Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice [0.03%]
小鼠急性睡眠干扰和高脂饮食引起的下丘脑炎症与葡萄糖耐量无相关性
Jacqueline M Ho,Nicole H Ducich,Nhat-Quynh K Nguyen et al.
Jacqueline M Ho et al.
Chronic insufficient sleep is a major societal problem and is associated with increased risk of metabolic disease. Hypothalamic inflammation contributes to hyperphagia and weight gain in diet-induced obesity, but insufficient sleep-induced ...
Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease [0.03%]
睡眠改善可以逆转阿尔茨海默病果蝇模型中的记忆缺陷及其潜在发病机制
Stephane Dissel,Markus Klose,Jeff Donlea et al.
Stephane Dissel et al.
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. ...
Aleksandar Videnovic,Diego Golombek
Aleksandar Videnovic
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive d...
Jerrah Holth,Tirth Patel,David M Holtzman
Jerrah Holth
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relatio...
Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection [0.03%]
小鼠白介素37的表达改变了炎症介质和流感病毒感染诱发的睡眠反应
Christopher J Davis,Mark R Zielinski,Danielle Dunbrasky et al.
Christopher J Davis et al.
Multiple interactions between the immune system and sleep are known, including the effects of microbial challenge on sleep or the effects of sleep loss on facets of the immune response. Cytokines regulate, in part, sleep and immune response...
Bedtime and evening light exposure influence circadian timing in preschool-age children: A field study [0.03%]
就寝时间和晚间光照暴露会影响学龄前儿童的昼夜节律：实地研究
Lameese D Akacem,Kenneth P Wright Jr,Monique K LeBourgeois
Lameese D Akacem
Light exposure and sleep timing are two factors that influence inter-individual variability in the timing of the human circadian clock. The aim of this study was to quantify the degree to which evening light exposure predicts variance in ci...
EEG slow waves in traumatic brain injury: Convergent findings in mouse and man [0.03%]
创伤性脑损伤的EEG慢波：小鼠和人类研究结果的一致性发现
Mo Modarres,Nicholas N Kuzma,Tracy Kretzmer et al.
Mo Modarres et al.
Objective: Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to ...
Sleep Physiology in Toddlers: Effects of Missing a Nap on Subsequent Night Sleep [0.03%]
午睡对幼儿后续夜间睡眠的影响
Jonathan M Lassonde,Thomas Rusterholz,Salome Kurth et al.
Jonathan M Lassonde et al.
The shift from a biphasic to a monophasic sleep schedule is a fundamental milestone in early childhood. This transition, however, may result in periods of acute sleep loss as children may nap on some but not all days. Although data indicati...