Yu-Chien Hung,Mehran Akhtar,Nithish Sattoju et al.
Yu-Chien Hung et al.
The daily sleep-wake cycle is a conserved behaviour defined by locomotion quiescence and enhanced responsive threshold to sensory stimuli. Both the circadian clock and sleep-homeostasis determine the daily sleep profile. Environmental light...
Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness [0.03%]
阿尔茨海默病作为系统水平的节律障碍：胶质细胞免疫代谢、脑清除和治疗反应性的昼夜节律失调
Duc-Hiep Bach,Thanh Liem Nguyen
Duc-Hiep Bach
Alzheimer's disease (AD) is traditionally conceptualized as a disorder of protein aggregation and neurodegeneration, yet growing evidence indicates that fundamental temporal organization of brain physiology is also disrupted. In the healthy...
Michael C Tackenberg,Maria Luísa Jabbur,Vincent M Cassone et al.
Michael C Tackenberg et al.
A circadian clock enables an organism to occupy a particular temporal niche, and the evolutionary pressures associated with that temporal niche in turn shape the organization of the circadian network in which the clock is embedded. Although...
Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network [0.03%]
探究视交叉上核（SCN）起搏器网络多种神经元成分的功能
Mariko Izumo,Kimberly H Cox,Joseph S Takahashi
Mariko Izumo
The suprachiasmatic nucleus (SCN), a central clock in the hypothalamus of mammals, consists of heterogeneous populations of neurons. The SCN expresses various neurotransmitters/neuropeptides and hundreds of other genes as detected by cell c...
Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus [0.03%]
衰老小鼠睡眠中断及RNA测序分析下丘脑与年龄相关性睡眠片段化有关的因素
Kazuyuki Okamura,Rie Yanagisawa,Miyuki Sato et al.
Kazuyuki Okamura et al.
Aging is a risk factor for various disorders, and age-dependent changes in sleep parameters are involved in the pathogenesis of many diseases. Senescence-accelerated mice-prone 8 (SAMP8) have a short lifespan and show a disrupted circadian ...
Sleep stage classification from ECG using machine learning: Evaluating the impact of signal duration [0.03%]
基于机器学习的睡眠分期算法及心电图信号时长对其影响研究
Mohammadreza Iravani,Sadaf Moharreri
Mohammadreza Iravani
Sleep stage flagging is critical for diagnosing conditions like insomnia, sleep apnea, and narcolepsy. Traditional methods rely on time-intensive manual scoring by experts, limiting scalability and accessibility, especially in resource-limi...
Ali Kavehee,Fatemeh Kashaninasab,Mir Farhad Ghalehbandi et al.
Ali Kavehee et al.
Objective: Sleep disorders including insomnia, obstructive sleep apnea (OSA), narcolepsy and REM sleep behavior disorder (RBD), significantly impair cognition, emotional wellbeing and physical health. This review synthesi...
Cortical excitability is affected by light exposure - Distinct effects in adolescents and young adults [0.03%]
光照影响皮质兴奋性——青少年组和年轻成人组的效应不同
Roya Sharifpour,Fermin Balda,Ilenia Paparella et al.
Roya Sharifpour et al.
Light, particularly blue-wavelength light exerts a broad range of non-image forming (NIF) effects including the stimulation of cognition and alertness and the regulation of mood, sleep and circadian rhythms. However, its underlying brain me...
Identification of photoperiod as a regulator of dopamine-mediated behavior in female mice [0.03%]
鉴定出光周期是女鼠多巴胺介导行为的调节因子
Beimnet B Kassaye,Alexis N Jameson,Katherine Moore et al.
Beimnet B Kassaye et al.
Photoperiod is the primary environmental cue that regulates changes in behavior across seasons. Previously, we have shown that photoperiod has sex-specific effects on synaptic dopamine dynamics in the nucleus accumbens (NAc). Further, evide...
Chronotype in alpha-tACS: Preliminary evidence hints at sleep quality modulation of aftereffects in evening types in the morning [0.03%]
清晨针对晚上型人调节睡眠质量的α-tACS初步证据表明有后效现象
Peppi Schulz,Heiko I Stecher,Christoph S Herrmann
Peppi Schulz
Transcranial alternating current stimulation (tACS) is a promising tool for research on oscillatory brain activity, yet both behavioral and electrophysiological outcome measures show high variability across studies. One source for this vari...