Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool [0.03%]
利用SCN10A启动子特异性病毒载体工具调节人类伤害感受器的活性
Stephanie Mouchbahani-Constance,Camille Lagard,Justine Schweizer et al.
Stephanie Mouchbahani-Constance et al.
Despite the high prevalence of chronic pain as a disease in our society, there is a lack of effective treatment options for patients living with this condition. Gene therapies using recombinant AAVs are a direct method to selectively expres...
Regulation by noncoding RNAs of local translation, injury responses, and pain in the peripheral nervous system [0.03%]
非编码RNA通过调节局部翻译、损伤反应和外周神经系统的疼痛来发挥作用
Xinbei Li,Daniel S Jin,Sreenivas Eadara et al.
Xinbei Li et al.
Neuropathic pain is a chronic condition arising from damage to somatosensory pathways that results in pathological hypersensitivity. Persistent pain can be viewed as a consequence of maladaptive plasticity which, like most enduring forms of...
The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis [0.03%]
膝骨关节炎患者急性运动的自主和伤害性反应受损
Neil R Bossenger,Gwyn N Lewis,David A Rice et al.
Neil R Bossenger et al.
Objectives: An acute bout of exercise typically leads to short term exercise induced hypoalgesia (EIH), but this response is more variable in many chronic pain populations, including knee osteoarthritis (OA) and fibromyal...
Intramuscular injection of nerve growth factor as a model of temporomandibular disorder: nature, time-course, and sex differences characterising the pain experience [0.03%]
神经生长因子肌肉注射作为颞下颌关节紊乱的模型：疼痛反应的性质、时间过程和性别差异特征研究
S M Schabrun,E Si,S K Millard et al.
S M Schabrun et al.
Background: Temporomandibular disorder (TMD) is a common condition that frequently transitions to chronic symptoms. Experimental pain models that mimic the symptoms of clinical TMD may be useful in understanding the mecha...
Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain [0.03%]
白桦酸类似物通过抑制N型和T型电压门控钙通道减轻神经损伤相关的神经病理性疼痛和甲醛引起的疼痛模型
Aida Calderon-Rivera,Kimberly Gomez,Santiago Loya-López et al.
Aida Calderon-Rivera et al.
Over the past three decades, there has been a significant growth in the use of natural products, with approximately 80% of individuals using them for some aspect of primary healthcare. Our laboratories have identified and studied natural co...
Anthony J Burand Jr,Tyler B Waltz,Anna D Manis et al.
Anthony J Burand Jr et al.
HomeCageScan (HCS) is an automated behavioral scoring system that can be used to classify and quantify rodent behaviors in the home cage. Although HCS has been used for a number of inducible models of severe pain, little has been done to te...
The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia [0.03%]
为期15周的运动干预对纤维肌痛疼痛调节的影响：皮层-尾状核-枕叶网络中与疼痛相关的处理增加，但运动诱导的镇痛并未改善
Monika Löfgren,Angelica Sandström,Indre Bileviciute-Ljungar et al.
Monika Löfgren et al.
Dysfunctional top-down pain modulation is a hallmark of fibromyalgia (FM) and physical exercise is a cornerstone in FM treatment. The aim of this study was to explore the effects of a 15-week intervention of strengthening exercises, twice p...
Prostaglandin-E2 levels over the course of glyceryl trinitrate provoked migraine attacks [0.03%]
硝酸甘油诱发偏头痛发作过程中前列腺素E2水平的变化
Aster V E Harder,Gerrit L J Onderwater,Robin M van Dongen et al.
Aster V E Harder et al.
Administration of glyceryl trinitrate (GTN), a donor of nitric oxide, can induce migraine-like attacks in subjects with migraine. Provocation with GTN typically follows a biphasic pattern; it induces immediate headache in subjects with migr...
Brainstem pain-modulating neurons are sensitized to visual light in persistent inflammation [0.03%]
脑干痛觉调节神经元在持续炎症中对视觉光敏感化
Gwen Hryciw,Jennifer Wong,Mary M Heinricher
Gwen Hryciw
Many individuals with chronic pain report abnormal sensitivity to visual light, referred to as "photosensitivity" or "photophobia," yet how processing of light and nociceptive information come together remains a puzzle. Pain-modulating neur...
Stress-induced hyperalgesia instead of analgesia in patients with chronic musculoskeletal pain [0.03%]
慢性肌肉骨骼疼痛患者中应激诱发的异常痛觉敏感而非镇痛反应
Martin Löffler,Pia Schneider,Sigrid Schuh-Hofer et al.
Martin Löffler et al.
Many individuals with chronic musculoskeletal pain (CMP) show impairments in their pain-modulatory capacity. Although stress plays an important role in chronic pain, it is not known if stress-induced analgesia (SIA) is affected in patients ...