Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis [0.03%]
骨和骨髓稳态中的脂肪素表达骨骼干细胞/前体细胞
Biagio Palmisano,Alessandro Corsi,Mara Riminucci
Biagio Palmisano
The bone marrow stroma supports hematopoiesis while replenishing osteoblasts and adipocytes. These functions rely on different stromal cell populations identified by lineage tracing, phenotypic markers and single-cell transcriptomic analysi...
Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers [0.03%]
针对甲状腺癌血管生成和免疫微环境之间通讯的治疗措施
Alessandro Prete,Carmelo Nucera
Alessandro Prete
Thyroid cancer treatment has recently been revolutionized by the introduction of specific targeted therapies (e.g. BRAFV600E or highly selective RET inhibitors), anti-angiogenic agents (e.g. tyrosine kinase inhibitors (TKIs)) and immune che...
Attenuation of adipose tissue inflammation by pro-resolving lipid mediators [0.03%]
前列腺素介质缓解脂肪组织炎症反应
Madison Clark,Bianca E Suur,Matúš Soták et al.
Madison Clark et al.
Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of i...
Paraventricular nucleus-Medullary interactions: How they help enable endocrine responses to metabolic stress [0.03%]
室管膜下核-脑干相互作用：它们如何帮助内分泌应对代谢压力反应
Alan G Watts
Alan G Watts
The paraventricular hypothalamic nucleus (PVH) organizes neuroendocrine and autonomic responses to rapidly and slowly developing metabolic stressors that limit their impact on energy balance. The PVH together with the lateral hypothalamic a...
How preclinical models of menopause can inform clinical care: A focus on midlife and reciprocal communication between clinical and preclinical science [0.03%]
绝经前临床模型如何改善临床护理：注重中年和临床与前临床科学的相互交流
Heather A Bimonte-Nelson,Victoria E Bernaud
Heather A Bimonte-Nelson
Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that infl...
Heather Wachtel,Katherine L Nathanson
Heather Wachtel
Pheochromocytomas and paragangliomas (PPGL) are neuroendocrine tumors which secrete catecholamines, causing cardiovascular compromise. While isolated tumors and locoregional disease can be treated surgically, treatment options for metastati...
Metabolic small talk during exercise: The role of metabokines and lipokines in interorgan signalling [0.03%]
运动时的代谢小对话：代谢激素和脂质激素在器官间信号传递中的作用
Shaimaa A Gad,Hannah Smith,Lee D Roberts
Shaimaa A Gad
Metabolites in exercise have traditionally been viewed as a fuel source, waste product, or anabolic components required for exercise-induced biosynthetic processes. However, it is now recognised that metabolites and lipids may act as mediat...
Ruth Andrew,Roland H Stimson
Ruth Andrew
Hormones regulate metabolic homeostasis through interlinked dynamic networks of proteins and small molecular weight metabolites, and state-of-the-art chemical technologies have been developed to decipher these complex pathways. Stable-isoto...
Fiona L Roberts,Vicky E MacRae
Fiona L Roberts
Recent advancements in the bone biology field have identified a novel bone-metabolism axis. In this review, we highlight several novel studies that further our knowledge of new endocrine functions of bone; explore remaining unanswered quest...
Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia [0.03%]
近年来低血糖防御反应下丘脑调控研究的进展
Emily O Staricoff,Mark L Evans
Emily O Staricoff
Maintenance of normal blood glucose is important for survival. In particular, brain function is dependent on circulating glucose. In health, a series of powerful counterregulatory defences operate to prevent/limit hypoglycaemia. These defen...