Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica [0.03%]
关于新冠病毒刺突蛋白T1177I突变和在哥斯达黎加流行的谱系B.1.1.389的见解
Jose Arturo Molina-Mora
Jose Arturo Molina-Mora
Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the spike (S:T1117I) wa...
Highlight of potential impact of new viral genotypes of SARS-CoV-2 on vaccines and anti-viral therapeutics [0.03%]
新的SARS-CoV-2病毒基因型对疫苗和抗病毒药物的影响展望
Abozar Ghorbani,Samira Samarfard,Maziar Jajarmi et al.
Abozar Ghorbani et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the coronavirus disease (COVID-19) pandemic, has infected millions of people globally. Genetic variation and selective pressures lead to the accumulation of s...
RNAi-mediated siRNA sequences to combat the COVID-19 pandemic with the inhibition of SARS-CoV2 [0.03%]
用于抑制SARS-CoV-2的对抗COVID-19大流行的RNA干扰介导的小干扰 RNA序列
Khandakar A S M Saadat
Khandakar A S M Saadat
The outbreak of the COVID-19 pandemic has cost five million lives to date, and was caused by a positive-sense RNA virus named SARS-CoV2. The lack of drugs specific to SARS-CoV2, leads us to search for an effective and specific therapeutic a...
Serum levels of vitamin D and immune system function in patients with COVID-19 admitted to intensive care unit [0.03%]
重症监护病房中新冠肺炎患者的维生素D水平与免疫系统功能关系研究
Mohammad Sadegh Soltani-Zangbar,Ata Mahmoodpoor,Sanam Dolati et al.
Mohammad Sadegh Soltani-Zangbar et al.
Objective: Vitamin D is believed to affect the functionality of the immune system for the prevention of coronavirus disease. To investigate the role of this vitamin against the Coronavirus, this study analyzed the serum l...
The impact of lymphoid memory cells in different ages of COVID-19 patients [0.03%]
不同年龄段COVID-19患者淋巴细胞记忆细胞的建立及意义分析
Mozhdeh Jafari,Hanieh Kolahdooz,Mahmoud Mahmoudi et al.
Mozhdeh Jafari et al.
Coronaviruses are highly pathogenic and transmissible viruses. The SARS-CoV-2 virus that emerged in December 2019 is increasingly recognized as a serious, worldwide public health concern. Respiratory infections and the hyper-inflammatory re...
Investigation of CYP2E1 and Caspase-3 Gene Expressions in COVID-19 patients [0.03%]
COVID-19患者中CYP2E1和Caspase-3基因表达的研究
S Karabulut Uzuncakmak,E Dirican,M E Naldan et al.
S Karabulut Uzuncakmak et al.
Background: COVID-19 pandemic spread around the world like an infectious disease that presents waved effects on patients. Some patients needed ICU and respiratory support. Some patients only had flu-like symptoms. Cytokin...
Global data analysis and risk factors associated with morbidity and mortality of COVID-19 [0.03%]
全球数据分析及COVID-19致病致死风险因素分析
Sina Salajegheh Tazerji,Fatemeh Shahabinejad,Mahya Tokasi et al.
Sina Salajegheh Tazerji et al.
This review was focused on global data analysis and risk factors associated with morbidity and mortality of coronavirus disease 2019 from different countries, including Bangladesh, Brazil, China, Central Eastern Europe, Egypt, India, Iran, ...
Enhanced endocytosis elevated virulence and severity of SARS-CoV-2 due to hyperglycemia in type 2 diabetic patients [0.03%]
高血糖通过增强内吞作用提高2型糖尿病患者感染SARS-CoV-2的致病性和严重性
Kannan Subbaram,P Shaik Syed Ali,Sheeza Ali
Kannan Subbaram
Diabetes mellitus is a metabolic disease that causes hyperglycemia. In COVID-19 patients the severity of the disease depends on myriad factors but diabetes mellitus is the most important comorbidity. The current review was conducted to inve...
Evaluation of biochemical characteristics of 183 COVID-19 patients: A retrospective study [0.03%]
183例COVID-19患者的生化特征评价：一项回顾性研究
Seyed Mostafa Mir,Alireza Tahamtan,Hadi Razavi Nikoo et al.
Seyed Mostafa Mir et al.
Introduction and aim: Coronavirus disease 2019 (COVID-19), with a high mortality rate, has caught the eyes of researchers worldwide and placed a heavy burden on the health care system. Accordingly, this study aimed to eva...
Binder design for targeting SARS-CoV-2 spike protein: An in silico perspective [0.03%]
针对SARS-CoV-2刺突蛋白的支架设计：基于计算机模拟的视角
Ali Etemadi,Hamid Reza Moradi,Farideh Mohammadian et al.
Ali Etemadi et al.
Introduction: The COVID-19 pandemic is now affecting all people around the world and getting worse. New antiviral medications are desperately needed other than the few approved medications that have shown no promising eff...