Koseli et al.
Esad Ulker et al.
Background: Management of pain post-surgery is crucial for tissue healing in both veterinary and human medicine. Overuse of some analgesics such as opioids may lead to addictions and worsen pain syndromes (opioid-induced ...
Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons [0.03%]
大鼠迷走神经节神经元中NaV1.7活性和运输的细胞特异性调节
Santiago I Loya-López,Paz Duran,Dongzhi Ran et al.
Santiago I Loya-López et al.
The voltage-gated sodium NaV1.7 channel sets the threshold for electrogenesis. Mutations in the gene encoding human NaV1.7 (SCN9A) cause painful neuropathies or pain insensitivity. In dorsal root ganglion (DRG) neurons, activity and traffic...
Enrichment of genomic pathways based on differential DNA methylation profiles associated with knee osteoarthritis pain [0.03%]
基于与膝骨关节炎疼痛相关的差异DNA甲基化谱的基因组途径的富集分析
Soamy Montesino-Goicolea,Lingsong Meng,Asha Rani et al.
Soamy Montesino-Goicolea et al.
Our study aimed to identify differentially methylated regions (i.e., genomic region where multiple adjacent CpG sites show differential methylation) and their enriched genomic pathways associated with knee osteoarthritis pain (KOA). We recr...
The neurobiology of social stress resulting from Racism: Implications for pain disparities among racialized minorities [0.03%]
种族歧视所致社会压力的神经生物学机制及其对少数族裔疼痛差异的影响
Joanna M Hobson,Myles D Moody,Robert E Sorge et al.
Joanna M Hobson et al.
Extant literature posits that humans experience two types of threat: physical threat and social threat. While describing pain as "physical" or "social" can be helpful for understanding pain origins (i.e., broken bone versus lost relationshi...
Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine [0.03%]
慢性偏头痛患者中动态有效连接模式编码痛觉波动的规律研究
Iege Bassez,Frederik Van de Steen,Sophie Hackl et al.
Iege Bassez et al.
Chronic migraine is characterised by persistent headaches for >15 days per month; the intensity of the pain is fluctuating over time. Here, we explored the dynamic interplay of connectivity patterns between regions known to be related to pa...
Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia [0.03%]
δ型阿片受体通过周围表达Nav1.8的神经元在偏头痛及阿片类物质引起痛觉过敏模型中起部分调节作用
Zachariah Bertels,Isaac J Dripps,Pal Shah et al.
Zachariah Bertels et al.
Migraine is one of the most common pain disorders and causes disability in millions of people every year. Delta opioid receptors (DOR) have been identified as a novel therapeutic target for migraine and other headache disorders. DORs are pr...
Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice [0.03%]
刺激小脑中核CGRP阳性神经元诱导小鼠产生对光和触觉的敏感性
Mengya Wang,William C Castonguay,Thomas L Duong et al.
Mengya Wang et al.
Calcitonin gene-related peptide (CGRP) is considered a major player in migraine pathophysiology. However, the location and mechanisms of CGRP actions in migraine are not clearly elucidated. One important question yet to be answered is: Does...