Effects of DNA methylation inhibitors on light-induced circadian clock plasticity [0.03%]
DNA甲基化抑制剂对光诱导的生物钟可塑性的影响
Suil Kim,Douglas G McMahon
Suil Kim
The suprachiasmatic nucleus (SCN) of the hypothalamus is a principal light-responsive circadian clock that adjusts circadian rhythms in mammalian physiology and behavior to changes in external light signals. Although mechanisms underlying h...
Sleep regularity and duration are associated with depression severity in a nationally representative United States sample [0.03%]
美国全国具代表性的样本中睡眠规律性和时长与抑郁严重程度相关
Katherine A Maki,Li Yang,Nicole Farmer et al.
Katherine A Maki et al.
Background: Sleep hygiene is integral to health, and sleep regularity may be associated with mental health outcomes in addition to duration. Although sleep and depression relationships are well-studied, the relative impac...
Local versus global sleep organization and the quest to determine sleep function [0.03%]
局部与整体的睡眠结构和探寻睡眠功能的作用任务
Hans P A Van Dongen
Hans P A Van Dongen
The research of JM Krueger and colleagues, focusing on sleep organization as a means to elucidate sleep function, led to critical insights as to why we sleep. Krueger posited that, fundamentally, sleep occurs locally at the level of neurona...
Mark R Opp,Rachel K Rowe,Hans P A Van Dongen
Mark R Opp
Metabolic signals in sleep regulation: the role of brown adipose tissue [0.03%]
代谢信号在睡眠调节中的作用：棕色脂肪组织的作用
Éva Szentirmai,Levente Kapás
Éva Szentirmai
The regulation of sleep, while primarily attributed to the interplay between circadian and homeostatic processes, is significantly influenced by a multitude of additional factors that profoundly impact sleep quantity and quality. These fact...
Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection [0.03%]
感染的先天免疫机制：我们所了解的情况以及潜在的保守机制在感染期间影响睡眠
Mark R Zielinski,Sean D Carey,John A Craig
Mark R Zielinski
Evidence indicates relationships between sleep and the innate immune system during homeostatic sleep and sleep responses after infection. The innate immune system and sleep-like states are highly conserved between simple species and more co...
Vivek C Pandrangi,Jeremiah A Alt
Vivek C Pandrangi
Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is associated with significant quality of life (QOL) impairment, including sleep dysfunction. There are multiple factors that have been independently associated with poor s...
Sleep and immune health: How dogs, goats and 'factor S' shaped a field [0.03%]
睡眠与免疫健康：狗、山羊和“因子S”如何塑造了一个领域
Mark R Opp,Luca Imeri
Mark R Opp
Chronic insufficient sleep kills! Although this statement has high 'face validity', it is only recently that empirical evidence existed to support it. There are now sufficient data for numerous meta-analyses and systematic reviews to demons...
Modulation of adult hippocampal neurogenesis by interleukin 1 signaling [0.03%]
白细胞介素1信号对成人海马神经发生的作用
Maria I Smirnova,Ning Quan
Maria I Smirnova
Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders. The actions of the inflammatory cytokine inte...
Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury [0.03%]
小胶质细胞耗竭和再增殖在创伤性脑损伤小鼠模型中不同地调节睡眠和炎症反应
Katherine R Giordano,Tabitha R F Green,Mark R Opp et al.
Katherine R Giordano et al.
Traumatic brain injury (TBI) causes persistent sleep disturbances, leading to long-term neurological consequences and reduced quality of life. We hypothesized that microglial depletion via PLX5622 (PLX), a colony-stimulating factor 1 recept...