Víctor M Navarro
Víctor M Navarro
The tachykinin family of peptides has emerged as a critical component of the central control of the reproductive axis. Mounting evidence suggests that neurokinin B (NKB) plays an essential role in sexual maturation and fertility by directly...
Abnormal GnRH Pulsatility in Polycystic Ovary Syndrome: Recent Insights [0.03%]
多囊卵巢综合征中促性腺激素释放激素脉冲异常的新见解
Christopher R McCartney,Rebecca E Campbell
Christopher R McCartney
Although the fundamental symptoms of polycystic ovary syndrome (PCOS) relate most directly to ovarian dysfunction, central neuroendocrine systems play a prominent role in its pathophysiology. Gonadotropin-releasing hormone (GnRH) pulse gene...
Emilia Modolo Pinto,Katja Kiseljak-Vassiliades,Constanze Hantel
Emilia Modolo Pinto
Adrenocortical carcinoma (ACC) is an uncommon and heterogeneous disease and may present differently in children and adults. Management of ACC is dependent on disease stage and complete surgical resection is the only potentially curative tre...
Psychosexual effects resulting from delayed, incomplete, or absent puberty [0.03%]
延迟、不全或缺失青春期的心理性影响
Andrew A Dwyer
Andrew A Dwyer
Puberty is a remarkable period of postnatal development culminating in reproductive capacity. Biological changes of puberty are accompanied by social and emotional changes including psychosexual development. Developmental changes of adolesc...
The contribution of rare genetic variants to the pathogenesis of polycystic ovary syndrome [0.03%]
罕见遗传变异在多囊卵巢综合征发病机制中的作用
Matthew Dapas,Andrea Dunaif
Matthew Dapas
Polycystic ovary syndrome (PCOS) is a highly heritable disorder, but only a small proportion of the heritability can be accounted for by common genetic risk variants identified to date. It is possible that variants with lower allele frequen...
Endocrine-Metabolic Dysfunction in Polycystic Ovary Syndrome: an Evolutionary Perspective [0.03%]
从进化角度审视多囊卵巢综合征的内分泌代谢紊乱
Daniel A Dumesic,David H Abbott,Smriti Sanchita et al.
Daniel A Dumesic et al.
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology, with metabolic dysfunction from insulin resistance and abdominal fat accumulation worsened by obesity. As ancestral ...
New strategies for applying targeted therapies to adrenocortical carcinoma [0.03%]
面向肾上腺皮质癌应用靶向治疗的新策略
Dipika R Mohan,Antonio Marcondes Lerario,Isabella Finco et al.
Dipika R Mohan et al.
Adrenocortical carcinoma (ACC) is a rare, aggressive, and frequently deadly cancer. Up to 75% of all patients will eventually develop metastatic disease, and our current medical therapies for ACC provide limited - if any - survival benefit....
Isabella Finco,Dipika R Mohan,Gary D Hammer et al.
Isabella Finco et al.
The adrenal cortex is an endocrine organ comprised of three histological zones, the outermost zona glomerulosa, the intermediate zona fasciculata, and the innermost zona reticularis. High plasticity of the adrenal gland is supported by pool...
Resistance Mechanisms to Taxanes and PARP Inhibitors in Advanced Prostate Cancer [0.03%]
转移性前列腺癌耐药机制的研究进展：紫杉烷类和PARP抑制剂
Alan P Lombard,Allen C Gao
Alan P Lombard
The clinical landscape concerning advanced prostate cancer is rapidly changing and reaching beyond androgen deprivation therapy and androgen receptor targeted therapies. Taxane chemotherapy is a critical tool in the management of advanced p...
Testosterone Replacement in Men with Age-Related Low Testosterone: What Did We Learn From The Testosterone Trials? [0.03%]
男性年龄相关性睾酮水平低下 testosterone 替代治疗的获益与风险——睾酮临床研究结果解读
Alvin M Matsumoto
Alvin M Matsumoto
The T Trials were a coordinated set of seven double-blind, placebo-controlled trials to assess efficacy and safety of testosterone versus placebo gel treatment for one year in 788 older men 65 years or older with hypogonadism who had self-r...