Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic [0.03%]
新型冠状病毒肺炎疫情期间SARS-CoV-2ORF8的突变分析
Ahmad Alkhansa,Ghayas Lakkis,Loubna El Zein
Ahmad Alkhansa
SARS-CoV-2, the causal agent of COVID 19, is a new human pathogen that appeared in Wuhan, late December 2019. SARS-CoV-2 is a positive sense RNA virus, having four structural and six accessory proteins including that encoded by ORF8 gene kn...
Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways [0.03%]
计算预测的SARS-CoV-2编码的小干扰RNA靶向NFκB、JAK / STAT和TGFβ信号通路
Merve Nur Aydemir,Habes Bilal Aydemir,Ertan Mahir Korkmaz et al.
Merve Nur Aydemir et al.
Recently an outbreak that emerged in Wuhan, China in December 2019, spread to the whole world in a short time and killed >1,410,000 people. It was determined that a new type of beta coronavirus called severe acute respiratory disease corona...
M Shaminur Rahman,M Nazmul Hoque,M Rafiul Islam et al.
M Shaminur Rahman et al.
The ongoing mutations in the structural proteins of SARS-CoV-2 are the major impediment for prevention and control of the COVID-19 disease. Presently we focused on evolution of the envelope (E) protein, one of the most enigmatic and less st...
Comprehensive in silico identification of impacts of ACE2 SNPs on COVID-19 susceptibility in different populations [0.03%]
全面计算识别ACE2变异对不同人群新冠肺炎易感性的影响
Alireza Paniri,Mohammad Mahdi Hosseini,Mojtaba Moballegh-Eslam et al.
Alireza Paniri et al.
The COVID-19 pandemic emerges a reminder that wide spectrum discrepancy in response to SARS-CoV-2 infection and antiviral drugs among different populations might be due to their different ACE2 SNPs and/or miRNAs profile. ACE2 is the major c...
Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients [0.03%]
冠状病毒微阵列数据集的基因表达谱分析以识别COVID-19患者中的关键靶点
Priyanka Ramesh,Shanthi Veerappapillai,Ramanathan Karuppasamy
Priyanka Ramesh
The current outbreak of coronavirus disease (COVID-19) has been affecting millions of people and has caused devastating mortality worldwide. Moreover, it is to be noted that cytokine storm has become an important cause for the rising mortal...
Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh [0.03%]
基因组探索揭示了孟加拉国引起严重急性呼吸系统综合症冠状病毒2的多重起源及潜在简约建树信息位点
Otun Saha,Md Shahadat Hossain,Md Mizanur Rahaman
Otun Saha
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of beta coronavirus that has spread worldwide within a short period of time and has been responsible for the current COVID-19 pandemic. This novel virus shows high...
Determination of COVID-19 prevalence with regards to age range of patients referring to the hospitals located in western Tehran, Iran [0.03%]
关于伊朗德黑兰西部医院就诊患者的年龄范围的COVID-19患病率的确定
Hamidreza Kalantari,Aida Haji Hossein Tabrizi,Fatemeh Foroohi
Hamidreza Kalantari
We decided to examine suspected samples of pneumonia outbreak caused by the new coronavirus SARS-CoV-2 and provide information about the mortality rate due to this infection in different age groups in Iran. In this descriptive-cross-section...
Identification of twenty-five mutations in surface glycoprotein (Spike) of SARS-CoV-2 among Indian isolates and their impact on protein dynamics [0.03%]
印度分离株中SARS-CoV-2表面糖蛋白(Spike)的二十五种突变及其对蛋白质动力学的影响识别
Gyanendra Bahadur Chand,Atanu Banerjee,Gajendra Kumar Azad
Gyanendra Bahadur Chand
SARS-CoV-2, the causative agent of the COVID-19 pandemic, is an RNA virus that has inherent high rate of mutation. Due to the mutations, the virus evolves at a rapid pace that helps them to survive better inside the host. One of the hotspot...
Genetic characterization of structural and open reading Fram-8 proteins of SARS-CoV-2 isolates from different countries [0.03%]
不同国家的SARS-CoV-2分离株结构性和开放阅读框蛋白质的基因特征分析
Abdullah Shah,Farooq Rashid,Abdul Aziz et al.
Abdullah Shah et al.
Since December 2019, a severe pandemic of pneumonia, COVID-19 associated with a novel coronavirus (SARS-CoV-2), have emerged in Wuhan, China and spreading throughout the world. As RNA viruses have a high mutation rate therefore we wanted to...
In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors [0.03%]
SARS-CoV-2 Nsp13解旋酶和Nsp14的计算机辅助结构建模以及FDA批准的抗病毒药物的再利用作为双重抑制剂
Arun Bahadur Gurung
Arun Bahadur Gurung
The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. SARS-CoV-2 ...