Citrobacter rodentium Infection Inhibits Colonic P-glycoprotein Expression [0.03%]
Citrobacter rodentium 感染抑制结肠P-糖蛋白的表达
Mitul Patel,Anoop Kumar,Dulari Jayawardena et al.
Mitul Patel et al.
P-glycoprotein (Pgp/MDR1) serves as a biological barrier that protects intestinal epithelial cells (IECs) by transporting out xenobiotics and bacterial toxins. Decreased Pgp function and expression has been seen in mouse models of inflammat...
Phylogenomic proximity and comparative proteomic analysis of SARS-CoV-2 [0.03%]
SARS-CoV-2的系统基因组接近度及比较蛋白质组学分析
R Prathiviraj,George Seghal Kiran,Joseph Selvin
R Prathiviraj
The coronavirus disease (COVID-19) belongs to the family Severe Acute Respiratory Syndrome (SARS-CoV). It can be more severe for some persons and can lead to pneumonia or breathing difficulties resulting in the death of immune-compromised p...
mTOR inhibition and p53 activation, microRNAs: The possible therapy against pandemic COVID-19 [0.03%]
mTOR抑制和p53激活，microRNA：对抗大流行COVID-19的可能疗法
Mekala Janaki Ramaiah
Mekala Janaki Ramaiah
mTOR is a serine-threonine kinase and participates in cell proliferation, cellular metabolism was found to be activated during Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection and replication. During viral replic...
Novel SARS-CoV-2/COVID-19: Origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis [0.03%]
新型冠状病毒（SARS-CoV-2）的来源、发病机制、基因和基因变异、免疫反应及进化分析
Yasmeen Junejo,Mehmet Ozaslan,Muhamad Safdar et al.
Yasmeen Junejo et al.
In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for d...
COVID-19 target: A specific target for novel coronavirus detection [0.03%]
2019新型冠状病毒检测靶标推荐报告之特定靶标推荐报告
Reza Kamali Kakhki,Mohammad Kamali Kakhki,Alireza Neshani
Reza Kamali Kakhki
An ongoing outbreak of pneumonia associated with a novel coronavirus has been reported worldwide and become a global health problem; hence, the diagnosis and differentiation of this virus from other types of coronavirus is essential to cont...
Total Protein Staining is Superior to Classical or Tissue-Specific Protein Staining for Standardization of Protein Biomarkers in Heterogeneous Tissue Samples [0.03%]
全蛋白染色比经典或组织特异性蛋白染色更适用于异质性组织样本中蛋白质生物标志物的标准化
Jacob W Bettencourt,Alex R McLaury,Afton K Limberg et al.
Jacob W Bettencourt et al.
Protein detection techniques such as western blotting and ELISA rely on housekeeping proteins as standards for sample normalization. However, clinical or animal tissue specimens are heterogeneous due to presence of contaminating cell types ...
Pathogenicity-associated protein domains: The fiercely-conserved evolutionary signatures [0.03%]
与致病性相关的蛋白质结构域：激烈的保守的进化标志
Seema Patel
Seema Patel
Proteins have highly conserved domains that determine their functionality. Out of the thousands of domains discovered so far across all living forms, some of the predominant clinically-relevant domains include IENR1, HNHc, HELICc, Pro-kuma_...
Increased frequency of CD4+CD25high CD127low / - regulatory T cells in patients with multiple sclerosis [0.03%]
多发性硬化患者中CD4+CD25highCD127low/-调节T细胞增多
Maryam Khosravi,Nastaran Majdinasab,Afshin Amari et al.
Maryam Khosravi et al.
Background: Multiple sclerosis (MS), one of the most common diseases of the central nervous system (CNS), is characterized by demyelination and chronic inflammation of the CNS. Failure of immune tolerance and induced auto...
Rozhgar A Khailany,Muhamad Safdar,Mehmet Ozaslan
Rozhgar A Khailany
A new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with human to human transmission and extreme human sickness has been as of late announced from the city of Wuhan in China. Our objectives were to mutation analysi...
Systems biology approach: Panacea for unravelling host-virus interactions and dynamics of vaccine induced immune response [0.03%]
系统生物学方法：解开宿主病毒互作及解析疫苗诱导的免疫反应动力学的万能药
Sajad Ahmad Wani,Amit Ranjan Sahu,Shikha Saxena et al.
Sajad Ahmad Wani et al.
Systems biology is an interdisciplinary research field in life sciences, which involves a comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. For the past 50 years the d...