Metabolic signals in sleep regulation: the role of brown adipose tissue [0.03%]
代谢信号在睡眠调节中的作用：棕色脂肪组织的作用
Éva Szentirmai,Levente Kapás
Éva Szentirmai
The regulation of sleep, while primarily attributed to the interplay between circadian and homeostatic processes, is significantly influenced by a multitude of additional factors that profoundly impact sleep quantity and quality. These fact...
Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection [0.03%]
感染的先天免疫机制：我们所了解的情况以及潜在的保守机制在感染期间影响睡眠
Mark R Zielinski,Sean D Carey,John A Craig
Mark R Zielinski
Evidence indicates relationships between sleep and the innate immune system during homeostatic sleep and sleep responses after infection. The innate immune system and sleep-like states are highly conserved between simple species and more co...
Vivek C Pandrangi,Jeremiah A Alt
Vivek C Pandrangi
Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is associated with significant quality of life (QOL) impairment, including sleep dysfunction. There are multiple factors that have been independently associated with poor s...
Sleep and immune health: How dogs, goats and 'factor S' shaped a field [0.03%]
睡眠与免疫健康：狗、山羊和“因子S”如何塑造了一个领域
Mark R Opp,Luca Imeri
Mark R Opp
Chronic insufficient sleep kills! Although this statement has high 'face validity', it is only recently that empirical evidence existed to support it. There are now sufficient data for numerous meta-analyses and systematic reviews to demons...
Modulation of adult hippocampal neurogenesis by interleukin 1 signaling [0.03%]
白细胞介素1信号对成人海马神经发生的作用
Maria I Smirnova,Ning Quan
Maria I Smirnova
Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders. The actions of the inflammatory cytokine inte...
Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury [0.03%]
小胶质细胞耗竭和再增殖在创伤性脑损伤小鼠模型中不同地调节睡眠和炎症反应
Katherine R Giordano,Tabitha R F Green,Mark R Opp et al.
Katherine R Giordano et al.
Traumatic brain injury (TBI) causes persistent sleep disturbances, leading to long-term neurological consequences and reduced quality of life. We hypothesized that microglial depletion via PLX5622 (PLX), a colony-stimulating factor 1 recept...
Effect of chronic sleep restriction on ethanol preference and cortical structural plasticity [0.03%]
慢性睡眠限制对酒精偏好及皮层结构可塑性的影响
Fernando Bravo-González,Mario Eduardo Acosta-Hernández,Hiram Tendilla-Beltrán et al.
Fernando Bravo-González et al.
Sleep loss is associated with a potential risk of using drugs such as cocaine, methamphetamines, and alcohol. Recently, our group showed that chronic sleep restriction (CSR) for 7 days/4 h induces a significant increase in ethanol intake an...
Synergies from a distance: Inspirations from the struggles of Dr James M Krueger [0.03%]
远距离的协同作用：向詹姆斯·克鲁格博士学习启示
William A Banks
William A Banks
In this article for Dr Krueger's Festschrift, I trace how his early career influenced many aspects in the fields of sleep, neuroimmunology, and the microbiome. Mostly, however, I trace how his career and interests intertwined with those of ...
Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation [0.03%]
MeCP2的丢失导致睡眠缺陷，这种缺陷随时间变化而改变，并且会因睡眠剥夺而恶化
Abrar Al Maghribi,Caitlin Ottaway,Michael Rempe et al.
Abrar Al Maghribi et al.
Rett syndrome (RTT) is a severe, progressive neurodevelopmental disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MECP2). Sleep problems are frequently reported in Rett Syndrome, but the exact nature r...
Neurobiology of the circadian clock and its role in cardiovascular disease: Mechanisms, biomarkers, and chronotherapy [0.03%]
生物钟的神经生物学及其在心血管疾病中的作用：机制、生物标志物和时间疗法
Abhimanyu Thakur,Raj Kishore
Abhimanyu Thakur
Cardiovascular diseases are paramount cause of morbidity in aging population and aging disrupts normal circadian rhythm cycle. Circadian rhythms, regulated by the suprachiasmatic nucleus in the brain, profoundly influence cardiovascular hea...